Hepatotoxicity of nintedanib in patients with idiopathic pulmonary fibrosis: A single-center experience

Respiratory Investigation

Volumn 55, Issue 1, 2017, Pages 51-54

  Ikeda, Satoshi ^a   Sekine, Akimasa ^a   Baba, Tomohisa ^a   Yamakawa, Hideaki ^a   Morita, Masato ^a   Kitamura, Hideya ^a   Ogura, Takashi ^a  

^a Kanagawa Prefectural Cardiovascular and Respiratory Diseases Center Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; NINTEDANIB; INDOLE DERIVATIVE;

AGED; ARTICLE; BODY MASS; BODY SURFACE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE REDUCTION; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; FIBROSING ALVEOLITIS; FORCED VITAL CAPACITY; HUMAN; JAPAN; LIVER TOXICITY; MALE; RETROSPECTIVE STUDY; CHEMICAL AND DRUG INDUCED LIVER INJURY; IDIOPATHIC PULMONARY FIBROSIS; INCIDENCE;

AGED; CHEMICAL AND DRUG INDUCED LIVER INJURY; FEMALE; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; INCIDENCE; INDOLES; MALE;

EID: 84994512323     PISSN: 22125345     EISSN: 22125353     Source Type: Journal    
DOI: 10.1016/j.resinv.2016.08.003     Document Type: Article

References (4)

1. [1] Raghu, G., Collard, H.R., Egan, J.J., et al. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med 183 (2011), 788–824.
2. [2] Common Terminology Criteria for Adverse Events (CTCAE) ver.4.0. 〈 http://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm#ctc_40〉 2016 [accessed 03.01.16].
3. [3] Okamoto, I., Miyazaki, M., Takeda, M., et al. Tolerability of nintedanib (BIBF 1120) in combination with docetaxel: a phase 1 study in Japanese patients with previously treated non-small-cell lung cancer. J Thorac Oncol 10:2 (2015), 346–352.
4. [4] Pharmaceuticals and Medical Devices Agency [Internet], Japan: [The examination report of nintedanib-ethanesulfonate]. Available from: 〈 http://www.pmda.go.jp/PmdaSearch/iyakuDetail/GeneralList/3999039M1〉 [in Japanese] [cited 03.07.15].