Clusters of ineffective efforts during mechanical ventilation: impact on outcome

Intensive Care Medicine

Volumn 43, Issue 2, 2017, Pages 184-191

  Vaporidi, Katerina ^a   Babalis, Dimitris ^a   Chytas, Achilleas ^b,c   Lilitsis, Emmanuel ^a   Kondili, Eumorfia ^a   Amargianitakis, Vasilis ^a   Chouvarda, Ioanna ^b,c   Maglaveras, Nicos ^b,c   Georgopoulos, Dimitris ^a  

^a UNIVERSITY HOSPITAL OF HERAKLION   (Greece)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^c INFORMATION TECHNOLOGIES INSTITUTE   (Greece)

Author keywords

Assisted modes; Mortality; Patient ventilator interaction

Indexed keywords

ADULT; ARTICLE; ARTIFICIAL VENTILATION; ASSISTED VENTILATION; BREATHING; CRITICALLY ILL PATIENT; HUMAN; MAJOR CLINICAL STUDY; MATHEMATICAL MODEL; MORTALITY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PATIENT CODING; PRESSURE SUPPORT VENTILATION; PROPORTIONAL ASSIST VENTILATION; PROSPECTIVE STUDY; RECORDING; RISK; SELECTION BIAS; TREATMENT OUTCOME; AGED; APACHE; COMORBIDITY; CRITICAL ILLNESS; FEMALE; INTENSIVE CARE UNIT; MALE; MIDDLE AGED; NONPARAMETRIC TEST; PHYSIOLOGIC MONITORING; PROCEDURES; RESPIRATORY INSUFFICIENCY; TIME FACTOR; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; APACHE; COMORBIDITY; CRITICAL ILLNESS; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; MONITORING, PHYSIOLOGIC; PROSPECTIVE STUDIES; RESPIRATORY INSUFFICIENCY; STATISTICS, NONPARAMETRIC; TIME FACTORS; TREATMENT OUTCOME;

EID: 84992223356     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-016-4593-z     Document Type: Article

References (25)

