A Bead-Based Proximity Assay for BRD4 Ligand Discovery

Current protocols in chemical biology

Volumn 7, Issue 4, 2015, Pages 263-278

  Roberts, Justin M ^a   Bradner, James E ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

AlphaScreen; BRD4; bromodomain; high throughput screening; JQ1; protein protein interaction

Indexed keywords

(+)-JQ1 COMPOUND; AZEPINE DERIVATIVE; BIOTIN; BRD4 PROTEIN, HUMAN; LIGAND; MOLECULAR PROBE; NUCLEAR PROTEIN; PROTEIN BINDING; TRANSCRIPTION FACTOR; TRIAZOLE DERIVATIVE;

CHEMISTRY; HIGH THROUGHPUT SCREENING; HUMAN; IC50; METABOLISM; MOLECULAR PROBE; PROTEIN DOMAIN;

AZEPINES; BIOTIN; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MOLECULAR PROBES; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; TRANSCRIPTION FACTORS; TRIAZOLES;

EID: 84994050174     PISSN: None     EISSN: 21604762     Source Type: Journal    
DOI: 10.1002/9780470559277.ch150024     Document Type: Article

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