Downregulated expression of miR-142-3p in macrophages contributes to increased IL-6 levels in aged mice

Molecular Immunology

Volumn 80, Issue , 2016, Pages 11-16

  Liu, Yin ^a   Song, Xiaoqi ^a   Meng, Shu ^a   Jiang, Minghong ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

Aging; IL 6; Macrophage; miR 142 3p

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; HISTONE; HISTONE DEACETYLASE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MICRORNA; MICRORNA 142 3P; POLYINOSINIC POLYCYTIDYLIC ACID; TRICHOSTATIN A; UNCLASSIFIED DRUG; INTERLEUKIN-6, MOUSE; MIRN142 MICRORNA, MOUSE;

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DEACETYLATION; GENE EXPRESSION; GENETIC ASSOCIATION; HISTONE MODIFICATION; IMMUNE RESPONSE; INFLAMMATION; INNATE IMMUNITY; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; DOWN REGULATION; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; MACROPHAGE; REAL TIME POLYMERASE CHAIN REACTION;

AGING; ANIMALS; DOWN-REGULATION; GENE EXPRESSION REGULATION; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED BALB C; MICRORNAS; POLY I-C; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84994059856     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2016.10.009     Document Type: Article

References (29)

1. Aung, H.T., Schroder, K., Himes, S.R., Brion, K., van Zuylen, W., Trieu, A., Suzuki, H., Hayashizaki, Y., Hume, D.A., Sweet, M.J., et al. LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression. FASEB J. 20 (2006), 1315–1327.
2. Bala, S., Marcos, M., Kodys, K., Csak, T., Catalano, D., Mandrekar, P., Szabo, G., Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor {alpha} (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease. J. Biol. Chem. 286 (2011), 1436–1444.
3. Bartel, D.P., MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116 (2004), 281–297.
4. Bode, K.A., Schroder, K., Hume, D.A., Ravasi, T., Heeg, K., Sweet, M.J., Dalpke, A.H., Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. Immunology 122 (2007), 596–606.
5. Busby, J., Caranasos, G.J., Immune function, autoimmunity, and selective immunoprophylaxis in the aged. Med. Clin. North Am. 69 (1985), 465–474.
6. Cheng, Y., Kuang, W., Hao, Y., Zhang, D., Lei, M., Du, L., Jiao, H., Zhang, X., Wang, F., Downregulation of miR-27a* and miR-532-5p and upregulation of miR-146a and miR-155 in LPS-induced RAW264.7 macrophage cells. Inflammation 35 (2012), 1308–1313.
7. Feng, J., Li, A., Deng, J., Yang, Y., Dang, L., Ye, Y., Li, Y., Zhang, W., miR-21 attenuates lipopolysaccharide-induced lipid accumulation and inflammatory response: potential role in cerebrovascular disease. Lipids Health Dis., 13, 2014, 27.
8. Fordham, J.B., Naqvi, A.R., Nares, S., Regulation of miR-24, miR-30b, and miR-142-3p during macrophage and dendritic cell differentiation potentiates innate immunity. J. Leukocyte Biol. 98 (2015), 195–207.
9. Franceschi, C., Bonafe, M., Valensin, S., Olivieri, F., De Luca, M., Ottaviani, E., De Benedictis, G., Inflamm-aging: an evolutionary perspective on immunosenescence. Ann. N. Y. Acad. Sci. 908 (2000), 244–254.
10. Gomez, C.R., Hirano, S., Cutro, B.T., Birjandi, S., Baila, H., Nomellini, V., Kovacs, E.J., Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure. Crit. Care Med. 35 (2007), 246–251.
11. Gomez, C.R., Nomellini, V., Baila, H., Oshima, K., Kovacs, E.J., Comparison of the effects of aging and IL-6 on the hepatic inflammatory response in two models of systemic injury: scald injury versus i.p LPS administration. Shock 31 (2009), 178–184.
