Myocardial Fibrosis Assessment by LGE Is a Powerful Predictor of Ventricular Tachyarrhythmias in Ischemic and Nonischemic LV Dysfunction: A Meta-Analysis

JACC: Cardiovascular Imaging

Volumn 9, Issue 9, 2016, Pages 1046-1055

  Disertori, Marcello ^a,b   Rigoni, Marta ^b   Pace, Nicola ^b   Casolo, Giancarlo ^c   Masè, Michela ^d   Gonzini, Lucio ^e   Lucci, Donata ^e   Nollo, Giandomenico ^b   Ravelli, Flavia ^d  

^a SANTA CHIARA HOSPITAL   (Italy)

^b FONDAZIONE BRUNO KESSLER   (Italy)

^c Versilia Hospital   (Italy)

^d UNIVERSITY OF TRENTO   (Italy)

^e Italian Association of Hospital Cardiologists Research Center   (Italy)

Author keywords

cardiac magnetic resonance; implantable cardioverter defibrillator; late gadolinium enhancement; sudden death; ventricular tachyarrhythmias

Indexed keywords

GADOLINIUM; CONTRAST MEDIUM;

ARTICLE; CARDIOVASCULAR MAGNETIC RESONANCE; CLINICAL ASSESSMENT; CLINICAL OUTCOME; CONTRAST ENHANCEMENT; DATA BASE; FOLLOW UP; HEART EJECTION FRACTION; HEART MUSCLE FIBROSIS; HEART PACING; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HUMAN; IMPLANTABLE CARDIOVERTER DEFIBRILLATOR; ISCHEMIC CARDIOMYOPATHY; NONISCHEMIC CARDIOMYOPATHY; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGNOSIS; RISK FACTOR; SUDDEN DEATH; AGED; ARRHYTHMIAS, CARDIAC; CARDIAC MUSCLE; CHI SQUARE DISTRIBUTION; COMPLICATION; DIAGNOSTIC IMAGING; FEMALE; FIBROSIS; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE ISCHEMIA; HEART STROKE VOLUME; MALE; META ANALYSIS; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; ODDS RATIO; PATHOLOGY; PATHOPHYSIOLOGY; RISK ASSESSMENT; STATISTICAL MODEL; TIME FACTOR;

AGED; ARRHYTHMIAS, CARDIAC; CHI-SQUARE DISTRIBUTION; CONTRAST MEDIA; FEMALE; FIBROSIS; GADOLINIUM; HUMANS; LINEAR MODELS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; MYOCARDIUM; ODDS RATIO; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RISK ASSESSMENT; RISK FACTORS; STROKE VOLUME; TIME FACTORS; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT;

EID: 84994891854     PISSN: 1936878X     EISSN: 18767591     Source Type: Journal    
DOI: 10.1016/j.jcmg.2016.01.033     Document Type: Article

References (39)

