A Coccidioides posadasii CPS1 deletion mutant is avirulent and protects mice from lethal infection

Infection and Immunity

Volumn 84, Issue 10, 2016, Pages 3007-3016

  Narra, Hema P ^a,d   Shubitz, Lisa F ^a,b   Mandel, M Alejandra ^a,b   Trinh, Hien T ^a,b   Griffin, Kurt ^c,e   Buntzman, Adam S ^c   Frelinger, Jeffrey A ^b,c   Galgiani, John N ^b,c   Orbach, Marc J ^a,b  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^d University of Texas Medical Branch School of Medicine   (United States)

^e UNIVERSITY OF SOUTH DAKOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRULENCE FACTOR; FUNGAL PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COCCIDIOIDES; COCCIDIOIDES POSADASII; COCCIDIOIDOMYCOSIS; CONTROLLED STUDY; CPS1 GENE; DELETION MUTANT; FEMALE; FUNGAL GENE; FUNGAL VIRULENCE; GENETIC TRANSCRIPTION; IN VITRO STUDY; INFECTION RESISTANCE; LETHALITY; METABOLIC REGULATION; MOUSE; MYCELIUM; NONHUMAN; NUCLEOTIDE SEQUENCE; ONYGENALES; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; SPOROGENESIS; SURVIVAL; VACCINATION; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; DISEASE MODEL; GENE DELETION; GENETICS; NONOBESE DIABETIC MOUSE; PHYSIOLOGY; PROCEDURES; VIRULENCE;

ANIMALS; COCCIDIOIDES; COCCIDIOIDOMYCOSIS; DISEASE MODELS, ANIMAL; FEMALE; FUNGAL PROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED NOD; SEQUENCE DELETION; VACCINATION; VIRULENCE; VIRULENCE FACTORS;

EID: 84994234368     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00633-16     Document Type: Article

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