12. Han, S.B., Lee, J.K., Anti-inflammatory effect of Trichostatin-A on murine bone marrow-derived macrophages. Arch. Pharm. Res. 32 (2009), 613–624.
13. Jiang, M., Xiang, Y., Wang, D., Gao, J., Liu, D., Liu, Y., Liu, S., Zheng, D., Dysregulated expression of miR-146a contributes to age-related dysfunction of macrophages. Aging Cell 11 (2012), 29–40.
14. Liu, G., Friggeri, A., Yang, Y., Park, Y.J., Tsuruta, Y., Abraham, E., miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses. Proc. Natl. Acad. Sci. U. S. A. 106 (2009), 15819–15824.
15. Liu, X., Zhan, Z., Li, D., Xu, L., Ma, F., Zhang, P., Yao, H., Cao, X., Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat. Immunol. 12 (2011), 416–424.
16. Livak, K.J., Schmittgen, T.D., Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25 (2001), 402–408.
17. Naqvi, A.R., Fordham, J.B., Nares, S., miR-24, miR-30b, and miR-142-3p regulate phagocytosis in myeloid inflammatory cells. J. Immunol. 194 (2015), 1916–1927.
18. O'Donnell, K.A., Wentzel, E.A., Zeller, K.I., Dang, C.V., Mendell, J.T., c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435 (2005), 839–843.
19. Obernosterer, G., Leuschner, P.J., Alenius, M., Martinez, J., Post-transcriptional regulation of microRNA expression. RNA 12 (2006), 1161–1167.
20. Pae, M., Meydani, S.N., Wu, D., The role of nutrition in enhancing immunity in aging. Aging Dis. 3 (2012), 91–129.
21. Plackett, T.P., Boehmer, E.D., Faunce, D.E., Kovacs, E.J., Aging and innate immune cells. J. Leukocyte Biol. 76 (2004), 291–299.
22. Roger, T., Lugrin, J., Le Roy, D., Goy, G., Mombelli, M., Koessler, T., Ding, X.C., Chanson, A.L., Reymond, M.K., Miconnet, I., et al. Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection. Blood 117 (2011), 1205–1217.
23. Schulte, L.N., Westermann, A.J., Vogel, J., Differential activation and functional specialization of miR-146 and miR-155 in innate immune sensing. Nucleic Acids Res. 41 (2013), 542–553.
24. Sun, Y., Varambally, S., Maher, C.A., Cao, Q., Chockley, P., Toubai, T., Malter, C., Nieves, E., Tawara, I., Wang, Y., et al. Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality. Blood 117 (2011), 6172–6183.
25. Thulin, P., Wei, T., Werngren, O., Cheung, L., Fisher, R.M., Grander, D., Corcoran, M., Ehrenborg, E., MicroRNA-9 regulates the expression of peroxisome proliferator-activated receptor delta in human monocytes during the inflammatory response. Int. J. Mol. Med. 31 (2013), 1003–1010.
26. Toki, S., Goleniewska, K., Reiss, S., Zhou, W., Newcomb, D.C., Bloodworth, M.H., Stier, M.T., Boyd, K.L., Polosukhin, V.V., Subramaniam, S., et al. The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activation. Thorax 71 (2016), 633–645.
27. Turnbull, I.R., Clark, A.T., Stromberg, P.E., Dixon, D.J., Woolsey, C.A., Davis, C.G., Hotchkiss, R.S., Buchman, T.G., Coopersmith, C.M., Effects of aging on the immunopathologic response to sepsis. Crit. Care Med. 37 (2009), 1018–1023.
28. Wu, W., He, C., Liu, C., Cao, A.T., Xue, X., Evans-Marin, H.L., Sun, M., Fang, L., Yao, S., Pinchuk, I.V., et al. miR-10a inhibits dendritic cell activation and Th1/Th17 cell immune responses in IBD. Gut 64 (2015), 1755–1764.
29. Zhao, Y., Samal, E., Srivastava, D., Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature 436 (2005), 214–220.