At what age does the risk for adverse maternal and infant outcomes increase? Nationwide register-based study on first births in Finland in 2005–2014

Acta Obstetricia et Gynecologica Scandinavica

Volumn 95, Issue 12, 2016, Pages 1368-1375

  Klemetti, Reija ^a,b   Gissler, Mika ^a,c   Sainio, Susanna ^d   Hemminki, Elina ^a,b  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c KAROLINSKA INSTITUTE   (Sweden)

^d FCR Blood Service   (Finland)

Author keywords

Advanced maternal age; adverse infant outcome; adverse maternal outcome; maternity care use; threshold age

Indexed keywords

ADULT; ADVERSE OUTCOME; APGAR SCORE; ARTICLE; CESAREAN SECTION; CHILD HEALTH; ECTOPIC PREGNANCY; FEMALE; FINLAND; HIGH RISK PREGNANCY; HOSPITAL CARE; HUMAN; INDUCED ABORTION; INFANT; INFANT WELFARE; INFERTILITY THERAPY; INSTRUMENTAL DELIVERY; LABOR INDUCTION; LOW BIRTH WEIGHT; MATERNAL AGE; MATERNAL CARE; MATERNAL HYPERTENSION; MATERNAL MORTALITY; MATERNAL WELFARE; MORTALITY RISK; NORMAL HUMAN; OBESITY; OUTCOME ASSESSMENT; PERINATAL DEATH; PERINATAL MORTALITY; PLACENTA PREVIA; PREGNANCY DIABETES MELLITUS; PREGNANCY OUTCOME; PREMATURE LABOR; PRIORITY JOURNAL; PUERPERIUM; RESPIRATORY CARE; RISK FACTOR; SMOKING; SOCIAL STATUS; SPONTANEOUS ABORTION; URBAN AREA; MIDDLE AGED; NEWBORN; ODDS RATIO; PREGNANCY; PREGNANCY COMPLICATIONS; REGISTER; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA;

ADULT; CESAREAN SECTION; FEMALE; FINLAND; HUMANS; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; LOGISTIC MODELS; MATERNAL AGE; MIDDLE AGED; ODDS RATIO; PERINATAL MORTALITY; PREGNANCY; PREGNANCY COMPLICATIONS; REGISTRIES; RISK FACTORS;

EID: 84995513557     PISSN: 00016349     EISSN: 16000412     Source Type: Journal    
DOI: 10.1111/aogs.13020     Document Type: Article

References (27)

