Straightforward Glycoengineering Approach to Site-Specific Antibody-Pyrrolobenzodiazepine Conjugates

ACS Medicinal Chemistry Letters

Volumn 7, Issue 11, 2016, Pages 1005-1008

  Thompson, Pamela ^a   Ezeadi, Ebele ^b   Hutchinson, Ian ^b   Fleming, Ryan ^a   Bezabeh, Binyam ^a   Lin, Jia ^a   Mao, Shenlan ^a   Chen, Cui ^a   Masterson, Luke ^b   Zhong, Haihong ^a   Toader, Dorin ^a   Howard, Philip ^b   Wu, Herren ^a   Gao, Changshou ^a   Dimasi, Nazzareno ^a  

^a MEDIMMUNE   (United States)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Antibody drug conjugates; carbohydrate remodeling; click chemistry; pyrrolobenzodiazepine; SG3364; site specific conjugation

Indexed keywords

ANTIBODY; BENZODIAZEPINE DERIVATIVE; PYRROLOBENZODIAZEPINE; UNCLASSIFIED DRUG;

ARTICLE; CLICK CHEMISTRY; CYTOTOXICITY; DRUG CONJUGATION; GLYCOSYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER CELL LINE;

EID: 84994891139     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.6b00278     Document Type: Article

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