Use of antibiotics in childhood and risk of Type 1 diabetes: a population-based case–control study

Diabetic Medicine

Volumn 34, Issue 2, 2017, Pages 272-277

  Mikkelsen, K H ^a,b   Knop, F K ^a,c   Vilsboll T ^a   Frost, M ^d   Hallas, J ^d   Pottegard A ^d  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Capital Region   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT;

ADOLESCENT; ARTICLE; ATOPIC DERMATITIS; CHILD; CHILD HOSPITALIZATION; CHILDHOOD DISEASE; CONTROLLED STUDY; DANISH CITIZEN; DENMARK; DRUG USE; FEMALE; HOSPITAL ADMISSION; HUMAN; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; NEWBORN; POLYURIA; POPULATION BASED CASE CONTROL STUDY; PRESCRIPTION; RISK FACTOR; URINARY TRACT INFECTION; CASE CONTROL STUDY; ODDS RATIO; PRESCHOOL CHILD; STATISTICAL MODEL;

ADOLESCENT; ANTI-BACTERIAL AGENTS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DENMARK; DIABETES MELLITUS, TYPE 1; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; LOGISTIC MODELS; MALE; ODDS RATIO; RISK FACTORS;

EID: 84992473192     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/dme.13262     Document Type: Article

References (30)

1. Atkinson MA, Eisenbarth GS, Michels AW. Type 1 diabetes. Lancet 2014; 383: 69–82.
2. Gale EA. The rise of childhood type 1 diabetes in the 20th century. Diabetes 2002; 51: 3353–3361.
3. Kostic AD, Gevers D, Siljander H, Vatanen T, Hyötyläinen T, Hämäläinen A-M et al. The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes. Cell Host Microbe 2015; 17: 260–73.
4. Knip M, Siljander H. The role of the intestinal microbiota in type 1 diabetes mellitus. Nat Rev Endocrinol 2016; 12: 154–167.
5. Wen L, Ley RE, Volchkov PY, Stranges PB, Avanesyan L, Stonebraker AC et al. Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature 2008; 455: 1109–1113.
6. Markle JGM, Frank DN, Mortin-Toth S, Robertson CE, Feazel LM, Rolle-Kampczyk U et al. Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science 2013; 339: 1084–1088.
7. Burrows MP, Volchkov P, Kobayashi KS, Chervonsky AV. Microbiota regulates type 1 diabetes through Toll-like receptors. Proc Natl Acad Sci. 2015; 112: 9973–9977.
8. Raymond F, Ouameur AA, Déraspe M, Iqbal N, Gingras H, Dridi B et al. The initial state of the human gut microbiome determines its reshaping by antibiotics. ISME J 2016; 10: 707–720.
9. Korpela K, Salonen A, Virta LJ, Kekkonen RA, Forslund K, Bork P et al. Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children. Nat Commun 2016; 7: 10410.
10. Brown K, Godovannyi A, Ma C, Zhang Y, Ahmadi-Vand Z, Dai C et al. Prolonged antibiotic treatment induces a diabetogenic intestinal microbiome that accelerates diabetes in NOD mice. ISME J 2016; 10: 321–32.
11. Candon S, Perez-Arroyo A, Marquet C, Valette F, Foray A-P, Pelletier B et al. Antibiotics in early life alter the gut microbiome and increase disease incidence in a spontaneous mouse model of autoimmune insulin-dependent diabetes. PloS One 2015; 10: e0125448.
12. Hu Y, Peng J, Tai N, Hu C, Zhang X, Wong FS et al. Maternal antibiotic treatment protects offspring from diabetes development in nonobese diabetic mice by generation of tolerogenic APCs. J Immunol 2015; 195: 4176–4184.
13. Hansen CHF, Krych L, Nielsen DS, Vogensen FK, Hansen LH, Sørensen SJ et al. Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse. Diabetologia 2012; 55: 2285–94.
14. Schmidt M, Schmidt SAJ, Sandegaard JL, Ehrenstein V, Pedersen L, Sørensen HT. The Danish National Patient Registry: a review of content, data quality, and research potential. Clin Epidemiol 2015; 7: 449–490.
15. Kildemoes HW, Sørensen HT, Hallas J. The Danish National Prescription Registry. Scand J Public Health 2011; 39: 38–41.
16. Pedersen CB. The Danish Civil Registration System. Scand J Public Health 2011; 39: 22–25.
17. Schmidt M, Pedersen L, Sørensen HT. The Danish Civil Registration System as a tool in epidemiology. Eur J Epidemiol. 2014; 29: 541–549.
18. Smans LCCJ, Souverein PC, Leufkens HGM, Hoepelman AIM, Zelissen PMJ. Increased use of antimicrobial agents and hospital admission for infections in patients with primary adrenal insufficiency: a cohort study. Eur J Endocrinol 2013; 168: 609–614.
19. Thomsen SF, Duffy DL, Kyvik KO, Skytthe A, Backer V. Relationship between type 1 diabetes and atopic diseases in a twin population: Type 1 diabetes and atopic diseases in twins. Allergy 2011; 66: 645–647.
20. Pottegård A, Broe A, Aabenhus R, Bjerrum L, Hallas J, Damkier P. Use of Antibiotics in Children: A Danish Nationwide Drug Utilization Study. Pediatr Infect Dis J 2015; 34: e16–22.
21. Mikkelsen KH, Knop FK, Frost M, Hallas J, Pottegård A. Use of antibiotics and risk of type 2 diabetes: a population-based case-control study. J Clin Endocrinol Metab 2015; 100: 3633–3640.
22. Thygesen LC, Daasnes C, Thaulow I, Brønnum-Hansen H. Introduction to Danish (nationwide) registers on health and social issues: structure, access, legislation, and archiving. Scand J Public Health 2011; 39: 12–16.
23. Patel KA, Oram RA, Flanagan SE, De Franco E, Colclough K, Shepherd M et al. Type 1 diabetes genetic risk score: a novel tool to discriminate monogenic and type 1 diabetes. Diabetes 2016; 65: 2094–2099.
24. Simonsen JR, Harjutsalo V, Järvinen A, Kirveskari J, Forsblom C, Groop P-H et al. Bacterial infections in patients with type 1 diabetes: a 14-year follow-up study. BMJ Open Diabetes Res Care 2015; 3: e000067.
25. Nobel YR, Cox LM, Kirigin FF, Bokulich NA, Yamanishi S, Teitler I et al. Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment. Nat Commun 2015; 6: 7486.
26. Hviid A, Svanström H. Antibiotic use and type 1 diabetes in childhood. Am J Epidemiol 2009; 169: 1079–1084.
27. Boursi B, Mamtani R, Haynes K, Yang Y-X. The effect of past antibiotic exposure on diabetes risk. Eur J Endocrinol 2015; 172: 639–648.
28. Palmer C, Bik EM, DiGiulio DB, Relman DA, Brown PO. Development of the human infant intestinal microbiota. PLoS Biol 2007; 5: e177.
29. Kronborg H, Foverskov E, Væth M. Breastfeeding and introduction of complementary food in Danish infants. Scand J Public Health 2015; 43: 138–145.
30. Bergström A, Skov TH, Bahl MI, Roager HM, Christensen LB, Ejlerskov KT et al. Establishment of Intestinal Microbiota during Early Life: a Longitudinal, Explorative Study of a Large Cohort of Danish Infants. Appl Environ Microbiol 2014; 80: 2889–2900.