A randomized trial comparing the effect of nicotine versus placebo electronic cigarettes on smoking reduction among young adult smokers

Nicotine and Tobacco Research

Volumn 18, Issue 10, 2016, Pages 1937-1943

  Tseng, Tuo Yen ^a   Ostroff, Jamie S ^b   Campo, Alena ^a   Gerard, Meghan ^a   Kirchner, Thomas ^a,c   Rotrosen, John ^a   Shelley, Donna ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINE; PLACEBO; NICOTINE GUM;

ABNORMAL DREAMING; ADULT; ARTICLE; CONTROLLED STUDY; COUGHING; DOUBLE BLIND PROCEDURE; ELECTRONIC CIGARETTE; FATIGUE; FEMALE; HEADACHE; HUMAN; INSOMNIA; MALE; PILOT STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SELF CONCEPT; SELF REPORT; SMOKING CESSATION; THROAT IRRITATION; TOBACCO DEPENDENCE; UNITED STATES; YOUNG ADULT; PREVENTION AND CONTROL; PROCEDURES; SMOKING; TREATMENT OUTCOME;

ADULT; DOUBLE-BLIND METHOD; ELECTRONIC CIGARETTES; FEMALE; HUMANS; MALE; NICOTINE; SMOKING; SMOKING CESSATION; TOBACCO USE CESSATION PRODUCTS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84995693676     PISSN: 14622203     EISSN: 1469994X     Source Type: Journal    
DOI: 10.1093/ntr/ntw017     Document Type: Article

References (44)

