Deep Sequencing of the T-cell Receptor Repertoire Demonstrates Polyclonal T-cell Infiltrates in Psoriasis

F1000Research

Volumn 4, Issue , 2015, Pages

  Harden, Jamie L ^a   Hamm, David ^b   Gulati, Nicholas ^a   Lowes, Michelle A ^c   Krueger, James G ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b ADAPTIVE BIOTECHNOLOGIES   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Polyclonal; Psoriasis; T cell; T cell receptor (TCR); TCR deep sequencing; T cells; T cells

Indexed keywords

EID: 84991649223     PISSN: 20461402     EISSN: 1759796X     Source Type: Journal    
DOI: 10.12688/f1000research.6756.1     Document Type: Article

References (14)

1. Cai Y Fleming C Yan J : New insights of T cells in the pathogenesis of psoriasis. Cell Mol Immunol. 2012;9(4):302-9. 22705915 10.1038/cmi.2012.15 4132586
2. Chang JC Smith LR Froning KJ : CD8 + T-cells in psoriatic lesions preferentially use T-cell receptors V beta 3 and/or V beta 13.1 genes. Ann N Y Acad Sci. 1995;756:370-81. 7645853 10.1111/j.1749-6632.1995.tb44541.x
3. Elbe A Foster CA Stingl G : T-cell receptor alpha beta and gamma delta T cells in rat and human skin--are they equivalent? Semin Immunol. 1996;8(6):341-9. 8961385 10.1006/smim.1996.0045
4. Harden J David H Gulati N : Dataset 1 in: Deep Sequencing of the T-cell Receptor Repertoire Demonstrates Polyclonal T-cell Infiltrates in Psoriasis. F1000Research. 2015. Data Source
5. Jordan CT Cao L Roberson ED : PSORS2 is due to mutations in CARD14. Am J Hum Genet. 2012;90(5):784-95. 22521418 10.1016/j.ajhg.2012.03.012 3376640
6. Lowes MA Suárez-Fariñas M Krueger JG : Immunology of psoriasis. Annu Rev Immunol. 2014;32:227-55. 24655295 10.1146/annurev-immunol-032713-120225 4229247
7. Marrakchi S Guigue P Renshaw BR : Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis. N Engl J Med. 2011;365(7):620-8. 21848462 10.1056/NEJMoa1013068
8. Menssen A Trommler P Vollmer S : Evidence for an antigen-specific cellular immune response in skin lesions of patients with psoriasis vulgaris. J Immunol. 1995;155(8):4078-83. 7561119
9. Perera GK Di Meglio P Nestle FO : Psoriasis. Annu Rev Pathol. 2012;7:385-422. 22054142 10.1146/annurev-pathol-011811-132448
10. Robins H : Immunosequencing: applications of immune repertoire deep sequencing. Curr Opin Immunol. 2013;25(5):646-52. 24140071 10.1016/j.coi.2013.09.017
11. Robins HS Campregher PV Srivastava SK : Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells. Blood. 2009;114(19):4099-107. 19706884 10.1182/blood-2009-04-217604 2774550
12. Sherwood AM Emerson RO Scherer D : Tumor-infiltrating lymphocytes in colorectal tumors display a diversity of T cell receptor sequences that differ from the T cells in adjacent mucosal tissue. Cancer Immunol Immunother. 2013;62(9):1453-61. 23771160 10.1007/s00262-013-1446-2
13. Vollmer S Menssen A Prinz JC : Dominant lesional T cell receptor rearrangements persist in relapsing psoriasis but are absent from nonlesional skin: evidence for a stable antigen-specific pathogenic T cell response in psoriasis vulgaris. J Invest Dermatol. 2001;117(5):1296-301. 11710947 10.1046/j.0022-202x.2001.01494.x
14. Zaba LC Cardinale I Gilleaudeau P : Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses. J Exp Med. 2007;204(13):3183-94. 18039949 10.1084/jem.20071094 2150965