Active case finding for carbapenemase-producing Enterobacteriaceae in a teaching hospital: prevalence and risk factors for colonization

Journal of Hospital Infection

Volumn 94, Issue 2, 2016, Pages 125-129

  Poole, K ^a   George, R ^b   Decraene, V ^a   Shankar, K ^a   Cawthorne, J ^b   Savage, N ^d   Welfare, W ^a,c   Dodgson, A ^a,b  

^a PUBLIC HEALTH ENGLAND   (United Kingdom)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Carbapenemase; Enterobacteriaceae; Multiple antibacterial drug resistance; Prevalence; Risk factors

Indexed keywords

ANTIBIOTIC AGENT; PROTON PUMP INHIBITOR; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE; CARBAPENEMASE;

ADOLESCENT; ADULT; AGE; AGED; ARTICLE; BACTERIAL COLONIZATION; CARBAPENEMASE PRODUCING ENTEROBACTERIACEAE; CASE CONTROL STUDY; CONTROLLED STUDY; DEMOGRAPHY; ETHNICITY; FEMALE; HOSPITAL ADMISSION; HUMAN; INFECTION RISK; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PREVALENCE; RISK ASSESSMENT; RISK FACTOR; TEACHING HOSPITAL; CROSS INFECTION; DRUG EFFECTS; DRUG UTILIZATION; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; ENZYMOLOGY; HETEROZYGOTE; ISOLATION AND PURIFICATION; MICROBIOLOGY; MIDDLE AGED; MULTIDRUG RESISTANCE; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; CARRIER STATE; CASE-CONTROL STUDIES; CROSS INFECTION; DRUG RESISTANCE, MULTIPLE, BACTERIAL; DRUG UTILIZATION; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; FEMALE; HOSPITALS, TEACHING; HUMANS; MALE; MIDDLE AGED; PREVALENCE; PROTON PUMP INHIBITORS; RISK FACTORS; YOUNG ADULT;

EID: 84995687694     PISSN: 01956701     EISSN: 15322939     Source Type: Journal    
DOI: 10.1016/j.jhin.2016.06.019     Document Type: Article

References (12)

1. 1 Public Health England, Acute trust tool kit for the early detection, management and control of carbapenemase-producing enterobacteriaceae. 2013, PHE, London Available at: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/329227/Acute_trust_toolkit_for_the_early_detection.pdf [last accessed January 2016].
2. 2 Public Health England, Laboratory detection and reporting of bacteria with carbapenem-hydrolysing ß-lactamases (carbapenemases)., 2014, PHE, London Available at: http://webarchive.nationalarchives.gov.uk/20140629102627/http://hpa.org.uk/webw/HPAweb&HPAwebStandard/HPAweb_C/1317138518829 [last accessed December 2014].
3. 3 European Centre for Disease Prevention and Control, Systematic review of the effectiveness of infection control measures to prevent the transmission of carbapenemase-producing Enterobacteriaceae through cross-border transfer of patients. 2014, ECDC, Stockholm Available at: http://ecdc.europa.eu/en/publications/publications/cpe-systematic-review-effectiveness-infection-control-measures-to-prevent-transmission-2014.pdf [last accessed January 2015].
4. 4 Wiener-Well, Y., Rudensky, B., Yinnon, A.M., et al. Carriage rate of carbapenem-resistant Klebsiella pneumoniae in hospitalised patients during a national outbreak. J Hosp Infect 74 (2010), 344–349.
5. 5 Lin, M.Y., Lyles-Banks, R.D., Lolans, K., et al., Centers for Disease Control and Prevention Epicenters Program. The importance of long-term acute care hospitals in the regional epidemiology of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae. Clin Infect Dis 57 (2013), 1246–1252.
6. 6 Bhargava, A., Hayakawa, K., Silverman, E., et al. Risk factors for colonization due to carbapenem-resistant Enterobacteriaceae among patients exposed to long-term acute care and acute care facilities. Infect Control Hosp Epidemiol 35 (2014), 398–405.
7. 7 Kanerva, M., Skogberg, K., Ryynänen, K., et al. Coincidental detection of the first outbreak of carbapenemase-producing Klebsiella pneumoniae colonisation in a primary care hospital, Finland, 2013. Eurosurveillance, 20, 2015, 26 Available at: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=21172 [last accessed July 2015].
8. 8 Public Health England, Acute trust toolkit for the early detection, management and control of carbapenemase-producing Enterobacteriaceae: frequently asked questions for health professionals. 2014, PHE, London Available at: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/329229/CPE_Acute_Trust_Toolkit_FAQs_for_Health_Professionals.pdf [last accessed December 2014].
9. 9 Gijón, D., Curiao, T., Baquero, F., Coque, T.M., Cantón, R., Fecal carriage of carbapenemase-producing Enterobacteriaceae: a hidden reservoir in hospitalized and nonhospitalized patients. J Clin Microbiol 50 (2012), 1558–1563.
10. 10 Johnson, J.K., Wilson, L.E., Zhao, L., Richards, K., Thom, K.A., Harris, A.D., Maryland Multidrug-Resistant Organism Prevention Collaborative. Point prevalence of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae in Maryland. Infect Control Hosp Epidemiol 35 (2014), 443–445.
11. 11 Vidal-Navarro, L., Pfeiffer, C., Bouziges, N., Sotto, A., Lavigne, J.P., Faecal carriage of multidrug-resistant Gram-negative bacilli during a non-outbreak situation in a French university hospital. J Antimicrob Chemother 65 (2010), 2455–2458.
12. 12 Adler, A., Hussein, O., Ben-David, D., et al., Post-Acute-Care Hospital Carbapenem-Resistant Enterobacteriaceae Working Group. Persistence of Klebsiella pneumoniae ST258 as the predominant clone of carbapenemase-producing Enterobacteriaceae in post-acute-care hospitals in Israel, 2008–13. J Antimicrob Chemother 70 (2015), 89–92.