Distinct subtypes of microparticle-containing immune complexes are associated with disease activity, damage, and carotid intima-media thickness in systemic lupus erythematosus

Journal of Rheumatology

Volumn 43, Issue 11, 2016, Pages 2019-2025

  Fortin, Paul R ^a   Cloutier, Nathalie ^a   Bissonnette, Vincent ^b   Aghdassi, Ellie ^c   Eder, Lihi ^d   Simonyan, David ^b   Laflamme, Nathalie ^b   Boilard, Eric ^a  

^a University Laval   (Canada)

^b LAVAL UNIVERSITY   (Canada)

^c TORONTO WESTERN HOSPITAL   (Canada)

^d WOMEN S COLLEGE HOSPITAL   (Canada)

Author keywords

AUTOANTIGENS; IMMUNE COMPLEXES; MICROPARTICLES; PLATELETS; SLE

Indexed keywords

ANTIMALARIAL AGENT; FIBRINOGEN RECEPTOR; IMMUNOGLOBULIN G; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHATIDYLSERINE; PREDNISONE;

ADULT; ARTERIAL WALL THICKNESS; ARTICLE; BLOOD SAMPLING; BLOOD VESSEL INJURY; BODY MASS; CAROTID ARTERY INJURY; CHOLESTEROL BLOOD LEVEL; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE COURSE; DRUG USE; ECHOGRAPHY; ETHNICITY; FEMALE; FLOW CYTOMETRY; HUMAN; MAJOR CLINICAL STUDY; MEMBRANE MICROPARTICLE; MUSCULOSKELETAL DISEASE ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SLEDAI; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC LUPUS INTERNATIONAL COLLABORATING CLINICS AMERICAN COLLEGE OF RHEUMATOLOGY DAMAGE INDEX; ATHEROSCLEROTIC PLAQUE; CAROTID ARTERY; DIAGNOSTIC IMAGING; IMMUNOLOGY; MALE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX;

ADULT; CAROTID ARTERIES; CAROTID INTIMA-MEDIA THICKNESS; CELL-DERIVED MICROPARTICLES; FEMALE; HUMANS; IMMUNOGLOBULIN G; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; PLAQUE, ATHEROSCLEROTIC; SEVERITY OF ILLNESS INDEX; ULTRASONOGRAPHY;

EID: 84994252978     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.160050     Document Type: Article

References (30)

