Biased estimates of clonal evolution and subclonal heterogeneity can arise from PCR duplicates in deep sequencing experiments

Genome biology

Volumn 15, Issue 8, 2014, Pages 420-

  Smith, Erin N ^a   Jepsen, Kristen ^a   Khosroheidari, Mahdieh ^a   Rassenti, Laura Z ^a   D'Antonio, Matteo ^a   Ghia, Emanuela M ^a   Carson, Dennis A ^a   Jamieson, Catriona H m ^a   Kipps, Thomas J ^a   Frazer, Kelly A ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHRONIC LYMPHATIC LEUKEMIA; CLONAL EVOLUTION; DNA SEQUENCE; GENE FREQUENCY; GENETIC HETEROGENEITY; GENETICS; HIGH THROUGHPUT SEQUENCING; HUMAN; LABORATORY DIAGNOSIS; POLYMERASE CHAIN REACTION; PROCEDURES; SOFTWARE;

CLONAL EVOLUTION; FALSE POSITIVE REACTIONS; GENE FREQUENCY; GENETIC HETEROGENEITY; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; SOFTWARE;

EID: 84994850922     PISSN: None     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-014-0420-4     Document Type: Article

References (0)