PLA2R antibodies, glomerular PLA2R deposits and variations in PLA2R1 and HLA-DQA1 genes in primary membranous nephropathy in South Asians

Nephrology Dialysis Transplantation

Volumn 31, Issue 9, 2016, Pages 1486-1493

  Ramachandran, Raja ^a   Kumar, Vinod ^a   Kumar, Ashwani ^a   Yadav, Ashok Kumar ^a   Nada, Ritambhra ^a   Kumar, Harsha ^a   Kumar, Vivek ^a   Rathi, Manish ^a   Kohli, Harbir Singh ^a   Gupta, Krishan Lal ^a   Sakhuja, Vinay ^a   Jha, Vivekanand ^a,b,c  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^b GEORGE INSTITUTE FOR GLOBAL HEALTH   (Australia)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

autoantibodies; glomerulonephritis; membranous nephropathy; nephrotic syndrome; proteinuria

Indexed keywords

ALKYLATING AGENT; ANGIOTENSIN ANTAGONIST; CALCINEURIN INHIBITOR; CORTICOSTEROID; CYCLOPHOSPHAMIDE; HLA DQA1 ANTIGEN; PHOSPHOLIPASE A2 RECEPTOR; PHOSPHOLIPASE A2 RECEPTOR ANTIBODY; RECEPTOR ANTIBODY; STEROID; UNCLASSIFIED DRUG; AUTOANTIBODY; HLA DQ ANTIGEN; HLA-DQA1 ANTIGEN; PLA2R1 PROTEIN, HUMAN;

ADOLESCENT; ADULT; AGED; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; CHILD; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FROZEN SECTION; GENE; GENETIC ASSOCIATION; GENETIC VARIATION; GENOTYPE; HIGH RISK PATIENT; HISTOPATHOLOGY; HLA DQA1 GENE; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; INDIAN; MAJOR CLINICAL STUDY; MALE; MEMBRANOUS GLOMERULONEPHRITIS; MULTIPLE CYCLE TREATMENT; NEPHROTIC SYNDROME; OUTCOME ASSESSMENT; PHOSPHOLIPASE A2 RECEPTOR ANTIBODY BLOOD LEVEL; PLA2R1 GENE; PRIMARY MEMBRANOUS NEPHROPATHY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN LOCALIZATION; REMISSION; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; CASE CONTROL STUDY; COMPARATIVE STUDY; GENETICS; IMMUNOLOGY; MIDDLE AGED; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; AUTOANTIBODIES; CASE-CONTROL STUDIES; CHILD; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENOTYPE; GLOMERULONEPHRITIS, MEMBRANOUS; HLA-DQ ALPHA-CHAINS; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; RECEPTORS, PHOSPHOLIPASE A2; YOUNG ADULT;

EID: 84994881367     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfv399     Document Type: Article

References (19)

1. Rathi M, Bhagat RL, Mukhopadhyay P et al. Changing histologic spectrum of adult nephrotic syndrome over five decades in north India: a single center experience. Indian J Nephrol 2014; 24: 86-91
2. Beck LH, Jr, Bonegio RG, Lambeau G et al. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med 2009; 361: 11-21
3. Hoxha E, Thiele I, Zahner G et al. Phospholipase A2 receptor autoantibodies and clinical outcome in patients with primary membranous nephropathy. J Am Soc Nephrol 2014; 25: 1357-1366
4. Stanescu HC, Arcos-Burgos M, Medlar A et al. Risk HLA-DQA1 and PLA (2)R1 alleles in idiopathic membranous nephropathy. N Engl J Med 2011; 364: 616-626
5. Hofstra JM, Debiec H, Short CD et al. Antiphospholipase A2 receptor antibody titer and subclass in idiopathic membranous nephropathy. J Am Soc Nephrol 2012; 23: 1735-1743
6. Hoxha E, Kneissler U, Stege G et al. Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy. Kidney Int 2012; 82: 797-804
7. Lv J, Hou W, Zhou X et al. Interaction between PLA2R1 and HLA-DQA1 variants associates with anti-PLA2R antibodies and membranous nephropathy. J Am Soc Nephrol 2013; 24: 1323-1329
8. Coenen MJ, Hofstra JM, Debiec H et al. Phospholipase A2 receptor (PLA2R1) sequence variants in idiopathic membranous nephropathy. J Am Soc Nephrol 2013; 24: 677-683
9. Radhakrishnan J, Cattran DC. The KDIGO practice guideline on glomerulonephritis: reading between the (guide)lines - application to the individual patient. Kidney Int 2012; 82: 840-856
10. KumarV, Ramachandran R, KumarAet al. Antibodies to m-type phospholipase A2 receptor in children with idiopathic membranous nephropathy. Nephrology (Carlton) 2015; 20: 572-575
11. Ramachandran R, Kumar V, Rathi M et al. Tacrolimus therapy in adult-onset steroid-resistant nephrotic syndrome due to a focal segmental glomerulosclerosis single-center experience. Nephrol Dial Transplant 2014; 29: 1918-1924
12. Debiec H, Ronco P. PLA2R autoantibodies and PLA2R glomerular deposits in membranous nephropathy. N Engl J Med 2011; 364: 689-690
13. Hoxha E, Harendza S, Zahner G et al. An immunofluorescence test for phospholipase-A(2)-receptor antibodies and its clinical usefulness in patients with membranous glomerulonephritis. Nephrol Dial Transplant 2011; 26: 2526-2532
14. QinW, Beck LH, Jr, Zeng C et al. Anti-phospholipase A2 receptor antibody in membranous nephropathy. J Am Soc Nephrol 2011; 22: 1137-1143
15. Svobodova B, Honsova E, Ronco P et al. Kidney biopsy is a sensitive tool for retrospective diagnosis of PLA2R-related membranous nephropathy. Nephrol Dial Transplant 2013; 28: 1839-1844
16. van de Logt AE, Hofstra JM,Wetzels JF. Serum anti-PLA2R antibodies can be initially absent in idiopathic membranous nephropathy: seroconversion after prolonged follow-up. Kidney Int 2015; 87: 1263-1264
17. Ruggenenti P, Debiec H, Ruggiero B et al. Anti-phospholipase A2 receptor antibody titer predicts post-rituximab outcome of membranous nephropathy. J Am Soc Nephrol 2015; 26: 2545-2558
18. Bech AP, Hofstra JM, Brenchley PE et al. Association of anti-PLA(2)R antibodies with outcomes after immunosuppressive therapy in idiopathic membranous nephropathy. Clin J Am Soc Nephrol 2014; 9: 1386-1392
19. JhaV,Ganguli A, Saha TKet al. Arandomized, controlled trial of steroids and cyclophosphamide in adults with nephrotic syndrome caused by idiopathic membranous nephropathy. J Am Soc Nephrol 2007; 18: 1899-1904