1. McMillen RC, Gottlieb MA, Shaefer RMW, Winickoff J, Klein JD. Trends in electronic cigarette use among U.S. adults: use is increasing in both smokers and nonsmokers. Nicotine Tob Res. 2014;17(10):1195-1202. doi:10.1093/ntr/ntu213.
2. Adkison SE, O'Connor RJ, Bansal-Travers M, et al. Electronic Nicotine Delivery Systems International tobacco control four-country survey. Am J Prev Med. 2013;44(3):207-215. doi:10.1016/j.amepre.2012.10.018.
3. Etter JF, Bullen C. Electronic cigarette: users profile, utilization, satisfaction and perceived efficacy. Addiction. 2011;106(11):2017-2028. doi:10.1111/j.1360-0443.2011.03505.x.
4. Fiore MC, Jaén CR, Baker TB, et al. Treating Tobacco Use and Dependence: 2008 Update. Clinical Practice Guideline. Rockville, MD: U.S. DIANE Publishing; 2008.
5. Dawkins L, Turner J, Hasna S, Soar K. The electronic cigarette-Effects on desire to smoke, withdrawal symptoms and cognition. Addict Behav. 2012;37(8):970-973. doi:10.1016/j.addbeh.2012.03.004.
6. Dawkins L, Turner J, Crowe E. Nicotine derived from the electronic cigarette improves time-based prospective memory in abstinent smokers. 2013;227(3):377-384. doi:10.1007/s00213-013-2983-2.
7. Dawkins L, Corcoran O. Acute electronic cigarette use: nicotine delivery and subjective effects in regular users. Psychopharmacology. 2014;231(2):401-407. doi:10.1007/s00213-013-3249-8.
8. Vansickel AR, Cobb CO, Weaver MF, Eissenberg TE. A clinical laboratory model for evaluating the acute effects of electronic "cigarettes": nicotine delivery profile and cardiovascular and subjective effects. Cancer Epidemiol Biomarkers Prevent. 2010;19(8):1945-1953. doi:10.1158/1055-9965. EPI-10-0288.
9. Vansickel AR, Weaver MF, Eissenberg T. Clinical laboratory assessment of the abuse liability of an electronic cigarette. Addiction. 2012;107(8):1493-1500. doi:10.1111/j.1360-0443.2012.03791.x.
10. McRobbie H, Bullen C, Hartmann-Boyce J, Hajek P. Electronic cigarettes for smoking cessation and reduction. Cochrane Database Syst Rev. 2014;12. doi:10.1002/14651858.CD010216.pub2.
11. Bullen C, Howe C, Laugesen M, et al. Electronic cigarettes for smoking cessation: a randomised controlled trial. Lancet. 2013;382(9905):1629-1637. doi:10.1016/S0140-6736(13)61842-5.
12. Caponnetto P, Campagna D, Cibella F, et al. EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as tobacco cigarettes substitute: a prospective 12-month randomized control design study. PloS One. 2103;8(6):e66317. doi:10.1371/journal.pone.0066317.
13. Stead LF, Lancaster T. Interventions to reduce harm from continued tobacco use. Cochrane Database Syst Rev. 2007;3. doi:10.1002/14651858. CD005231.pub2.
14. Nides MA, Leischow SJ, Bhatter M, Simmons M. Nicotine blood levels and short-term smoking reduction with an electronic nicotine delivery system. Am J Health Behav. 2014;38(2):265-274. doi:10.5993/AJHB.38.2.12.
15. Adriaens K, Van Gucht D, Declerck P, Baeyens F. Effectiveness of the electronic cigarette: an eight-week Flemish study with six-month follow-up on smoking reduction, craving and experienced benefits and complaints. Int J Environ Res Public Health. 2014;11(11):11220-11248. doi:10.3390/ijerph111111220.
16. King BA, Patel R, Nguyen KH, Dube SR. Trends in Awareness and Use of Electronic Cigarettes Among US Adults, 2010-2013. Nicotine Tob Res. 2015;17(2):219-227. doi:10.1093/ntr/ntu191.
17. Pearson JL, Richardson A, Niaura RS, Vallone DM, Abrams DB. E-cigarette awareness, use, and harm perceptions in US adults. Am J Public Health. 2012;102(9):1758-1766. doi:10.2105/AJPH.2011.300526.
18. Joseph AM, Hecht SS, Murphy SE, et al. Smoking reduction fails to improve clinical and biological markers of cardiac disease: a randomized controlled trial. Nicotine Tob Res. 2008;10(3):471-481. doi:10.1080/14622200801901948.
19. Glasgow RE, Gaglio B, Estabrooks PA, et al. Long-term results of a smoking reduction program. Medical Care. 2009;47(1):115-120. doi:10.1097/MLR.0b013e31817e18d1.
20. Bush K, Kihlavan DR, McConell MB, Fihn SD, Bradley KA. The AUDIT alcohol consumption questions (AUDIT-C): an effective brief screening test for problem drinking. Arch Int Med. 1998;158(16):1789-1795. doi:10.1001/archinte.158.16.1789.
21. Skinner HA. The drug abuse screening test. Addict Behav. 1982;7(4):363-371. doi:10.1016/0306-4603(82)90005-3.
22. Heatherton TF, Kozlowski LT, Frecker RC, Rickert W, Robinson J. Measuring the heaviness of smoking: using self-reported time to the first cigarette of the day and number of cigarettes smoked per day. Br J Addict. 1989;84(7):791-800. doi:10.1111/j.1360-0443.1989.tb03059.x.
