Hyperthermia, the tumor microenvironment and immunity

Tumor Ablation: Effects on Systemic and Local Anti-Tumor Immunity and on Other Tumor-Microenvironment Interactions

Volumn , Issue , 2013, Pages 29-37

  Calderwood, Stuart K ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Cell; Death; Dendritic cell; Fever; Heat shock protein; Hyperthermia; Immunity; Molecular chaperone; Necrosis; Regression; Thermal ablation; Tlymphocytes; Tumor; Tumor microenvironment

Indexed keywords

EID: 84995533512     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-94-007-4694-7_2     Document Type: Chapter

References (57)

1. Hahn GM (1982) Hyperthermia and cancer. Plenum, New York
2. Harden LM, Du Plessis I, Poole S, Laburn HP (2008) Interleukin (IL)-6 and IL-1 beta act synergistically within the brain to induce sickness behavior and fever in rats. Brain Behav Immun 22:838-849
3. Nilsberth C et al (2009) The role of interleukin-6 in lipopolysaccharide-induced fever by mechanisms independent of prostaglandin E2. Endocrinology 150:1850-1860
4. Dickson JA, Calderwood SK (1983) Thermosensitivity of neoplastic tissues. G.K. Hall, Boston
5. Kraybill WG et al (2002) A phase I study of fever-range whole body hyperthermia (FR-WBH) in patients with advanced solid tumours: correlation with mouse models. Int J Hyperthermia 18:253-266
6. Webb H, Lubner MG, Hinshaw JL (2011) Thermal ablation. Semin Roentgenol 46:133-141
7. Van Der Zee J et al (2000) Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial. Dutch deep hyperthermia group. Lancet 355:1119-1125
8. Issels RD (2008) Hyperthermia adds to chemotherapy. Eur J Cancer 44:2546-2554
9. Folkman J (2006) Angiogenesis. Annu Rev Med 57:1-18
10. Gullino PM (1966) The internal milieu of tumors. Prog Exp Tumor Res 8:1-25
11. Dang CV (2010) Rethinking the Warburg effect with Myc micromanaging glutamine metabolism. Cancer Res 70:859-862
12. Warburg O (1956) On the origin of cancer cells. Science 123:309-314
13. Pardoll D (2003) Does the immune system see tumors as foreign or self? Annu Rev Immunol 21:807-839
14. Engelhard VH, Bullock TN, Colella TA, Sheasley SL, Mullins DW (2002) Antigens derived from melanocyte differentiation proteins: self-tolerance, autoimmunity, and use for cancer immunotherapy. Immunol Rev 188:136-146
15. Srivastava PK, Old LJ (1988) Individually distinct transplantation antigens of chemically induced mouse tumors. Immunol Today 9:78-83
16. Murshid A, Gong J, Stevenson MA, Calderwood SK (2011) Heat shock proteins and cancer vaccines: developments in the past decade and chaperoning in the decade to come. Expert Rev Vaccines 10:1553-1568
17. Schatton T, Frank MH (2009) Antitumor immunity and cancer stem cells. Ann N Y Acad Sci 1176:154-169
18. Ostberg JR, Repasky EA (2000) Use of mild, whole body hyperthermia in cancer therapy. Immunol Invest 29:139-142
19. Peer AJ, Grimm MJ, Zynda ER, Repasky EA (2010) Diverse immune mechanisms may contribute to the survival benefit seen in cancer patients receiving hyperthermia. Immunol Res 46:137-154
20. Evans SS et al (2001) Fever-range hyperthermia dynamically regulates lymphocyte delivery to high endothelial venules. Blood 97:2727-2733
21. Ostberg JR, Dayanc BE, Yuan M, Oflazoglu E, Repasky EA (2007) Enhancement of natural killer (NK) cell cytotoxicity by fever-range thermal stress is dependent on NKG2D function and is associated with plasma membrane NKG2D clustering and increased expression of MICA on target cells. J Leukoc Biol 82:1322-1331
22. Ostberg JR, Taylor SL, Baumann H, Repasky EA (2000) Regulatory effects of fever-range whole-body hyperthermia on the LPS-induced acute inflammatory response. J Leukoc Biol 68:815-820
23. Xu Y et al (2007) Fever-range whole body hyperthermia increases the number of perfused tumor blood vessels and therapeutic efficacy of liposomally encapsulated doxorubicin. Int J Hyperthermia 23:513-527
24. Triantafilou M, Miyake K, Golenbock DT, Triantafilou K (2002) Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation. J Cell Sci 115:2603-2611
25. Sen A et al (2011) Mild elevation of body temperature reduces tumor interstitial fluid pressure and hypoxia and enhances efficacy of radiotherapy in murine tumor models. Cancer Res 71:3872-3880
26. Appenheimer MM et al (2007) Conservation of IL-6 trans-signaling mechanisms controlling L-selectin adhesion by fever-range thermal stress. Eur J Immunol 37:2856-2867
27. Vardam TD et al (2007) Regulation of a lymphocyte-endothelial-IL-6 trans-signaling axis by fever-range thermal stress: hot spot of immune surveillance. Cytokine 39:84-96
