A proof-of-concept study with the tyrosine kinase inhibitor nilotinib in spondyloarthritis

Journal of Translational Medicine

Volumn 14, Issue 1, 2016, Pages

  Paramarta, Jacqueline E ^a   Turina, Maureen C ^a   Noordenbos, Troy ^a   Heijda, Tanja F ^a   Blijdorp, Iris C ^a   Yeremenko, Nataliya ^a   Baeten, Dominique ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Mast cells; Nilotinib; Randomized controlled trial; Spondyloarthritis; Tyrosine kinase inhibitor

Indexed keywords

C REACTIVE PROTEIN; CALGRANULIN; CD163 ANTIGEN; CD68 ANTIGEN; INTERLEUKIN 6; NILOTINIB; PLACEBO; 4-METHYL-N-(3-(4-METHYLIMIDAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL)-3-((4-PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO)BENZAMIDE; BIOLOGICAL MARKER; MESSENGER RNA; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE;

ACNE; ADULT; ANOREXIA; ARTICLE; BLOOD SAMPLING; BREAST DISEASE; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CLINICAL EVALUATION; COMMON COLD; CONSTIPATION; CONTROLLED STUDY; COUGHING; DEPRESSION; DISEASE ACTIVITY; DOUBLE BLIND PROCEDURE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SAFETY; FATIGUE; FEMALE; FLANK PAIN; GASTROENTERITIS; HAIR LOSS; HEADACHE; HEART PALPITATION; HOT FLUSH; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOMODULATION; MACROPHAGE; MALAISE; MALE; MAST CELL; MYALGIA; NAUSEA; PERIPHERAL EDEMA; RANDOMIZED CONTROLLED TRIAL; RASH; SINUSITIS; SPONDYLARTHRITIS; STOMACH PAIN; SYNOVIUM; TREATMENT DURATION; WEIGHT REDUCTION; BLOOD; COMPLICATION; DRUG EFFECTS; GENETICS; INFLAMMATION; METABOLISM; MIDDLE AGED; PATHOLOGY;

ADULT; BIOMARKERS; FEMALE; HUMANS; IMMUNOMODULATION; INFLAMMATION; MALE; MIDDLE AGED; PLACEBOS; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RNA, MESSENGER; SPONDYLARTHRITIS; SYNOVIAL MEMBRANE;

EID: 84992453285     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-016-1050-2     Document Type: Article

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