Chemical identification of botanical components using liquid chromatography/mass spectrometry

Therapeutic Innovation & Regulatory Science

Volumn 32, Issue 2, 1998, Pages 471-485

  Kerns, Edward H ^a   Volk, Kevin J ^a   Whitney, Jeffrey L ^a   Rourick, Robyn A ^a   Lee, Mike S ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Botanical; Database; Identification; LC MS; TAXOL

Indexed keywords

EID: 84993704987     PISSN: 21684790     EISSN: None     Source Type: Journal    
DOI: 10.1177/009286159803200220     Document Type: Article

References (36)

1. Johnson JV Yost RA Tandem mass spectrometry for trace analysis. Anal Chem. 1985; 57: 758A.
2. Busch KL Glish GL McLuckey SA Mass Spectrometry/Mass Spectrometry: Techniques and Applications of Tandem Mass Spectrometry. New York: VCH Publishers; 1988.
3. Lee MS Yost RA Perchalski RJ Tandem mass spectrometry and drug metabolism. In: Annual Reports in Medicinal Chemistry. Bailey DM, ed. New York: Academic Press Inc., 1986: Vol. 21, pp. 313–321.
4. Lee MS Yost RA Rapid identification of drug metabolites and tandem mass spectrometry. Biomed Env Mass Spectrom. 1988; 15: 193–204.
5. Volk KJ Klohr SE Rourick RA Kerns EH Lee MS Profiling impurities and degradants of butorphanol tartrate using liquid chromatography/mass spectrometry and liquid chromatography/tandem mass spectrometry substructural techniques. J Pharm Biomed Anal. 1996; 14: 1663.
6. Rourick RA Volk KJ Klohr SE Spears T Kerns EH Lee MS Predictive strategy for the rapid structure elucidation of drug degradants. J Pharm Biomed Anal. 1996; 14: 1743.
7. Lee MS Hook DJ Kerns EH Volk KJ Rosenberg IE Rapid screening of fermentation broths for flavones using tandem mass spectrometry. Biol Mass Spectrom. 1993; 22: 84.
8. Ranasinghe A Sweatlock JD Cooks RG A rapid screening method for artemisinin and its congeners using MS/MS: search for new analogues in Artemisia Annua. J Nat Prod. 1993; 56: 552.
9. Hoke SH II Wood JM Cooks RG Li XH Chang C. Rapid screening for taxanes by tandem mass spectrometry. Anal Chem. 1992; 64: 2113.
10. McClure TD Schram K Reimer ML The mass spectrometry of taxol. J Am Soc Spectrom. 1992; 3: 672.
11. Blay PKS Thibault P Thiberge N Kiecken B Leburn A Mercure C. Analysis of taxol and related taxanes from Taxus canadensis using liquid chromatography combined with mass spectrometry or tandem mass spectrometry. J Rapid Commun Mass Spectrom. 1993; 7: 626.
12. Auriola SOK Lepisto A Naaranlahti T Lapinjoki SP Determination of taxol by high-performance liquid chromatography-thermospray mass spectrometry. J Chrom. 1992; 594: 153.
13. Bitsch F Ma W Macdonald F Neider M Shackleton CH Analysis of taxol and related diterpenoids from cell cultures by liquid chromatography-electrospray mass spectrometry. J Chrom. 1993; 615: 273.
14. Bitsch F Shackelton CHL Ma W Park G Nieder M. Taxoid side-chain structure determination by electrospray ionization tandem mass spectrometry. J Rapid Commun Mass Spectrom. 1993; 7: 891.
15. Kerns EH Volk KJ Hill SE Lee MS Profiling taxanes in Taxus extracts using LC/MS and LC/MS/MS techniques. J Nat Prod. 1994; 57: 1391.
16. Kerns EH Volk KJ Hill SE Lee MS Profiling new taxanes using LC/MS profiling and LC/MS/MS substructural analysis techniques. J Rapid Commun Mass Spectrom. 1995; 9: 1539.