28. Fisher DT et al (2011) IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells. J Clin Invest 121:3846-3859
29. Oleson JR et al (1988) Biological and clinical aspects of hyperthermia in cancer therapy. Am J Clin Oncol 11:368-380
30. Westra A, Dewey WC (1971) Heat shock during the cell cycle of chinese hamster ovary cells in vitro. Int J Radiat Biol 19:467-477
31. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY (1998) Role of Hsp70in regulation of stress-kinase JNK: implications in apoptosis and aging. FEBS Lett 438 1-4
32. Gerner EW, Schneider MJ (1975) Induced thermal resistance in HeLa cells. Nature 256:500-502
33. Li GC, Hahn GM (1981) A proposed operational model for thermotolerance. Cancer Res 40:4501-4508
34. Craig EA (1985) The stress response: changes in eukaryotic gene expression in response to environmental stress. Science 230:800-801
35. Subjeck JR, Sciandra JJ, Johnson RJ (1982) Heat shock proteins and thermotolerance; a comparison of induction kinetics. Br J Radiol 55:579-584
36. Calderwood SK, Dickson JA (1983) pH and tumour response to hyperthermia. Adv Rad Biol 10:135-183
37. Song CW, Park H, Griffin, RJ (2001) Improvementoftumoroxygenationbymildhyperthermia. RadiatRes 155:515-528
38. Jones EL, Zhao MJ, Stevenson MA, Calderwood SK (2004) The 70 kDa heat shock protein is an inhibitor of apoptosis in prostate cancer. Int J Hyperthermia 20:835-849
39. Tang D et al (2005) Expression of heat shock proteins and heat shock protein messenger ribonucleic acid in human prostate carcinoma in vitro and in tumors in vivo. Cell Stress Chaperones 10:46-58
40. Mambula SS, Calderwood SK (2006b) Heat shock protein 70 is secreted from tumor cells by a nonclassical pathway involving lysosomal endosomes. J Immunol 177:7849-7857
41. Murshid A, Gong J, Calderwood SK (2010) Heat shock protein 90mediates efficient antigen cross presentation through the scavenger receptor expressed by endothelial cells-I. J Immunol 185:2903-2917
42. Dickson JA, Calderwood SK (1980) Temperature range and selective sensitivity of tumors to hyperthermia: a critical review. Ann NY Acad Sci 335:180-205
43. Zitvogel L et al (2004) Immune response against dying tumor cells. Adv Immunol 84:131-179
44. Tanaka K et al (2005) Intratumoral injection of immature dendritic cells enhances antitumor effect of hyperthermia using magnetic nanoparticles. Int J Cancer 116:624-633
45. Guo J et al (2007) Intratumoral injection of dendritic cells in combination with local hyperthermia induces systemic antitumor effect in patients with advanced melanoma. Int J Cancer 120:2418-2425
46. Mukhopadhaya A et al (2007) Localized hyperthermia combined with intratumoral dendritic cells induces systemic antitumor immunity. Cancer Res 67:7798-7806
47. Mambula SS, Calderwood SK (2006a) Heat induced release of Hsp70 from prostate carcinoma cells involves both active secretion and passive release from necrotic cells. Int J Hyperthermia 22:575-585
48. Skitzki JJ, Repasky EA, Evans SS (2009) Hyperthermia as an immunotherapy strategy for cancer. Curr Opin Investig Drugs 10:550-558
49. Hinshaw JL, Lee FT Jr (2004) Image-guided ablation of renal cell carcinoma. Magn Reson Imaging Clin N Am 12:429-447
50. Landry J, Marceau N (1978) Rate-limiting events in hyperthermic cell killing. Radiat Res 75:573-585
51. Mambula SS, Stevenson MA, Ogawa K, Calderwood SK (2007) Mechanisms for Hsp70 secretion: crossing membranes without aleader. Methods 43:168-175
52. Goldberg SN, Gazelle GS, Mueller PR (2000) Thermal ablation therapy for focal malignancy: a unified approach to underlying principles, techniques, and diagnostic imaging guidance. AJR Am J Roentgenol 174:323-331
53. Zerbini A et al (2008) Increased immunostimulatory activity conferred to antigen-presenting cells by exposure to antigen extract from hepatocellular carcinoma after radiofrequency thermal ablation. J Immunother 31:271-282
54. Zerbini A et al (2006) Radiofrequency thermal ablation of hepatocellular carcinoma liver nodules can activate and enhance tumor-specific T-cell responses. Cancer Res 66:1139-1146
55. Kottke T et al (2007) Induction of hsp70-mediated Th17 autoimmunity can be exploited as immunotherapy for metastatic prostate cancer. Cancer Res 67:11970-11979
56. Chen Z, Shen S, Peng B, Tao J (2009) Intratumoural GM-CSF microspheres and CTLA-4 blockade enhance the antitumour immunity induced by thermal ablation in a subcutaneous murine hepatoma model. Int J Hyperthermia 25:374-382
57. Waitz R et al (2012) Potent induction of tumor immunity by combining tumor cryoablation with anti-CTLA-4 therapy. Cancer Res 72:430-9