Dectin-1-activated dendritic cells: A potent Th9 cell inducer for tumor immunotherapy

OncoImmunology

Volumn 5, Issue 11, 2016, Pages

  Chen, Jintong ^a   Zhao, Yinghua ^a   Chu, Xiao ^a   Lu, Yong ^b   Wang, Siqing ^a   Yi, Qing ^a,b  

^a THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Antitumor immunity; Dectin 1; dentritic cells; Th9; Vaccine

Indexed keywords

CURDLAN; DECTIN 1; DENDRITIC CELL VACCINE; INTERLEUKIN 9; OX40 LIGAND; SCLEROGLUCAN; VASCULAR ENDOTHELIAL GROWTH INHIBITOR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW DERIVED DENDRITIC CELL; CANCER IMMUNIZATION; CELL DIFFERENTIATION; CYTOTOXIC T LYMPHOCYTE; HUMAN; MELANOMA; MYELOMA; NEOPLASM; NONHUMAN; PROTEIN EXPRESSION; TH9 CELL;

EID: 84994852912     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.1080/2162402X.2016.1238558     Document Type: Article

References (10)

1. Kantoff PW, Higano CS, Shore ND, Berger ER, Small EJ, Penson DF, Redfern CH, Ferrari AC, Dreicer R, Sims RB, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med 2010; 363(5):411-22; PMID:20818862; doi:10.1056/NEJMoa1001294
2. Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, et al. Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat Med 2012; 18(8):1248-53; PMID:22772464; doi:10.1038/nm.2856
3. Lu Y, Hong S, Li H, Park J, Hong B, Wang L, Zheng Y, Liu Z, Xu J, He J, et al. Th9 cells promote antitumor immune responses in vivo. J Clin Invest 2012; 122(11):4160-71; PMID:23064366; doi:10.1172/JCI65459
4. Lu Y, Q Yi. Utilizing TH9 cells as a novel therapeutic strategy for malignancies. Oncoimmunology 2013; 2(3):e23084; PMID:23802062; doi:10.4161/onci.23084
5. Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB. Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk. Nat Immunol 2009; 10(2):203-13; PMID:19122653; doi:10.1038/ni.1692
6. Taylor PR, Brown GD, Reid DM, Willment JA, Martinez-Pomares L, Gordon S, Wong SY. The β-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages. J Immunol 2002; 169(7):3876-82; PMID:12244185; doi:10.4049/jimmunol.169.7.3876
7. Zhao Y, Chu X, Chen J, Wang Y, Gao S, Jiang Y, Zhu X, Tan G, Zhao W, Yi H, et al. Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells. Nat Commun 2016; 7:12368; PMID:27492902; doi:10.1038/ncomms12368
8. O'Shea JJ, Lahesmaa R, Vahedi G, Laurence A, Kanno Y. Genomic views of STAT function in CD4+ T helper cell differentiation. Nat Rev Immunol 2011; 11(4):239-50; PMID:21436836; doi:10.1038/nri2958
9. Xiao X, Balasubramanian S, Liu W, Chu X, Wang H, Taparowsky EJ, Fu YX, Choi Y, Walsh MC, Li XC. OX40 signaling favors the induction of T(H)9 cells and airway inflammation. Nat Immunol 2012; 13(10):981-90; PMID:22842344; doi:10.1038/ni.2390
10. Richard AC, Tan C, Hawley ET, Gomez-Rodriguez J, Goswami R, Yang XP, Cruz AC, Penumetcha P, Hayes ET, Pelletier M, et al. The TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells. J Immunol 2015; 194(8):3567-82; PMID:25786692; doi:10.4049/jimmunol.1401220