1. Thille AW, Rodriguez P, Cabello B, Lellouche F, Brochard L (2006) Patient-ventilator asynchrony during assisted mechanical ventilation. Intensive Care Med 32:1515–1522
2. de Wit M, Pedram S, Best AM, Epstein SK (2009) Observational study of patient-ventilator asynchrony and relationship to sedation level. J Crit Care 24:74–80
3. Thille AW, Cabello B, Galia F, Lyazidi A, Brochard L (2008) Reduction of patient-ventilator asynchrony by reducing tidal volume during pressure-support ventilation. Intensive Care Med 34:1477–1486
4. Fanfulla F, Delmastro M, Berardinelli A, Lupo ND, Nava S (2005) Effects of different ventilator settings on sleep and inspiratory effort in patients with neuromuscular disease. Am J Respir Crit Care Med 172:619–624
5. Nava S, Bruschi C, Fracchia C, Braschi A, Rubini F (1997) Patient-ventilator interaction and inspiratory effort during pressure support ventilation in patients with different pathologies. Eur Respir J 10:177–183
6. Purro A, Appendini L, De Gaetano A, Gudjonsdottir M, Donner CF, Rossi A (2000) Physiologic determinants of ventilator dependence in long-term mechanically ventilated patients. Am J Respir Crit Care Med 161:1115–1123
7. de Wit M, Miller KB, Green DA, Ostman HE, Gennings C, Epstein SK (2009) Ineffective triggering predicts increased duration of mechanical ventilation. Crit Care Med 37:2740–2745
8. Blanch L, Villagra A, Sales B, Montanya J, Lucangelo U, Lujan M, Garcia-Esquirol O, Chacon E, Estruga A, Oliva JC, Hernandez-Abadia A, Albaiceta GM, Fernandez-Mondejar E, Fernandez R, Lopez-Aguilar J, Villar J, Murias G, Kacmarek RM (2015) Asynchronies during mechanical ventilation are associated with mortality. Intensive Care Med 41:633–641
9. Georgopoulos D (2012) Ineffective efforts during mechanical ventilation: the brain wants, the machine declines. Intensive Care Med 38:738–740
10. Babalis D, Lilitsis E, Akoumianaki E, Prinianakis G, Georgopoulos D, Kondili E (2011) Incidence of ineffective efforts in mechanically ventilated critically ill patients. Intensive Care Med 37:S1 (Abstract 0005)
11. Younes M, Brochard L, Grasso S, Kun J, Mancebo J, Ranieri M, Richard JC, Younes H (2007) A method for monitoring and improving patient: ventilator interaction. Intensive Care Med 33:1337–1346
12. Kondili E, Alexopoulou C, Xirouchaki N, Vaporidi K, Georgopoulos D (2010) Estimation of inspiratory muscle pressure in critically ill patients. Intensive Care Med 36:648–655
13. Vitacca M, Bianchi L, Zanotti E, Vianello A, Barbano L, Porta R, Clini E (2004) Assessment of physiologic variables and subjective comfort under different levels of pressure support ventilation. Chest 126:851–859
14. Blanch L, Sales B, Montanya J, Lucangelo U, Garcia-Esquirol O, Villagra A, Chacon E, Estruga A, Borelli M, Burgueno MJ, Oliva JC, Fernandez R, Villar J, Kacmarek R, Murias G (2012) Validation of the better care® system to detect ineffective efforts during expiration in mechanically ventilated patients: a pilot study. Intensive Care Med 38:772–780
15. Antonelli M, Bonten M, Cecconi M, Chastre J, Citerio G, Conti G, Curtis JR, Hedenstierna G, Joannidis M, Macrae D, Maggiore SM, Mancebo J, Mebazaa A, Preiser JC, Rocco P, Timsit JF, Wernerman J, Zhang H (2013) Year in review in intensive care medicine 2012: III noninvasive ventilation, monitoring and patient-ventilator interactions, acute respiratory distress syndrome, sedation, paediatrics and miscellanea. Intensive Care Med 39:543–557
16. Simon PM, Zurob AS, Wies WM, Leiter JC, Hubmayr RD (1999) Entrainment of respiration in humans by periodic lung inflations. Effect of state and CO(2). Am J Respir Crit Care Med 160:950–960
17. Simon PM, Habel AM, Daubenspeck JA, Leiter JC (2000) Vagal feedback in the entrainment of respiration to mechanical ventilation in sleeping humans. J Appl Physiol 89:760–769
18. Akoumianaki E, Lyazidi A, Rey N, Matamis D, Perez-Martinez N, Giraud R, Mancebo J, Brochard L, Marie Richard JC (2013) Mechanical ventilation-induced reverse-triggered breaths: a frequently unrecognized form of neuromechanical coupling. Chest 143:927–938
19. Boles JM, Bion J, Connors A, Herridge M, Marsh B, Melot C, Pearl R, Silverman H, Stanchina M, Vieillard-Baron A, Welte T (2007) Weaning from mechanical ventilation. Eur Respir J 29:1033–1056
20. Hermans G, Van den Berghe G (2015) Clinical review: intensive care unit acquired weakness. Crit Care 19:274
21. Watchko JF, Johnson BD, Gosselin LE, Prakash YS, Sieck GC (1994) Age-related differences in diaphragm muscle injury after lengthening activations. J Appl Physiol 77:2125–2133
22. Gosselin LE, Burton H (2002) Impact of initial muscle length on force deficit following lengthening contractions in mammalian skeletal muscle. Muscle Nerve 25:822–827
23. Bosma K, Ferreyra G, Ambrogio C, Pasero D, Mirabella L, Braghiroli A, Appendini L, Mascia L, Ranieri VM (2007) Patient-ventilator interaction and sleep in mechanically ventilated patients: pressure support versus proportional assist ventilation. Crit Care Med 35:1048–1054
24. Georgopoulos D, Prinianakis G, Kondili E (2006) Bedside waveforms interpretation as a tool to identify patient-ventilator asynchronies. Intensive Care Med 32:34–47
25. Blackwood B, Burns KE, Cardwell CR, O’Halloran P (2014) Protocolized versus non-protocolized weaning for reducing the duration of mechanical ventilation in critically ill adult patients. Cochrane Database Syst Rev CD006904. doi:10.1002/14651858.CD006904.pub3