CD4 T cells require ICOS-mediated PI3K signaling to increase T-Bet expression in the setting of anti-CTLA-4 therapy

Cancer immunology research

Volumn 2, Issue 2, 2014, Pages 167-176

  Chen, Hong ^a   Fu, Tihui ^a   Suh, Woong Kyung ^a   Tsavachidou, Dimitra ^a   Wen, Sijin ^a   Gao, Jianjun ^a   Ng Tang, Derek ^a   He, Qiuming ^a   Sun, Jingjing ^a   Sharma, Padmanee ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; ICOSLG PROTEIN, HUMAN; INDUCIBLE T CELL COSTIMULATOR LIGAND; IPILIMUMAB; MONOCLONAL ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE; SMALL INTERFERING RNA; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR TBX21;

ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; CANCER TRANSPLANTATION; CARCINOMA, TRANSITIONAL CELL; CD4+ T LYMPHOCYTE; CLINICAL TRIAL; DRUG EFFECTS; GENETICS; HUMAN; IMMUNOLOGY; IMMUNOTHERAPY; KNOCKOUT MOUSE; MELANOMA; METABOLISM; PATHOLOGY; PROCEDURES; SIGNAL TRANSDUCTION; TH1 CELL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CARCINOMA, TRANSITIONAL CELL; CD4-POSITIVE T-LYMPHOCYTES; CTLA-4 ANTIGEN; CYTOKINES; HUMANS; IMMUNOTHERAPY; INDUCIBLE T-CELL CO-STIMULATOR LIGAND; MELANOMA; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASM TRANSPLANTATION; PHOSPHATIDYLINOSITOL 3-KINASES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; T-BOX DOMAIN PROTEINS; TH1 CELLS;

EID: 84996490571     PISSN: None     EISSN: 23266074     Source Type: Journal    
DOI: 10.1158/2326-6066.CIR-13-0155     Document Type: Article

References (0)