From lead optimization to NDA approval for a new antimicrobial: Use of pre-clinical effect models and pharmacokinetic/pharmacodynamic mathematical modeling

Bioorganic and Medicinal Chemistry

Volumn 24, Issue 24, 2016, Pages 6401-6408

  Drusano, G L ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

Mathematical modeling; Pharmacodynamics; Resistance suppression

Indexed keywords

ANTIINFECTIVE AGENT; LINEZOLID; MEROPENEM; OSELTAMIVIR; OXAZOLIDINONE; RALTEGRAVIR; UNCLASSIFIED DRUG; ZANAMIVIR;

AREA UNDER THE CURVE; ARTICLE; DOSAGE SCHEDULE COMPARISON; DRUG CLEARANCE; DRUG HALF LIFE; DRUG POTENCY; EC50; HOLLOW FIBER INFECTION MODEL; MATHEMATICAL MODEL; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PSEUDOMONAS PNEUMONIA; VOLUME OF DISTRIBUTION; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; DRUG APPROVAL; DRUG DEVELOPMENT; DRUG EFFECTS; HUMAN; MICROBIAL SENSITIVITY TEST; PSEUDOMONAS INFECTIONS; SYNTHESIS;

ANIMALS; ANTI-BACTERIAL AGENTS; DRUG APPROVAL; DRUG DISCOVERY; HUMANS; MICROBIAL SENSITIVITY TESTS; MODELS, BIOLOGICAL; MYCOBACTERIUM TUBERCULOSIS; PSEUDOMONAS INFECTIONS;

EID: 84995476952     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2016.08.034     Document Type: Article

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