Pathways for oxygen regulation and homeostasis: The 2016 albert lasker basic medical research award

JAMA - Journal of the American Medical Association

Volumn 316, Issue 12, 2016, Pages 1252-1253

  Kaelin, William G ^a   Ratcliffe, Peter J ^b   Semenza, Gregg L ^c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; DIOXYGENASE; ERYTHROPOIETIN; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; OXYGEN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEASOME; UBIQUITIN; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN;

CAENORHABDITIS ELEGANS; CATALYSIS; CELL HYPOXIA; CELL LEVEL; COMPLEX FORMATION; DECARBOXYLATION; ENERGY RESOURCE; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HEPATOMA CELL; HOMEOSTASIS; HUMAN; HYDROXYLATION; INTRACELLULAR SIGNALING; NONHUMAN; OXYGEN AFFINITY; OXYGEN CONSUMPTION; OXYGEN SENSING; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROCESSING; REGULATORY MECHANISM; REPORTER GENE; SHORT SURVEY; ANIMAL; AWARDS AND PRIZES; CELL FUNCTION; METABOLISM;

ANIMALS; AWARDS AND PRIZES; CELL PHYSIOLOGICAL PHENOMENA; HOMEOSTASIS; HUMANS; OXYGEN;

EID: 84995811832     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2016.12386     Document Type: Short Survey

References (6)

1. Iliopoulos O, Levy AP, Jiang C, et al. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc Natl Acad Sci U S A. 1996;93(20):10595-10599.
2. IvanM, Kondo K, Yang H, et al. HIFa targeted for VHL-mediated destruction by proline hydroxylation. Science. 2001;292(5516):464-468.
3. Semenza GL,Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol. 1992;12(12):5447-5454.
4. Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A. 1995;92(12):5510-5514.
5. Maxwell PH, Pugh CW, Ratcliffe PJ. Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen sensing mechanism. Proc Natl Acad Sci U S A. 1993;90(6):2423-2427.
6. Epstein ACR, Gleadle JM, McNeill LA, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. 2001;107(1):43-54.