Genetic and Environmental Determinants of Otitis Media in an Indigenous Filipino Population

Otolaryngology - Head and Neck Surgery (United States)

Volumn 155, Issue 5, 2016, Pages 856-862

  Santos Cortez, Regie Lyn P ^a   Reyes Quintos, Ma Rina T ^b,c   Tantoco, Ma Leah C ^b,c   Abbe, Izoduwa ^a   Llanes, Erasmo Gonzalo D V ^b,c   Ajami, Nadim J ^a   Hutchinson, Diane S ^a   Petrosino, Joseph F ^a   Padilla, Carmencita D ^b,c,d   Villarta, Romeo L ^b,c   Gloria Cruz, Teresa Luisa ^b,c   Chan, Abner L ^b,c   Cutiongco De La Paz, Eva Maria ^b,c,d   Chiong, Charlotte M ^b,c   Leal, Suzanne M ^a   Abes, Generoso T ^b,c  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF THE PHILIPPINES MANILA   (Philippines)

^c UNIVERSITY OF THE PHILIPPINES MANILA   (Philippines)

^d UNIVERSITY OF THE PHILIPPINES   (Philippines)

Author keywords

A2ML1; indigenous population; microbiome; middle ear; otitis media; Philippines

Indexed keywords

DNA; RNA 16S; TOBACCO SMOKE; A2ML1 PROTEIN, HUMAN; ALPHA 2 MACROGLOBULIN;

ACUTE OTITIS MEDIA; ADOLESCENT; ADULT; ARTICLE; BACTEROIDES; BODY MASS; BREAST FEEDING; CHILD; CHRONIC OTITIS MEDIA; CORYNEBACTERIUM; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE PREDISPOSITION; DNA SEQUENCE; EARDRUM PERFORATION; ENVIRONMENTAL FACTOR; FAMILY HISTORY; FEMALE; FILIPINO (PEOPLE); FUSOBACTERIUM; GENETIC RISK; GENOTYPE; HAEMOPHILUS; HEIGHT; HUMAN; INDIGENOUS PEOPLE; MAJOR CLINICAL STUDY; MALE; MIDDLE EAR; PORPHYROMONAS; PREVALENCE; RNA SEQUENCE; SMOKING; SWIMMING; WEIGHT; ADVERSE EFFECTS; ENVIRONMENTAL EXPOSURE; GENETIC PREDISPOSITION; GENETICS; MICROBIOLOGY; MICROFLORA; OTITIS MEDIA; OTOSCOPY; PHILIPPINES; PRESCHOOL CHILD; RISK FACTOR;

ADOLESCENT; ADULT; ALPHA-MACROGLOBULINS; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; ENVIRONMENTAL EXPOSURE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MICROBIOTA; OTITIS MEDIA; OTOSCOPY; PHILIPPINES; PREVALENCE; RISK FACTORS;

EID: 84994344811     PISSN: 01945998     EISSN: 10976817     Source Type: Journal    
DOI: 10.1177/0194599816661703     Document Type: Article

References (19)

1. Gidengil C, Mangione-Smith R, Bailey LC, et al. Using Medicaid and CHIP claims data to support pediatric quality measurement: lessons from 3 centers of excellence in measure development. Acad Pediatr. 2014; 14: S76-S81.
2. Casey JR, Pichichero ME., Payment analysis of two diagnosis and management approaches of acute otitis media. Clin Pediatr (Phila). 2014; 53: 865-873.
3. Vaz LE, Kleinman KP, Raebel MA, et al. Recent trends in outpatient antibiotic use in children. Pediatrics. 2014; 133: 375-385.
4. Monasta L, Ronfani L, Marchetti F, et al. Burden of disease caused by otitis media: systematic review and global estimates. PLoS One. 2012; 7: e36226.
5. Jensen RG, Koch A, Homøe P., The risk of hearing loss in a population with a high prevalence of chronic suppurative otitis media. Int J Pediatr Otorhinolaryngol. 2013; 77: 1530-1535.
6. Jervis-Bardy J, Sanchez L, Carney AS., Otitis media in Indigenous Australian children: review of epidemiology and risk factors. J Laryngol Otol. 2014; 128 (suppl 1): S16-S27.
7. Li MG, Hotez PJ, Vrabec JT, Donovan DT., Is chronic suppurative otitis media a neglected tropical disease? PLoS Negl Trop Dis. 2015; 9: e0003485.
8. Leach AJ, Wigger C, Andrews R, Chatfield M, Smith-Vaughan H, Morris PS., Otitis media in children vaccinated during consecutive 7-valent or 10-valent pneumococcal conjugate vaccination schedules. BMC Pediatr. 2014; 14: 200.
9. Jacoby P, Carville KS, Hall G, et al. Crowding and other strong predictors of upper respiratory tract carriage of otitis media-related bacteria in Australian Aboriginal and non-Aboriginal children. Pediatr Infect Dis J. 2011; 30: 480-485.
10. Santos-Cortez RLP, Chiong CM, Reyes-Quintos MRT, et al. Rare A2ML1 variants confer susceptibility to otitis media. Nat Genet. 2015; 47: 917-920.
11. Reyes-Quintos MRT, Santos-Cortez RLP, Tantoco MLC, et al. Otoscopic and audiologic findings in an Ati community in Boracay. Philipp J Otolaryngol Head Neck Surg. 2007; 22: 19-21.
12. Santos-Cortez RLP, Ajami NJ, Reyes-Quintos MRT, et al. Carriage of an A2ML1 duplication variant that confers susceptibility to otitis media influences the middle ear microbiome. In: Abstracts of the 39th Annual Midwinter Meeting of the Association for Research in Otolaryngology. http://aro2016mwm.conferencespot.org/abstract-book-1.2856633. Published 2016. Accessed February 17, 2016.
13. R Development Core Team. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2011. http://www.R-project.org.
14. Wu L, Ge G, Zhu G, Gong S, Li S, Wan J., Diversity and composition of the bacterial community of Poyang Lake (China) as determined by 16S rRNA gene sequence analysis. World J Microbiol Biotechnol. 2012; 28: 233-244.
15. Poetker DM, Lindstrom DR, Edmiston CE, Krepel CJ, Link TR, Kerschner JE., Microbiology of middle ear effusions from 292 patients undergoing tympanostomy tube placement for middle ear disease. Int J Pediatr Otorhinolaryngol. 2005; 69: 799-804.
16. Rossau R, Kersters K, Falsen E, et al. Oligella, a new genus including Oligella urethralis comb nov (formerly Moraxella urethralis) and Oligella ureolytica sp nov (formerly CDC Group IVe): relationship to Taylorella equigenitalis and related taxa. Int J Syst Bacteriol. 1987; 37: 198-210.
17. Leach AJ, Wigger C, Hare K, et al. Reduced middle ear infection with non-typeable Haemophilus influenzae, but not Streptococcus pneumoniae, after transition to 10-valent pneumococcal non-typeable H influenzae protein D conjugate vaccine. BMC Pediatr. 2015; 15: 162.
18. Brook I., The role of anaerobic bacteria in chronic suppurative otitis media in children: implications for medical therapy. Anaerobe. 2008; 14: 297-300.
19. del Rosario R, Chiong CM, Chan AL, Yap EC, Jamir JC, Abes GT,. Microbial flora in chronic otitis media: value of ear aspirate culture studies. Philipp J Otolaryngol Head Neck Surg. 1990: 58-66.