1. 1 Epstein, A.E., DiMarco, J.P., Ellenbogen, K.A., et al. 2012 ACCF/AHA/HRS focused update incorporated into the ACCF/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol 61 (2013), e6–e75.
2. 2 Hartikainen, J.E., Malik, M., Staunton, A., Poloniecki, J., Camm, A.J., Distinction between arrhythmic and nonarrhythmic death after acute myocardial infarction based on heart rate variability, signal-averaged electrocardiogram, ventricular arrhythmias and left ventricular ejection fraction. J Am Coll Cardiol 28 (1996), 296–304.
3. 3 Buxton, A.E., Lee, K.L., Hafley, G.E., et al. Limitations of ejection fraction for prediction of sudden risk death in patients with coronary artery disease: lessons from the MUSTT study. J Am Coll Cardiol 50 (2007), 1150–1157.
4. 4 Gorgels, A.P., Gijsbers, C., de Vreede-Swagemakers, J., Lousberg, A., Wellens, H.J., Out-of-hospital cardiac arrest–the relevance of heart failure. The Maastricht Circulatory Arrest Registry. Eur Heart J 24 (2003), 1204–1209.
5. 5 Bello, D., Fieno, D.S., Kim, R.J., et al. Infarct morphology identifies patients with substrate for sustained ventricular tachycardia. J Am Coll Cardiol 45 (2005), 1104–1108.
6. 6 Wu, T.J., Ong, J.J., Hwang, C., et al. Characteristics of wave fronts during ventricular fibrillation in human hearts with dilated cardiomyopathy: role of increased fibrosis in the generation of reentry. J Am Coll Cardiol 32 (1998), 187–196.
7. 7 Bogun, F.M., Desjardins, B., Good, E., et al. Delayed-enhanced magnetic resonance imaging in nonischemic cardiomyopathy: utility for identifying the ventricular arrhythmia substrate. J Am Coll Cardiol 53 (2009), 1138–1145.
8. 8 Roes, S.D., Borleffs, C.J., van der Geest, R.J., et al. Infarct tissue heterogeneity assessed with contrast-enhanced MRI predicts spontaneous ventricular arrhythmias in patients with ischemic cardiomyopathy and implantable cardioverter-defibrillator. Circ Cardiovasc Imaging 2 (2009), 183–190.
9. 9 Gao, P., Yee, R., Gula, L., et al. Prediction of arrhythmic events in ischemic and dilated cardiomyopathy patients referred for implantable cardiac defibrillator: evaluation of multiple scar quantification measures for late gadolinium enhancement magnetic resonance imaging. Circ Cardiovasc Imaging 5 (2012), 448–456.
10. 10 Klem, I., Weinsaft, J.W., Bahnson, T.D., et al. Assessment of myocardial scarring improves risk stratification in patients evaluated for cardiac defibrillator implantation. J Am Coll Cardiol 60 (2012), 408–420.
11. 11 Gulati, A., Jabbour, A., Ismail, T.F., et al. Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy. JAMA 309 (2013), 896–908.
12. 12 Liberati, A., Altman, D.G., Tetzlaff, J., et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 62 (2009), e1–e34.
13. 13 Boyé, P., Abdel-Aty, H., Zacharzowsky, U., et al. Prediction of life-threatening arrhythmic events in patients with chronic myocardial infarction by contrast-enhanced CMR. J Am Coll Cardiol Img 4 (2011), 871–879.
14. 14 De Hann, S., Meijers, T.A., Knaapen, P., Beek, A.M., van Rossum, A.C., Allart, C.P., Scar size and characteristics assessed by CMR predict ventricular arrhythmias in ischaemic cardiomyopathy: comparison of previously validated models. Heart 97 (2011), 1951–1956.
15. 15 Alexandre, J., Saloux, E., Dugué, A.E., et al. Scar extent evaluated by late gadolinium enhancement CMR: a powerful predictor of long term appropriate ICD therapy in patients with coronary artery disease. J Cardiovasc Magn Reson, 15, 2013, 12.
16. 16 Demirel, F., Adiyaman, A., Timmer, J.R., et al. Myocardial scar characteristics based on cardiac magnetic resonance imaging is associated with ventricular tachyarrhythmia in patients with ischemic cardiomyopathy. Int J Cardiol 177 (2014), 392–399.
17. 17 Assomull, R.G., Prasad, S.K., Lyne, J., et al. Cardiovascular magnetic resonance, fibrosis, and prognosis in dilated cardiomyopathy. J Am Coll Cardiol 48 (2006), 1977–1985.
18. 18 Iles, L., Pfluger, H., Lefkovits, L., et al. Myocardial fibrosis predicts appropriate device therapy in patients with implantable cardioverter-defibrillators for primary prevention of sudden cardiac death. J Am Coll Cardiol 57 (2011), 821–828.
19. 19 Leyva, F., Taylor, R.J., Foley, P.W., et al. Left ventricular midwall fibrosis as a predictor of mortality and morbidity after cardiac resynchronization therapy in patients with nonischemic cardiomyopathy. J Am Coll Cardiol 60 (2012), 1659–1667.
