Mechanobiology of Cutaneous Wound Healing and Scarring

Studies in Mechanobiology, Tissue Engineering and Biomaterials

Volumn 1, Issue , 2009, Pages 31-42

  Ogawa, Rei ^a,b   Orgill, Dennis P ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Cutaneous Wound Healing; Hydrostatic Pressure Gradient; Mechanical Force; Neurogenic Inflammation; Skin Tension

Indexed keywords

EID: 84994513378     PISSN: 18682006     EISSN: 18682014     Source Type: Book Series    
DOI: 10.1007/978-3-642-00534-3_2     Document Type: Chapter

References (39)

1. Aarabi, S., Bhatt, K.A., Shi, Y., Paterno, J., Chang, E.I., Loh, S.A., Holmes, J.W., Longaker, M.T., Yee, H., Gurtner, G.C.: Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis. FASEB J. 21, 3250–3261 (2007)
2. Akaishi, S., Akimoto, M., Ogawa, R., Hyakusoku, H.: The relationship between keloid growth pattern and stretching tension: visual analysis using the finite element method. Ann. Plast. Surg. 60(4), 445–451 (2008)
3. Akaishi, S., Ogawa, R., Hyakusoku, H.: Keloid and hypertrophic scar: neurogenic inflammation hypotheses. Med. Hypotheses 71(1), 32–38 (2008)
4. Bender, A.E., Bender, D.A.: Body Surface Area. A Dictionary of Food and Nutrition. Oxford University Press, New York (1995)
5. Chin, M.S., Lancerotto, L., Helm, D., Dastouri, P., Prsa, M.J., Ottensmeyer, M., Akaishi, S., Orgill, D.P., Ogawa, R.: Analysis of Neuropeptides in Stretched Skin. Plast. Reconstructive Surg (in Press, 2009)
6. Couchman, J.R., Austria, M.R., Woods, A.: Fibronectin-cell interactions. J. Invest. Dermatol. 94(suppl. 6), S7–S14 (1990)
7. Daya, M., Nair, V.: Traction-assisted dermatogenesis by serial intermittent skin tape application. Plast. Reconstr. Surg. 122(4), 1047–1054 (2008)
8. Denda, M., Nakatani, M., Ikeyama, K., Tsutsumi, M., Denda, S.: Epidermal keratinocytes as the forefront of the sensory system. Exp. Dermatol. 16(3), 157–161 (2007)
9. Elwood, E.T., Ingram, W.L., Carlson, G.W.: Pregnancy as a tissue expander in the repair of a massive ventral hernia. Ann. Plast. Surg. 45(4), 431–433 (2000)
10. Gao, J.H., Ogawa, R., Hyakusoku, H., Lu, F., Hu, Z.Q., Jiang, P., Yang, L., Feng, C.: Reconstruction of the face and neck scar contractures using staged transfer of expanded "Super-thin flaps". Burns 33(6), 760–763 (2007)
11. Giamarchi, A., Padilla, F., Crest, M., Honore, E., Delmas, P.: TRPP2: Ca2+-permeable cation channel and more. Cell. Mol. Biol. (Noisy-le-grand) 52(8), 105–114 (2006)
12. Gilbert, T.W., Stewart-Akers, A.M., Sydeski, J., Nguyen, T.D., Badylak, S.F., Woo, S.L.: Gene expression by fibroblasts seeded on small intestinal submucosa and subjected to cyclic stretching. Tissue Eng. 13(6), 1313–1323 (2007)
13. Greene, A.K., Puder, M., Roy, R., Arsenault, D., Kwei, S., Moses, M.A., Orgill, D.P.: Microdeformational wound therapy: effects on angiogenesis and matrix metalloproteinases in chronic wounds of 3 debilitated patients. Ann. Plast. Surg. 56(4), 418–422 (2006)
14. Hamill, O.P.: Twenty odd years of stretch-sensitive channels. Pflugers Arch. 453(3), 333–351 (2006)
15. Hinz, B., Celetta, G., Tomasek, J.J., Gabbiani, G., Chaponnier, C.: Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol. Biol. Cell 12, 2730 (2001)
16. Inoue, R., Jensen, L.J., Shi, J., Morita, H., Nishida, M., Honda, A., Ito, Y.: Transient receptor potential channels in cardiovascular function and disease. Circ. Res. 99(2), 119–131 (2006)
17. Jancso, N., Janxso-Gabor, A., Szolxsanyi, J.: Direct evidence for neurogenic inflammation and its prevention by denermation and by pre-treatment with capsaicin. Br. J. Pharmacol. 31, 138–151 (1967)
18. Kessler, D., Dethlefsen, S., Haase, I., Plomann, M., Hirche, F., Krieg, T., Eckes, B.: Fibroblasts in mechanically stressed collagen lattices assume a "synthetic" phenotype. J. Biol. Chem. 276(39), 36575–36585 (2001)