17. Volk KJ Hill SE Kerns EH Lee MS Profiling degradants of paclitaxel using liquid chromatography-mass spectrometry and liquid chromatographytandem mass spectrometry substructural techniques. Chromatography B. 1997; 696: 99.
18. Hook DJ Yacobucci JJ O'Connor S Lee MS Kerns E Krishnan B Matson J Hesler G. Identification of the inhibitory activity of carbazomycins B and C against 5-lipoxygenase, a new activity for these compounds. J Antibiot. 1990; 43: 1347–1348.
19. Miketova P Schram KH Whitney JL Kerns EH Valcic S Timmermann BN Volk KJ Mass spectrometry of components in green tea. J Nat Prod. 1998.
20. Lee MS Klohr SE Kerns EH Volk KJ Leet JE Schroeder DR Rosenberg IE The coordinated use of tandem mass spectrometry and high resolution mass spectrometry for the structure elucidation of the kedarcidin chromophore. Biol Mass Spectrom. 1998.
21. Gu Z Zhou D Wu J Shi G Zeng L McLaughlin JL Screening for annonaceous acetogenins in bioactive plant extracts by liquid chromatography/mass spectrometry. J Nat Prod. 1997; 60: 242.
22. Nawwar MAM Marzouk MS Nigge W Linscheid M. High-performance liquid chromatographic/electrospray ionization mass spectrometric screening for polyphenolic compounds of Epilobium hirsutum–The structure of the unique ellagitannin epilobamide-A. J Mass Spectrom. 1997; 32: 645.
23. Ackerman BL Regg BT Colombo L Stella S Coutant JE Rapid analysis of antibiotic-containing mixtures from fermentation broths by using liquid chromatography-electrospray ionization-mass spectrometry and matrix-assisted laser desorption ionization-time-of-flight-mass spectrometry. J Am Soc Mass Spectrom. 1996; 7: 1227.
24. Suffness M Cordeil GA Antitumor alkaloids. In: The Alkaloids. Chemistry and Pharmacology. 1985; 25: 3.
25. Schiff PB Fant J Horwitz SB Promotion of microtubule assembly in vitro by taxol. Nature. 1979; 277: 665.
26. Parness J Kingston DGI Powell RG Harracksingh C Horwitz SB Structure-activity study of cytotoxicity and microtubule assembly in vitro by taxol and related taxanes. Biochem Biophys Res Commun. 1982; 105: 1082.
27. Wani MC Taylor HL Wall ME Coggon P McPhail AT Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc. 1971; 93: 2325.
28. Miller RW A brief survey of taxus alkaloids and other taxane derivatives. J Nat Prod. 1980; 43: 425.
29. McLaughlin JL Miller RW Powell RG Smith Jr., CR. 19-Hydroxybaccatin III. 10-deacetylcephalo-mannine, and 10-deacetyltaxol: New antitumor taxanes from Taxus wallichiana. J Nat Prod. 1981; 44: 312.
30. Senilh V Blechert S Colin M Guénard D Picot F Potier P Varenne P. New analogs of taxol extracts from Taxus baccata. J Nat Prod. 1984; 47: 131.
31. Blechert S. Taxus alkaloids. The Alkaloids. Chemistry and Pharmacology. 1990; 39: 195.
32. Chen SH Combs CM Hill SE Farina V Doyle TW The photochemistry of taxol: Synthesis of a novel pentacyclic taxol isomer. Tet Letters. 1992; 33: 7679.
33. Kingston DGI The chemistry of taxol. Pharmac Ther. 1991; 52: 1.
34. de Marcano Delia Casa DP Halsall TG Structures of some taxol diterpenoids, baccatins-III, -IV, -VI, and -VII and 1-dehydroxybaccatin-IV, possessing an oxetan ring. J Chem Soc, Chem Commun. 1975; 9: 365.
35. Miller RW Powell RG Smith Jr., CR. Antileukemic alkaloids from Taxus wallichiana zucc. J Org Chem. 1981; 46: 1469.
36. Barboni L Gariboldi P Torrengiani E Appendino G Gabetta B Zini G Bombardelli E. The chemistry and occurrence of taxane derivatives. Part V. Taxanes from the needles of Taxus wallichiana. Phytochemistry. 1993; 33: 145.