Mouse lysine catabolism to aminoadipate occurs primarily through the saccharopine pathway; implications for pyridoxine dependent epilepsy (PDE)

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1863, Issue 1, 2017, Pages 121-128

  Pena, Izabella Agostinho ^a,b   Marques, Lygia Azevedo ^a   Laranjeira, Ângelo B A ^a   Yunes, José A ^a   Eberlin, Marcos N ^a   MacKenzie, Alex ^b   Arruda, Paulo ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

Author keywords

Aminoadipate semialdehyde synthase; Lysine catabolism; Pipecolate; Pyridoxine dependent epilepsy; Saccharopine

Indexed keywords

AMINOADIPIC ACID; LYSINE; PIPECOLIC ACID; SACCHAROPINE DEHYDROGENASE; 2 AMINOADIPIC ACID; ALLYSINE; DELTA-1-PIPERIDINE-6-CARBOXYLIC ACID; PICOLINIC ACID DERIVATIVE; PYRIDOXAL 5 PHOSPHATE; SACCHAROPINE;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BRAIN LEVEL; CATABOLISM; COMPARATIVE STUDY; DEAMINATION; EPILEPSY; EPILEPTOGENESIS; FEMALE; LIQUID CHROMATOGRAPHY; LIVER LEVEL; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PYRIDOXINE DEPENDENT EPILEPSY; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; METABOLISM;

2-AMINOADIPIC ACID; ANIMALS; EPILEPSY; FEMALE; LYSINE; METABOLIC NETWORKS AND PATHWAYS; MICE; MICE, INBRED C57BL; PICOLINIC ACIDS; PYRIDOXAL PHOSPHATE;

EID: 84993990158     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2016.09.006     Document Type: Article

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