19. Lai, X.N., Wang, Z.G., Zhu, J.M., Wang, L.L.: Effect of substance P on gene expression of transforming growth factor beta-1 and its receptors in rat’s fibroblasts. Chin. J. Traumatol. 6(6), 350–354 (2003)
20. Lund, T., Onarheim, H., Reed, R.K.: Pathogenesis of edema formation in burn injuries. World J. Surg. 16(1), 2–9 (1992)
21. Manders, E.K., Schenden, M.J., Furrey, J.A., Hetzler, P.T., Davis, T.S., Graham, W.P.: 3rd, Soft-tissue expansion: concepts and complications. Plast. Reconstr. Surg. 74(4), 493–507 (1984)
22. Matthews, B.D., Overby, D.R., Mannix, R., Ingber, D.E.: Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels. J. Cell. Sci. 119(Pt 3), 508–518 (2006)
23. Ogawa, R., Chin, M.S.: Animal models of keloids and hypertrophic scars. J. Burn. Care Res. 29(6), 1016–1017 (2008)
24. Ogawa, R., Mitsuhashi, K., Hyakusoku, H., Miyashita, T.: Postoperative electron-beam irradiation therapy for keloids and hypertrophic scars: retrospective study of 147 cases followed for more than 18 months. Plast. Reconstr. Surg. 111(2), 547–553 (2003)
25. Ogawa, R.: Keloid and hypertrophic scarring may result from a mechanoreceptor or mechanosensitive nociceptor disorder. Med. Hypotheses 71(4), 493–500 (2008)
26. Parsons, M., Kessler, E., Laurent, G.J., Brown, R.A., Bishop, J.E.: Mechanical load enhances procollagen processing in dermal fibroblasts by regulating levels of procollagen C-proteinase. Exp. Cell. Res. 252(2), 319–331 (1999)
27. Pietramaggiori, G., Liu, P., Scherer, S.S., Kaipainen, A., Prsa, M.J., Mayer, H., Newalder, J., Alperovich, M., Mentzer, S.J., Konerding, M.A., Huang, S., Ingber, D.E., Orgill, D.P.: Tensile forces stimulate vascular remodeling and epidermal cell proliferation in living skin. Ann. Surg. 246(5), 896–902 (2007)
28. Pilcher, B.K., Wang, M., Qin, X.J., Parks, W.C., Senior, R.M., Welgus, H.G.: Role of matrix metalloproteinases and their inhibition in cutaneous wound healing and allergic contact hypersensitivity. Ann. N. Y. Acad. Sci. 878, 12–24 (1999)
29. Riordan, C., Budny, P., Regan, P.: Pregnancy as an autologous tissue expander for closure of an abdominal-wall defect. Br. J. Plast. Surg. 56(1), 64–66 (2003)
30. Saxena, V., Hwang, C.W., Huang, S., Eichbaum, Q., Ingber, D., Orgill, D.P.: Vacuum-assisted closure: microdeformations of wounds and cell proliferation. Plast. Reconstr. Surg. 114(5), 1086–1096 (2004) discussion 1097-8
31. Saxena, V., Orgill, D., Kohane, I.: A set of genes previously implicated in the hypoxia response might be an important modulator in the rat ear tissue response to mechanical stretch. BMC Genomics 8, 430 (2007)
32. Scherer, S.S., Pietramaggiori, G., Mathews, J.C., Prsa, M.J., Huang, S., Orgill, D.P.: The mechanism of action of the vacuum-assisted closure device. Plast. Reconstr. Surg. 122(3), 786–797 (2008)
33. Silver, F.H., Siperko, L.M., Seehra, G.P.: Mechanobiology of force transduction in dermal tissue. Skin Res. Technol. 9(1), 3–23 (2003) (review)
34. Stockbridge, L.L., French, A.S.: Stretch-activated cation channels in human fibroblasts. Biophys. J. 54(1), 187–190 (1988)
35. Stolberg, S., McCloskey, K.E.: Can shear stress direct stem cell fate? Biotechnol. Prog. 25(1), 10–19 (2009)
36. Wang, N., Butler, J.P., Ingber, D.E.: Mechanotransduction across the cell surface and through the cytoskeleton. Science 260(5111), 1124–1127 (1993)
37. Wu, Z., Wong, K., Glogauer, M., Ellen, R.P., McCulloch, C.A.: Regulation of stretch-activated intracellular calcium transients by actin filaments. Biochem. Biophys. Res. Commun. 261(2), 419–425 (1999)
38. Zegarska, B., Lelinska, A., Tyrakowski, T.: Clinical and experimental aspects of cutaneous neurogenic inflammation. Pharmacol. Rep. 58(1), 13–21 (2006)
39. Zheng, Z., Lamotte, R.H., Grigg, P.: Comparison of responses to tensile and compressive stimuli in C-mechanosensitive nociceptors in rat hairy skin. Somatosens Mot. Res. 19(2), 109–113 (2002)