SYMPLICITY HTN-Japan – First randomized controlled trial of catheter-based renal denervation in Asian patients

Circulation Journal

Volumn 79, Issue 6, 2015, Pages 1222-1229

  Kario, Kazuomi ^a   Ogawa, Hisao ^b   Okumura, Ken ^c,l   Okura, Takafumi ^d,d   Saito, Shigeru ^e   Ueno, Takafumi ^f   Haskin, Russel ^g   Negoita, Manuela ^h   Shimada, Kazuyuki ⁱ   Okuyama, Yuji ^j   Kimura, Takeshi ^k   Aonuma, Kazutaka ^m   Kobayashi, Yoshio ⁿ   Miura, Tetsuji ^o   Ichihara, Atsuhiro ^p   Hirooka, Yoshitaka ^q   Tanabe, Kengo ^r   Hasebe, Naoyuki ^s  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY HOSPITAL   (Japan)

^c HIROSAKI UNIVERSITY   (Japan)

^d EHIME UNIVERSITY HOSPITAL   (Japan)

^e SHONAN KAMAKURA GENERAL HOSPITAL   (Japan)

^f KURUME UNIVERSITY HOSPITAL   (Japan)

^g Medtronic Japan ^*  (Japan)

^h MEDTRONIC INC   (United States)

ⁱ New Oyama Municipal Hospital   (Japan)

^j OSAKA UNIVERSITY HOSPITAL   (Japan)

^k KYOTO UNIVERSITY HOSPITAL   (Japan)

^l HIROSAKI UNIVERSITY   (Japan)

^m UNIVERSITY OF TSUKUBA HOSPITAL   (Japan)

ⁿ CHIBA UNIVERSITY HOSPITAL   (Japan)

^o SAPPORO MEDICAL UNIVERSITY HOSPITAL   (Japan)

^p TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^q KYUSHU UNIVERSITY HOSPITAL   (Japan)

^r MITSUI MEMORIAL HOSPITAL   (Japan)

^s ASAHIKAWA MEDICAL COLLEGE   (Japan)

more..

Author keywords

Ambulatory blood pressure; Asia; Renal denervation; Resistant hypertension

Indexed keywords

ANTIHYPERTENSIVE AGENT; CREATININE; MINERALOCORTICOID ANTAGONIST;

ADULT; ARTICLE; BLOOD ANALYSIS; BLOOD PRESSURE MONITORING; CATHETERIZATION; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CLINICAL TRIAL; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; FOLLOW UP; GLOMERULUS FILTRATION RATE; HUMAN; HUMAN EXPERIMENT; JAPAN; KIDNEY DENERVATION; KIDNEY FUNCTION; MALE; MIDDLE AGED; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RESISTANT HYPERTENSION; STATISTICAL ANALYSIS; SYSTOLIC BLOOD PRESSURE; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CATHETER ABLATION; COMORBIDITY; HYPERTENSION; INNERVATION; KIDNEY ARTERY; METHODOLOGY; MULTICENTER STUDY; MULTIMODALITY CANCER THERAPY; PROCEDURES; SAMPLE SIZE; SYMPATHECTOMY;

AGED; ANTIHYPERTENSIVE AGENTS; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD PRESSURE MONITORING, AMBULATORY; CATHETER ABLATION; COMBINED MODALITY THERAPY; COMORBIDITY; FEMALE; HUMANS; HYPERTENSION; JAPAN; MALE; MIDDLE AGED; MINERALOCORTICOID RECEPTOR ANTAGONISTS; PROSPECTIVE STUDIES; RENAL ARTERY; RESEARCH DESIGN; SAMPLE SIZE; SYMPATHECTOMY; TREATMENT OUTCOME;

EID: 84991373055     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-15-0150     Document Type: Article

References (28)

1. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: Analysis of worldwide data. Lancet 2005; 365: 217 – 223.
2. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R, Prospective Studies Collaboration. Age-specific relevance of usual blood pressure to vascular mortality: A meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002; 360: 1903 – 1913.
3. Ogihara T, Kikuchi K, Matsuoka H, Fujita T, Higaki J, Horiuchi M, et al. The Japanese Society of Hypertension guidelines for the management of hypertension (JSH 2009). Hypertens Res 2009; 32: 3 – 107.
4. Miura K, Nagai M, Ohkubo T. Epidemiology of hypertension in Japan: Where are we now? Circ J 2013; 77: 2226 – 2231.
5. Perkovic V, Huxley R, Wu Y, Prabhakaran D, MacMahon S. The burden of blood pressure-related disease: A neglected priority for global health. Hypertension 2007; 50: 991 – 997.
6. Woodward M, Barzi F, Martiniuk A, Fang X, Gu DF, Imai Y, et al. Cohort profile: The Asia Pacific Cohort Studies Collaboration. Int J Epidemiol 2006; 35: 1412 – 1416.
7. Kario K. Proposal of a new strategy for ambulatory blood pressure profile-based management of resistant hypertension in the era of renal denervation. Hypertens Res 2013; 36: 478 – 484.
8. Daugherty SL, Powers JD, Magid DJ, Tavel HM, Masoudi FA, Margolis KL, et al. Incidence and prognosis of resistant hypertension in hypertensive patients. Circulation 2012; 125: 1635 – 1642.
9. de la Sierra A, Segura J, Banegas JR, Gorostidi M, de la Cruz JJ, Armario P, et al. Clinical features of 8295 patients with resistant hypertension classified on the basis of ambulatory blood pressure monitoring. Hypertension 2011; 57: 898 – 902.
10. Polimeni A, Curcio A, Indolfi C. Renal sympathetic denervation for treating resistant hypertension. Circ J 2013; 77: 857 – 863.
11. Esler M., Krum H, Schlaich M, Schmieder RE, Böhm M, Sobotka PA. Renal sympathetic denervation for treatment of drug-resistant hypertension: One-year results from the SYMPLICITY HTN-2 randomized, controlled trial. Circulation 2012; 126: 2976 – 2982.
12. Krum H, Schlaich MP, Böhm M, Mahfoud F, Rocha-Singh K, Katholi R, et al. Percutaneous renal denervation in patients with treatment-resistant hypertension: Final 3-year report of the SYMPLICITY HTN-1 study. Lancet 2014; 383: 622 – 629.
13. Mahfoud F, Ukena C, Schmieder RE, Cremers B, Rump LC, Vonend O, et al. Ambulatory blood pressure changes after renal sympathetic denervation in patients with resistant hypertension. Circulation 2013; 128: 132 – 140.
14. Hering D, Marusic P, Walton AS, Lambert EA, Krum H, Narkiewicz K, et al. Sustained sympathetic and blood pressure reduction 1 year after renal denervation in patients with resistant hypertension. Hypertension 2014; 64: 118 – 124.
15. Bhatt DL, Kandzari DE, O’Neill WW, D’Agostino R, Flack JM, Katzen BT, et al. A controlled trial of renal denervation for resistant hypertension. N Engl J Med 2014; 370: 1393 – 1401.
16. Bakris GL, Townsend RR, Liu M, Cohen SA, D’Agostino R, Flack JM, et al. Impact of renal denervation on 24-hour ambulatory blood pressure: Results from SYMPLICITY HTN-3. J Am Coll Cardiol 2014; 64: 1071 – 1078.
17. Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, et al. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis 2009; 53: 982 – 992.
18. Esler M.; for the SYMPLICITY HTN-2 Investigators. Renal sympathetic denervation in patients with treat-resistant hypertension (The SYMPLICITY HTN-2 Trial): A randomised controlled trial. Lancet 2010; 376: 1903 – 1909.
19. O’Brien E, Parati G, Stergiou G, Asmar R, Beilin L, Bilo G, et al; European Society of Hypertension Working Group on Blood Pressure Monitoring. European Society of Hypertension position paper on ambulatory blood pressure monitoring. J Hypertens 2013; 31: 1731 – 1768.
20. Böhm M, Schumacher H, Laufs U, Sleight P, Schmieder R, Unger T, et al. Effects of nonpersistence with medication on outcomes in high-risk patients with cardiovascular disease. Am Heart J 2013; 166: 306 – 314.e7, doi:10.1016/j.ahj.2013.04.016.
21. Kandzari D, Bhatt DL, Brar S, Devireddy CM, Esler M, Fahy M, et al. Predictors of blood pressure response in the SYMPLICITY HTN-3 trial. Eur Heart J 2015; 36: 219 – 227.
22. Wray DW, Supiano MA. Impact of aldosterone receptor blockade compared with thiazide therapy on sympathetic nervous system function in geriatric hypertension. Hypertension 2010; 55: 1217 – 1223.
23. DiBona GF, Esler M. Translational medicine: The antihypertensive effect of renal denervation. Am J Physiol 2010; 298: R245 – R253.
24. Ueshima H, Sekikawa A, Miura K, Turin TC, Takashima N, Kita Y, et al. Cardiovascular disease and risk factors in Asia: A selected review. Circulation 2008; 118: 2702 – 2709.
25. Ishikawa Y, Ishikawa J, Ishikawa S, Kajii E, Schwartz JE, Pickering TG, et al. Prehypertension and the risk for cardiovascular disease in the Japanese general population: The Jichi Medical School Cohort Study. J Hypertens 2010; 28: 1630 – 1637.
26. Stamler J. The INTERSALT study: Background, methods, findings, and implications. Am J Clin Nutr 1997; 65: 626S – 642S.
27. Katsuya T, Ishikawa K, Sugimoto K, Rakugi H, Ogihara T. Salt sensitivity of Japanese from the viewpoint of gene polymorphism. Hypertens Res 2003; 26: 521 – 525.
28. Kario K, Pickering TG, Umeda Y, Hoshide S, Hoshide Y, Morinari M, et al. Morning surge in blood pressure as a predictor of silent and clinical cerebrovascular disease in elderly hypertensives: A prospective study. Circulation 2003; 107: 1401 – 1406.