23. Glover ED, Nilsson F, Westin A, et al. Developmental history of the Glover-Nilsson smoking behavioral questionnaire. Am J Health Behav. 2005;29(5):443-455. doi:10.5993/AJHB.29.5.7.
24. Biener L, Abrams DB. The Contemplation Ladder: validation of a measure of readiness to consider smoking cessation. Health Psychol. 1991;10(5):360-365. doi:10.1037/0278-6133.10.5.360.
25. Dawkins L. Why is it so hard to quit smoking? Psychologist. 2013;26(5):332-335. https://thepsychologist.bps.org.uk/volume-26/edition-5/why-it-so-hard-quit-smoking. Accessed March 25, 2015.
26. Fagerstrom KO, Heatherton TF, Kozlowski LT. Nicotine addiction and its assessment. Ear Nose Throat J. 1990;69(11):763-765. www.dartmouth. edu/~thlab/pubs/90_Fagerstrom_etal_ENTJ.pdf. Accessed March 25, 2015.
27. Rose JE. Nicotine and nonnicotine factors in cigarette addiction. Psychopharmacology. 2006;184(3-4):274-285. doi:10.1007/s00213-005-0250-x.
28. Shiffman S, Kirchner TR. Cigarette-by-cigarette satisfaction during ad libitum smoking. J Abnorm Psychol. 2009;118(2):348-359. doi:10.1037/a0015620.
29. Rose JE, Tashkin DP, Ertle A, Zinser MC, Lafer R. Sensory blockade of smoking satisfaction. Pharmacol Biochem Behav. 1985;23(2):289-293. doi:10.1016/0091-3057(85)90572-6.
30. Butschky MF, Bailey D, Henningfield JE, Pickworth WB. Smoking without nicotine delivery decreases withdrawal in 12-hour abstinent smokers. Pharmacol Biochem Behav. 1995;50(1):91-96. doi:10.1016/0091-3057(94)00269-O.
31. Rose JE, Salley A, Behm FM, Bates JE, Westman EC. Reinforcing effects of nicotine and non-nicotine components of cigarette smoke. Psychopharmacology. 2010;210(1):1-12. doi:10.1007/s00213-010-1810-2.
32. Wagener TL, Siegel M, Borrelli B. Electronic cigarettes: achieving a balanced perspective. Addiction. 2012;107(9):1545-1548. doi:10.1111/j.1360-0443.2012.03826.x.
33. Henningfield JE. The tobacco endgame: it's all about behavior. Prev Med. 2014;68:11-16. doi:10.1016/j.ypmed.2014.09.003.
34. Lindson-Hawley N, Aveyard P, Hughes JR. Reduction versus abrupt cessation in smokers who want to quit. Cochrane Database Syst Rev. 2012;11. doi:10.1002/14651858.CD008033.pub3.
35. Hughes JR, Carpenter MJ. Does smoking reduction increase future cessation and decrease disease risk? A qualitative review. Nicotine Tob Res. 2006;8(6):739-749. doi:10.1080/14622200600789726.
36. Benowitz NL, Goniewicz MJ. The regulatory challenge of electronic cigarettes. JAMA. 2013;310(7):685-686. doi:10.1001/jama.2013.109501.
37. Biener L, Hargraves JL. A longitudinal study of electronic cigarette use among a population-based sample of adult smokers: association with smoking cessation and motivation to quit. Nicotine Tob Res. 2015;17(2):127-133. doi:10.1093/ntr/ntu200.
38. Choi K, Forster J. Characteristics associated with awareness, perceptions, and use of electronic nicotine delivery systems among young US Midwestern adults. Am J Public Health. 2013;103(3):556-561. doi:10.2105/AJPH.2012.300947.
39. Ramo DE, Young-Wolff KC, Prochaska JJ. Prevalence and correlates of electronic-cigarette use in young adults: findings from three studies over five years. Addict Behav. 2015;41:142-147. doi:10.1016/j. addbeh.2014.10.019.
40. Fu SS, Sherman SE, Yano EM, van Ryn M, Lanto AB, Joseph AM. Ethnic disparities in the use of nicotine replacement therapy for smoking cessation in an equal access health care system. Am J Health Promot. 2005;20(2):108-116. doi:10.4278/0890-1171-20.2.108.
41. Brown CJ, Cheng JM. Electronic cigarettes: product characterisation and design considerations. Tob Control. 2014;23(suppl 2):ii4-10. doi:10.1136/tobaccocontrol-2013-051476.
42. Farsalinos KE, Romagna G, Tsiapras D, Kyrzopoulos S, Spyrou A, Voudris V. Impact of flavour variability on electronic cigarette use experience: an internet survey. Int J Environ Res Public Health. 2013;10(12):7272-7282. doi:10.3390/ijerph10127272.
43. Polosa R, Caponnetto P, Cibella F, Le-Houezec J. Quit and smoking reduction rates in vape shop consumers: a prospective 12-month survey. Int J Environ Res Public Health. 2015;12(4):3428-3438. doi:10.3390/ijerph120403428.
44. Brandon TH, Goniewicz ML, Hanna N, et al. Electronic nicotine delivery systems: a policy statement from the American Association for Cancer Research and the American Society of Clinical Oncology. Clin Cancer Res. 2015;21(3):514-525. doi:10.1158/1078-0432. CCR-14-2544.