1. Buzas EI, György B, Nagy G, Falus A, Gay S. Emerging role of extracellular vesicles in inflammatory diseases. Nat Rev Rheumatol 2014;10:356-64.
2. Morel O, Jesel L, Freyssinet JM, Toti F. Cellular mechanisms underlying the formation of circulating microparticles. Arterioscler Thromb Vasc Biol 2011;31:15-26.
3. Owens AP 3rd, Mackman N. Microparticles in hemostasis and thrombosis. Circ Res 2011;108:1284-97.
4. Dasgupta SK, Abdel-Monem H, Niravath P, Le A, Bellera RV, Langlois K, et al. Lactadherin and clearance of platelet-derived microvesicles. Blood 2009;113:1332-9.
5. Dasgupta SK, Le A, Chavakis T, Rumbaut RE, Thiagarajan P. Developmental endothelial locus-1 (Del-1) mediates clearance of platelet microparticles by the endothelium. Circulation 2012;125:1664-72.
6. Happonen KE, Tran S, Mörgelin M, Prince R, Calzavarini S, Angelillo-Scherrer A, et al. e Gas6-Axl protein interaction mediates endothelial uptake of platelet microparticles. J Biol Chem 2016;291:10586-601.
7. Arraud N, Gounou C, Linares R, Brisson AR. A simple flow cytometry method improves the detection of phosphatidylserine-exposing extracellular vesicles. J Thromb Haemost 2015;13:237-47.
8. Arraud N, Linares R, Tan S, Gounou C, Pasquet JM, Mornet S, et al. Extracellular vesicles from blood plasma: determination of their morphology, size, phenotype and concentration. J Thromb Haemost 2014;12:614-27.
9. Cloutier N, Tan S, Boudreau LH, Cramb C, Subbaiah R, Lahey L, et al. The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes. EMBO Mol Med 2013;5:235-49.
10. Nielsen CT, Østergaard O, Stener L, Iversen LV, Truedsson L, Gullstrand B, et al. Increased IgG on cell-derived plasma microparticles in systemic lupus erythematosus is associated with autoantibodies and complement activation. Arthritis Rheum 2012;64:1227-36.
11. Pisetsky DS, Ullal AJ, Gauley J, Ning TC. Microparticles as mediators and biomarkers of rheumatic disease. Rheumatology 2012;51:1737-46.
12. Ullal AJ, Reich CF 3rd, Clowse M, Criscione-Schreiber LG, Tochacek M, Monestier M, et al. Microparticles as antigenic targets of antibodies to DNA and nucleosomes in systemic lupus erythematosus. J Autoimmun 2011;36:173-80.
13. Wirestam L, Schierbeck H, Skogh T, Gunnarsson I, Ottosson L, Erlandsson-Harris H, et al. Antibodies against High Mobility Group Box protein-1 (HMGB1) versus other anti-nuclear antibody fine-specificities and disease activity in systemic lupus erythematosus. Arthritis Res Ther 2015;17:338.
14. Vogel S, Bodenstein R, Chen Q, Feil S, Feil R, Rheinlaender J, et al. Platelet-derived HMGB1 is a critical mediator of thrombosis. J Clin Invest 2015;125:4638-54.
15. Boilard E, Blanco P, Nigrovic PA. Platelets: active players in the pathogenesis of arthritis and SLE. Nat Rev Rheumatol 2012; 8:534-42.
16. Boudreau LH, Duchez AC, Cloutier N, Soulet D, Martin N, Bollinger J, et al. Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation. Blood 2014;124:2173-83.
17. Duffau P, Seneschal J, Nicco C, Richez C, Lazaro E, Douchet I, et al. Platelet CD154 potentiates interferon-alpha secretion by plasmacytoid dendritic cells in systemic lupus erythematosus. Sci Transl Med 2010;2:47ra63.
18. Sellam J, Proulle V, Jungel A, Ittah M, Miceli Richard C, Gottenberg JE, et al. Increased levels of circulating microparticles in primary Sjogren's syndrome, systemic lupus erythematosus and rheumatoid arthritis and relation with disease activity. Arthritis Res Ther 2009;11:R156.
19. Rousseau M, Belleannee C, Duchez AC, Cloutier N, Levesque T, Jacques F, et al. Detection and quantification of microparticles from different cellular lineages using flow cytometry. Evaluation of the impact of secreted phospholipase A2 on microparticle assessment. PLoS One 2015;10:e0116812.
20. Gladman DD, Ibañez D, Urowitz MB. Systemic lupus erythematosus disease activity index 2000. J Rheumatol 2002;29:288-91.
21. Gladman D, Ginzler E, Goldsmith C, Fortin P, Liang M, Urowitz M, et al. The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index for systemic lupus erythematosus. Arthritis Rheum 1996;39:363-9.
22. Lonn EM, Yusuf S, Doris CI, Sabine MJ, Dzavik V, Hutchison K, et al. Study design and baseline characteristics of the study to evaluate carotid ultrasound changes in patients treated with ramipril and vitamin E: SECURE. Am J Cardiol 1996;78:914-9.
23. Wright SA, O'Prey FM, McHenry MT, Leahey WJ, Devine AB, Duffy EM, et al. A randomised interventional trial of omega-3-polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosus. Ann Rheum Dis 2008;67:841-8.
24. Lonn E, Yusuf S, Hoogwerf B, Pogue J, Yi Q, Zinman B, et al; HOPE Study; MICRO-HOPE Study. Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy. Diabetes Care 2002;25:1919-27.
25. Spence JD. Ultrasound measurement of carotid plaque as a surrogate outcome for coronary artery disease. Am J Cardiol 2002;89:10B-5B.
26. Barnett PA, Spence JD, Manuck SB, Jennings JR. Psychological stress and the progression of carotid artery disease. J Hypertens 1997;15:49-55.
27. Parker B, Al-Husain A, Pemberton P, Yates AP, Ho P, Gorodkin R, et al. Suppression of inflammation reduces endothelial microparticles in active systemic lupus erythematosus. Ann Rheum Dis 2014;73:1144-50.
28. Zhang W, Dang S, Wang J, Nardi MA, Zan H, Casali P, et al. Specific cross-reaction of anti-dsDNA antibody with platelet integrin GPIIIa49-66. Autoimmunity 2010;43:682-9.
29. Beardsley DS. Platelet autoantigens: identification and characterization using immunoblotting. Blut 1989;59:47-51.
30. Nielsen CT, Rasmussen NS, Heegaard NH, Jacobsen S. Kill the messenger: targeting of cell-derived microparticles in lupus nephritis. Autoimmun Rev 2016;15:719-25.