A pH- and ionic strength-dependent conformational change in the neck region regulates DNGR-1 function in dendritic cells

EMBO Journal

Volumn 35, Issue 22, 2016, Pages 2484-2497

  Hanč, Pavel ^a   Schulz, Oliver ^a   Fischbach, Hanna ^a   Martin, Stephen R ^a   Kjær, Svend ^a   Reis e Sousa, Caetano ^a  

^a THE FRANCIS CRICK INSTITUTE   (United Kingdom)

Author keywords

C type lectin receptors; cross presentation; necrosis; protein structure

Indexed keywords

CASPASE 9; CELL RECEPTOR; CHIMERIC PROTEIN; CYSTEINE; DECTIN 1; DIMER; DISULFIDE; DNGR 1 RECEPTOR; DOXYCYCLINE; GLYCOSYLATED PROTEIN; ISOPROTEIN; LECTIN RECEPTOR; UNCLASSIFIED DRUG; CLEC9A PROTEIN, MOUSE; IMMUNOGLOBULIN RECEPTOR; LECTIN;

ARTICLE; CELL PH; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CROSS PRESENTATION; DELETION MUTANT; DENATURATION; DENDRITIC CELL; DIMERIZATION; DISULFIDE BOND; ELECTROPHORETIC MOBILITY; GLYCOSYLATION; HUMAN; IONIC STRENGTH; MOUSE; NECK; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; REDUCTION; WESTERN BLOTTING; ALLOSTERISM; ANIMAL; CHEMISTRY; DNA MUTATIONAL ANALYSIS; DRUG EFFECTS; GENETICS; METABOLISM; OSMOLARITY; PH; PROTEIN CONFORMATION;

ALLOSTERIC REGULATION; ANIMALS; DENDRITIC CELLS; DNA MUTATIONAL ANALYSIS; HYDROGEN-ION CONCENTRATION; LECTINS, C-TYPE; MICE; OSMOLAR CONCENTRATION; PROTEIN CONFORMATION; RECEPTORS, IMMUNOLOGIC;

EID: 84991669523     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201694695     Document Type: Article

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