1. Jacobsson B, Ladfors L, Milsom I. Advanced maternal age and adverse perinatal outcome. Obstet Gynecol. 2004;104:727–33.
2. Joseph KS, Allen AC, Dodds L, Turner LA, Scott H, Liston R. The perinatal effects of delayed childbearing. Obstet Gynecol. 2005;105:1410–8.
3. Cleary-Goldman J, Malone FD, Vidaver J, Ball RH, Nyberg DA, Comstock CH, et al. Impact of maternal age on obstetric outcome. Obstet Gynecol. 2005;105:983–90.
4. Schmidt L, Sobotka T, Bentzen JG, Nyboe Andersen A; on behalf of the ESHRE Reproduction and Society Task Force. Demographic and medical consequences of the postponement of parenthood. Hum Reprod Update. 2012;18:29–43.
5. Mathews TJ, Hamilton BE. First births to older women continue to rise. NCHS Data Brief. 2014;15:1–7.
6. Medical Birth Register, THL, 2014. Available online at: http://www.thl.fi/en/statistics/parturients (accessed May 21, 2015)
7. Hemminki E, Gissler M. Births by younger and older mothers in a population with late and regulated childbearing: Finland 1991. Acta Obstet Gynecol Scand. 1996;75:19–27.
8. Reichman NE, Pagnini DL. Maternal age and birth outcomes: data from New Jersey. Fam Plann Perspect. 1997;29:268–72.
9. Delbaere I, Verstraelen H, Goetgeluk S, Martens G, De Backer G, Temmerman M. Pregnancy outcome in primiparae of advanced maternal age. Eur J Obstet Gynecol Reprod Biol. 2007;135:41–6.
10. Luke B, Brown MB. Elevated risks of pregnancy complications and adverse outcomes with increasing maternal age. Hum Reprod. 2007;22:1264–72.
11. Roberts CL, Ford JB, Algert CS, Bell JC, Simpson JM, Morris JM. Trends in adverse maternal outcomes during childbirth: a population-based study of severe maternal morbidity. BMC Pregnancy Childbirth. 2009;9:7.
12. Yaniv SS, Levy A, Wiznitzer A, Holcberg G, Mazor M, Sheiner E. A significant linear association exists between advanced maternal age and adverse perinatal outcome. Arch Gynecol Obstet. 2011;283:755–9.
13. Kenny LC, Lavender T, McNamee R, O'Neill SM, Mills T, Khashan AS. Advanced maternal age and adverse pregnancy outcome: evidence from a large contemporary cohort. PLoS ONE. 2013;8:e56583.
14. Klemetti R, Gissler M, Sainio S, Hemminki E. Associations of maternal age with maternity care use and birth outcomes in primiparous women: a comparison of results in 1991 and 2008 in Finland. BJOG. 2014;121:356–62.
15. Waldenström U, Aasheim V, Vika Nilsen AB, Rasmussen S, Pettersson HJ, Shytt E. Adverse pregnancy outcomes related to advanced maternal age compared with smoking and being overweight. Obstet Gynecol. 2014;123:104–11.
16. Schimmel MS, Bromiker R, Hammerman C, Chertman L, Ioscovich A, Granovsky-Grisaru S, et al. The effects of maternal age and parity on maternal and neonatal outcome. Arch Gynecol Obstet. 2015;291:793–8.
17. Blanc AK, Winfrey W, Ross J. New findings for maternal mortality age patterns: aggregated results for 38 countries. PLoS ONE. 2013;8:e59864.
18. Teperi J. Multi method approach to the assessment of data quality in the Finnish Medical Birth Registry. J Epidemiol Community Health. 1993;47:242–7.
19. Gissler M, Teperi J, Hemminki E, Meriläinen J. Data quality after restructuring a national medical registry. Scand J Soc Med. 1995;23:75–80.
20. Lawlor DA, Mortensen L, Nybo Andersen AM. Mechanisms underlying the associations of maternal age with adverse perinatal outcomes: a sibling study of 264 695 Danish women and their firstborn offspring. Int J Epidemiol. 2011;40:1205–14.
21. Leppälahti S, Gissler M, Mentula M, Heikinheimo O. Is teenage pregnancy an obstetric risk in a welfare society? A population-based study in Finland, from 2006 to 2011. BMJ Open. 2013;3:e003225.
22. Patel RR, Peters TJ, Murphy DJ; the ALSPAC Study Team. Prenatal risk factors for Caesarean section. Analyses of the ALSPAC cohort of 12 944 women in England. Int J Epidemiol. 2005;34:353–67.
23. Hoffman MC, Jeffers S, Carter J, Duthely L, Cotter A, González-Quintero VH. Pregnancy at or beyond age 40 years is associated with an increased risk of fetal death and other adverse outcomes. Am J Obstet Gynecol. 2007;196:e11–3.
24. Duckitt K, Harrington D. Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. BMJ. 2005;330:565.
25. Drugs and pregnancy, THL, 2015. Available online at: www.thl.fi/drugsandpregnancy, (accessed April 16, 2015)
26. Nybo Andersen AM, Wohlfart J, Christens P, Olsen J, Melbye M. Maternal age and fetal loss: population based register linkage study. BMJ. 2000;320:1708–12.
27. Dowswell T, Carroli G, Duley L, Gates S, Gülmezoglu AM, Khan-Neelofur D, et al. Alternative versus standard packages of antenatal care for low-risk pregnancy. Cochrane Database Syst Rev. 2015:CD000934.