Identifying Inherited and Acquired Genetic Factors Involved in Poor Stem Cell Mobilization and Donor-Derived Malignancy

Biology of Blood and Marrow Transplantation

Volumn 22, Issue 11, 2016, Pages 2100-2103

  Rojek, Katarzyna ^a   Nickels, Eric ^a   Neistadt, Barbara ^a   Marquez, Rafael ^a   Wickrema, Amittha ^a   Artz, Andrew ^a   van Besien, Koen ^a,d   Larson, Richard A ^a   Lee, Ming K ^b   Segal, Jeremy P ^a   King, Mary Claire ^b   Walsh, Tom ^b   Shimamura, Akiko ^c,e   Keel, Sioban B ^c   Churpek, Jane E ^a   Godley, Lucy A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d NEW YORK PRESBYTERIAN HOSPITAL   (United States)

^e BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Clonal hematopoiesis of indeterminate potential; Donor derived leukemia; TET2 mutation

Indexed keywords

GENOMIC DNA; GRANULOCYTE COLONY STIMULATING FACTOR; PROTEIN; TET2 PROTEIN; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; ONCOPROTEIN; TET2 PROTEIN, HUMAN;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD DONOR; CLONAL EVOLUTION; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENE MUTATION; GENETIC IDENTIFICATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEREDITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MEGALOCYTOSIS; MIDDLE AGED; MYELOID LEUKEMIA; NEXT GENERATION SEQUENCING; STEM CELL MOBILIZATION; THROMBOCYTOPENIA; DNA MUTATIONAL ANALYSIS; GENETIC PREDISPOSITION; GENETICS; MYELODYSPLASTIC SYNDROME; NEOPLASM; PEDIGREE; STANDARDS; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; BLOOD DONORS; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; NEOPLASMS; PEDIGREE; PROTO-ONCOGENE PROTEINS; YOUNG ADULT;

EID: 84992390512     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2016.08.002     Document Type: Article

References (8)

1. 1 Churpek, J.E., Nickels, E., Marquez, R., et al. Identifying familial myelodysplastic/acute leukemia predisposition syndromes through hematopoietic stem cell transplantation donors with thrombocytopenia. Blood 120 (2012), 5247–5249.
2. 2 Fogarty, P.F., Yamaguchi, H., Wiestner, A., et al. Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA. Lancet 362 (2003), 1628–1630.
3. 3 Zhang, M.Y., Keel, S.B., Walsh, T., et al. Genomic analysis of bone marrow failure and myelodysplastic syndromes reveals phenotypic and diagnostic complexity. Haematologica 100 (2015), 42–48.
4. 4 Vulliamy, T.J., Walne, A., Baskaradas, A., Mason, P.J., Marrone, A., Dokal, I., Mutations in the reverse transcriptase component of telomerase (TERT) in patients with bone marrow failure. Blood Cells Mol Dis 34 (2005), 257–263.
5. 5 Genovese, G., Kahler, A.K., Handsaker, R.E., et al. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med 371 (2014), 2477–2487.
6. 6 Jaiswal, S., Fontanillas, P., Flannick, J., et al. Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med 371 (2014), 2488–2498.
7. 7 Olnes, M.J., Poon, A., Miranda, S.J., et al. Effects of granulocyte-colony-stimulating factor on Monosomy 7 aneuploidy in healthy hematopoietic stem cell and granulocyte donors. Transfusion 52 (2012), 537–541.
8. 8 Wiseman, D.H., Donor cell leukemia: a review. Biol Blood Marrow Transplant 17 (2011), 771–789.