Post-exertion malaise in chronic fatigue syndrome: Symptoms and gene expression

Fatigue: Biomedicine, Health and Behavior

Volumn 1, Issue 4, 2013, Pages 190-209

  Meyer, Jacob D ^a,b   Light, Alan R ^c   Shukla, Sanjay K ^d   Clevidence, Derek ^e   Yale, Steven ^d   Stegner, Aaron J ^b   Cook, Dane B ^a,b  

^a WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d MARSHFIELD CLINIC   (United States)

^e Meriter Clinic   (United States)

Author keywords

chronic fatigue; exercise; genomics; metabolite; post exertion malaise; psychobiology

Indexed keywords

ADRENERGIC RECEPTOR; BETA ACTIN; GLUCOCORTICOID RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 6; TRANSCRIPTION FACTOR;

ADULT; ANAMNESIS; ARTICLE; CHRONIC FATIGUE SYNDROME; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DRUG SENSITIVITY; EXERCISE TEST; FEMALE; GENE EXPRESSION; HUMAN; INTERVIEW; MALAISE; MALE; MCGILL PAIN QUESTIONNAIRE; OXYGEN CONSUMPTION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; SINGLE NUCLEOTIDE POLYMORPHISM; VISUAL ANALOG SCALE;

EID: 84992064236     PISSN: 21641846     EISSN: 21641862     Source Type: Journal    
DOI: 10.1080/21641846.2013.838444     Document Type: Article

References (39)

1. Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International chronic fatigue syndrome study group. Ann Intern Med. 1994 Dec 15;121(12):953-959. doi: 10.7326/0003-4819-121-12-199412150-00009
2. Becker PD, McGregor N, Meirleir KD. A definition-based analysis of symptoms in a large cohort of patients with chronic fatigue syndrome. J Inter Med. 2001 Sep;250(3):234-240. doi: 10.1046/j.1365-2796.2001.00890.x
3. Bazelmans E, Bleijenberg G, van der Meer JW, Folgering H. Is physical deconditioning a perpetuating factor in chronic fatigue syndrome? A controlled study on maximal exercise performance and relations with fatigue, impairment and physical activity. Psychol Med. 2001 Jan;31(1):107-114. doi: 10.1017/S0033291799003189
4. Black CD, O'connor PJ, McCully KK. Increased daily physical activity and fatigue symptoms in chronic fatigue syndrome. Dyn Med. 2005 Mar 3;4(1):3. doi: 10.1186/1476-5918-4-3
5. Peterson PK, Sirr SA, Grammith FC, Schenck CH, Pheley AM, Hu S et al. Effects of mild exercise on cytokines and cerebral blood flow in chronic fatigue syndrome patients. Clin Diagn Lab Immunol. 1994 Mar;1(2):222-226.
6. Riley MS, O'Brien CJ, McCluskey DR, Bell NP, Nicholls DP. Aerobic work capacity in patients with chronic fatigue syndrome. BMJ. 1990 Oct 27;301(6758):953-956. doi: 10.1136/bmj.301.6758.953
7. VanNess JM, Snell CR, Stevens SR. Diminished cardiopulmonary capacity during post- exertional malaise. Journal of Chronic Fatigue Syndrome. 2007;14(2):77-85. doi: 10.1300/J092v14n02_07
8. Ohashi K, Yamamoto Y, Natelson BH. Activity rhythm degrades after strenuous exercise in chronic fatigue syndrome. Physiol Behav. 2002 Sep;77(1):39-44. doi: 10.1016/S0031-9384(02)00808-9
9. Yoshiuchi K, Cook DB, Ohashi K, Kumano H, Kuboki T, Yamamoto Y et al. A real-time assessment of the effect of exercise in chronic fatigue syndrome. Physiol Behav. 2007 Dec 5;92(5):963-968. doi: 10.1016/j.physbeh.2007.07.001
10. Cook DB, Nagelkirk PR, Peckerman A, Poluri A, Mores J, Natelson BH. Exercise and cognitive performance in chronic fatigue syndrome. Med Med Sci Sports Exerc. 2005 Sep;37(9):1460-1467. doi: 10.1249/01.mss.0000179921.48404.ef
11. LaManca JJ, Sisto SA, DeLuca J, Johnson SK, Lange G, Pareja J et al. Influence of exhaustive treadmill exercise on cognitive functioning in chronic fatigue syndrome. The Am J Med. 1998 Sep 28;105(3A):59S-65S. doi: 10.1016/S0002-9343(98)00171-5
12. Jammes Y, Steinberg JG, Delliaux S, Bregeon F. Chronic fatigue syndrome combines increased exercise-induced oxidative stress and reduced cytokine and Hsp responses. J Inter Med. 2009 Aug;266(2):196-206. doi: 10.1111/j.1365-2796.2009.02079.x
13. Nijs J, van Oosterwijck J, Meeus M, Lambrecht L, Metzger K, Fremont M et al. Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1beta. J Inter Med. 2010 Apr;267(4):418-435. doi: 10.1111/j.1365-2796.2009.02178.x
14. Natelson BH, Haghighi MH, Ponzio NM. Evidence for the presence of immune dysfunction in chronic fatigue syndrome. Clin Diagn Lab Immunol. 2002 Jul;9(4):747-752.
15. Light AR, White AT, Hughen RW, Light KC. Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects. The Journal of Pain: Official Journal of the American Pain Society. 2009 Oct;10(10):1099-1112. doi: 10.1016/j.jpain.2009.06.003
16. Light AR, Bateman L, Jo D, Hughen RW, VanHaitsma TA, White AT et al. Gene expression alterations at baseline and following moderate exercise in patients with chronic fatigue syndrome and fibromyalgia syndrome. J Inter Med. 2012 Jan;271(1):64-81. doi: 10.1111/j.1365-2796.2011.02405.x
17. Cook DB, Nagelkirk PR, Poluri A, Mores J, Natelson BH. The influence of aerobic fitness and fibromyalgia on cardiorespiratory and perceptual responses to exercise in patients with chronic fatigue syndrome. Arthritis Rheum. 2006 Oct;54(10):3351-3362. doi: 10.1002/art.22124
18. Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum. 1990 Feb;33(2):160-72.
19. Wagner D, Nisenbaum R, Heim C, Jones JF, Unger ER, Reeves WC. Psychometric properties of the CDC Symptom Inventory for assessment of chronic fatigue syndrome. Popul Health Metr. 2005 Jul 22;3:8. doi: 10.1186/1478-7954-3-8
20. Melzack R. The short-form McGill pain questionnaire. Pain. 1987 Aug;30(2):191-197. doi: 10.1016/0304-3959(87)91074-8
21. McNair DM, Lorr M, Droppleman LF. Profile of mood states: manual. San Diego, Calif. Educational and Industrial Testing Services (Edits); 1992.
22. O'Connor PJ. Mental energy: assessing the mood dimension. Nutr Rev. 2006;64:S7-S9. doi: 10.1111/j.1753-4887.2006.tb00256.x
23. Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992 Jun;30(6):473-483. doi: 10.1097/00005650-199206000-00002
24. Smets EM, Garssen B, Bonke B, Haes JC. The multidimensional fatigue inventory (MFI) psychometric qualities of an instrument to assess fatigue. J Psychosom Res. 1995;39(3):315-325. doi: 10.1016/0022-3999(94)00125-O
25. Borg G. Subjective aspects of physical and mental load. Ergonomics. 1978 Mar;21(3):215-220. doi: 10.1080/00140137808931715
26. Cook DB, O'Connor PJ, Eubanks SA, Smith JC, Lee M. Naturally occurring muscle pain during exercise: assessment and experimental evidence. Med Sci Sports Exerc. 1997 Aug;29(8):999-1012. doi: 10.1097/00005768-199708000-00004
27. Cohen J. Statistical power analysis for the behavioral sciences. 1st ed. New York and London: Academic Press; 1969.
28. Maes M, van Gastel A, Delmeire L, Kenis G, Bosmans E, Song C. Platelet alpha2- adrenoceptor density in humans: relationships to stress-induced anxiety, psychasthenic constitution, gender and stress-induced changes in the inflammatory response system. Psychol Med. 2002 Jul;32(5):919-928. doi: 10.1017/S0033291702005925
29. Martinez-Lavin M, Vidal M, Barbosa RE, Pineda C, Casanova JM, Nava A. Norepinephrine-evoked pain in fibromyalgia. A randomized pilot study. BMC Musculoskelet Disord. 2002;3:2. doi: 10.1186/1471-2474-3-2
30. Meeus M, Nijs J. Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome. Clin Rheumatol. 2007 Apr;26(4):465-473. doi: 10.1007/s10067-006-0433-9
31. Papadopoulos AS, Cleare AJ. Hypothalamic-pituitary-adrenal axis dysfunction in chronic fatigue syndrome. Nat Rev Endocrinol. 2012 Jan;8(1):22-32. doi: 10.1038/nrendo.2011.153
32. Tak LM, Cleare AJ, Ormel J, Manoharan A, Kok IC, Wessely S et al. Meta-analysis and meta-regression of hypothalamic-pituitary-adrenal axis activity in functional somatic disorders. Biol Psychol. 2011 May;87(2):183-194. doi: 10.1016/j.biopsycho.2011.02.002
33. Hayashi R, Wada H, Ito K, Adcock IM. Effects of glucocorticoids on gene transcription. Eur J Pharmacol. 2004 Oct;500(1-3):51-62. doi: 10.1016/j.ejphar.2004.07.011
34. Rajeevan MS, Smith AK, Dimulescu I, Unger ER, Vernon SD, Heim C et al. Glucocorticoid receptor polymorphisms and haplotypes associated with chronic fatigue syndrome. Genes Brain Behav. 2007 Mar;6(2):167-176. doi: 10.1111/j.1601-183X.2006.00244.x
35. Smith AK, White PD, Aslakson E, Vollmer-Conna U, Rajeevan MS. Polymorphisms in genes regulating the HPA axis associated with empirically delineated classes of unexplained chronic fatigue. Pharmacogenomics. 2006 Apr;7(3):387-394. doi: 10.2217/14622416.7.3.387
36. Goertzel BN, Pennachin C, Coelho L de S, Gurbaxani B, Maloney EM, Jones JF. Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes predict chronic fatigue syndrome. Pharmacogenomics. 2006 Apr;7(3):475-483. doi: 10.2217/14622416.7.3.475
37. Light K, White A, Tadler S, Jacob E, Light A. Genetics and gene expression involving stress and distress pathways in fibromyalgia with and without comorbid chronic fatigue syndrome. Pain Research and Treatment. 2012; Article ID 427869: 13.
38. van Ness JM, Stevens SR, Bateman L, Stiles TL, Snell CR. Postexertional malaise in women with chronic fatigue syndrome. J Womens Health (2002). 2010 Feb;19(2):239-244. doi: 10.1089/jwh.2009.1507
39. Sullivan PF, Fan C, Perou CM. Evaluating the comparability of gene expression in blood and brain. Am J Med Genet. 2006 Apr 5;141B(3):261-268. doi: 10.1002/ajmg.b.30272