20. 20 Neilan, T.G., Coelho-Filho, O.R., Danik, S.B., et al. CMR quantification of myocardial scar provides additive prognostic information in nonischemic cardiomyopathy. J Am Coll Cardiol Img 6 (2013), 944–954.
21. 21 Muller, K.A., Muller, I., Kramer, U., et al. Prognostic value of contrast-enhanced cardiac magnetic resonance imaging in patients with newly diagnosed non-ischemic cardiomyopathy: cohort study. PLoS One, 8, 2013, e57077.
22. 22 Perazzolo Marra, M., De Lazzari, M., Zorzi, A., et al. Impact of the presence and amount of myocardial fibrosis by cardiac magnetic resonance on arrhythmic outcome and sudden cardiac death in nonischemic dilated cardiomyopathy. Heart Rhythm 11 (2014), 856–863.
23. 23 Masci, P.G., Doulaptsis, C., Bertella, E., et al. Incremental prognostic value of myocardial fibrosis in patients with non-ischemic cardiomyopathy without congestive heart failure. Circ Heart Fail 7 (2014), 448–456.
24. 24 Fernandez-Armenta, J., Berruezo, A., Mont, L., et al. Use of myocardial scar characterization to predict ventricular arrhythmia in cardiac resynchronization therapy. Europace 14 (2012), 1578–1586.
25. 25 Wu, K.C., Gerstenblith, G., Guallar, E., et al. Combined cardiac magnetic resonance imaging and C-reactive protein levels identify a cohort at low risk for defibrillation firings and death. Circ Cardiovasc Imaging 5 (2012), 178–186.
26. 26 Mordi, I., Jhund, P.S., Gardner, R.S., et al. LGE and NT-proBNP identify low risk of death or arrhythmic events in patients with primary prevention ICDs. J Am Coll Cardiol Img 7 (2014), 561–569.
27. 27 Almehmadi, F., Joncas, S.X., Nevis, I., et al. Prevalence of myocardial fibrosis patterns in patients with systolic dysfunction: prognostic significance for the prediction of sudden cardiac arrest or appropriate implantable cardiac defibrillator therapy. Circ Cardiovasc Imaging 7 (2014), 593–600.
28. 28 Wells GA, Shea B, O'Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Available at: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed April 16, 2015.
29. 29 DerSimonian, R., Laird, N., Meta-analysis in clinical trials. Controlled Clinical Trials 7 (1986), 177–188.
30. 30 Sterne, J.A.C., Sutton, A.J., Ioannidis, J.P.A., et al. Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomized controlled trials. BMJ, 343, 2011, d4002.
31. 31 Chu, H., Cole, S.R., Bivariate meta-analysis of sensitivity and specificity with sparse data: a generalized linear mixed model approach. J Clin Epidemiol 59 (2006), 1331–1332.
32. 32 Mann, D.L., Bristow, M.R., Mechanisms and models in heart failure: the biomechanical model and beyond. Circulation 111 (2005), 2837–2849.
33. 33 Iles, L.M., Ellims, A.H., Llewellyn, H., et al. Histological validation of cardiac magnetic resonance analysis of regional and diffuse interstitial myocardial fibrosis. Eur Heart J Cardiovasc Imaging 16 (2015), 14–22.
34. 34 Schmidt, A., Azevedo, C.F., Cheng, A., et al. Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmias susceptibility in patients with left ventricular dysfunction. Circulation 115 (2007), 2006–2014.
35. 35 Perez-David, E., Arenal, A., Rubio-Guivernau, J.L., et al. Noninvasive identification of ventricular tachycardia-related conduction channel using contrast-enhanced magnetic resonance imaging in patients with chronic myocardial infarction: comparison of signal intensity scar mapping and endocardial voltage mapping. J Am Coll Cardiol 57 (2011), 184–194.
36. 36 Kwong, R.Y., Farzaneh-Far, A., Measuring myocardial scar by CMR. J Am Coll Cardiol Img 4 (2011), 157–160.
37. 37 Disertori, M., Quintarelli, S., Mazzola, S., Favalli, V., Narula, N., Arbustini, E., The need to modify patient selection to improve the benefits of implantable cardioverter-defibrillator for primary prevention of sudden death in non-ischaemic dilated cardiomyopathy. Europace 15 (2013), 1693–1701.
38. 38 Ellenbogen, K.A., Levine, J.H., Berger, R.D., et al. Are implantable cardioverter defibrillator shocks a surrogate for sudden cardiac death in patients with nonischemic cardiomyopathy?. Circulation 113 (2006), 776–782.
39. 39 Persson, R., Earley, A., Garlitski, A.C., Balk, E.M., Uhlig, K., Adverse events following implantable cardioverter defibrillator implantation: a systematic review. J Interv Card Electrophysiol 40 (2014), 191–205.