Tight control of disease activity fails to improve body composition or physical function in rheumatoid arthritis patients

Rheumatology (United Kingdom)

Volumn 55, Issue 10, 2016, Pages 1736-1745

  Lemmey, Andrew B ^a   Wilkinson, Thomas J ^a   Clayton, Rebecca J ^a,b   Sheikh, Fazal ^a,b   Whale, John ^a   Jones, Hope S J ^a   Ahmad, Yasmeen A ^a,b   Chitale, Sarang ^a,b   Jones, Jeremy G ^a,b   Maddison, Peter J ^a,b   O'Brien, Thomas D ^a,c  

^a BANGOR UNIVERSITY   (United Kingdom)

^b YSBYTY GWYNEDD   (United Kingdom)

^c LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

Author keywords

Body composition; Physical function; Rheumatoid arthritis; Rheumatoid cachexia; Treat to target

Indexed keywords

ANALGESIC AGENT; BIOLOGICAL PRODUCT; CORTICOSTEROID; DISEASE MODIFYING ANTIRHEUMATIC DRUG; HYDROXYCHLOROQUINE; LEFLUNOMIDE; METHOTREXATE; MYCOPHENOLATE MOFETIL; NONSTEROID ANTIINFLAMMATORY AGENT; SALAZOSULFAPYRIDINE; TACROLIMUS;

ADULT; APPENDICULAR SKELETON; ARTICLE; BODY COMPOSITION; CACHEXIA; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DAILY LIFE ACTIVITY; DAS28; DISEASE ACTIVITY; DUAL ENERGY X RAY ABSORPTIOMETRY; EXTENSOR MUSCLE; FAT MASS; FEMALE; FUNCTION TEST; FUNCTIONAL ASSESSMENT; GRIP STRENGTH; HUMAN; INFLAMMATION; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MUSCLE STRENGTH; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REMISSION; RHEUMATOID ARTHRITIS; SITTING; STANDING; TREAT TO TARGET; TREATMENT PLANNING; TRUNK; WALKING; ARTHRITIS, RHEUMATOID; CASE CONTROL STUDY; DISABLED PERSON; EXERCISE; HAND STRENGTH; HEALTH STATUS; PATHOPHYSIOLOGY; PHYSIOLOGY; SKELETAL MUSCLE; TREATMENT OUTCOME; WAIST CIRCUMFERENCE;

ACTIVITIES OF DAILY LIVING; ARTHRITIS, RHEUMATOID; BODY COMPOSITION; CACHEXIA; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; DISABLED PERSONS; EXERCISE; FEMALE; HAND STRENGTH; HEALTH STATUS; HUMANS; MALE; MIDDLE AGED; MUSCLE STRENGTH; MUSCLE, SKELETAL; TREATMENT OUTCOME; WAIST CIRCUMFERENCE;

EID: 84991063619     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/kew243     Document Type: Article

References (50)

1. Roubenoff R, Roubenoff R, Ward L et al. Rheumatoid cachexia: depletion of lean body mass in rheumatoid arthritis. Possible association with tumor necrosis factor. J Rheumatol 1992;19:1505-10.
2. Book C, Karlsson MK, Åkesson K, Jacobsson LT. Early rheumatoid arthritis and body composition. Rheumatology 2009;48:1128-32.
3. Marcora SM, Lemmey AB, Maddison PJ. Can progressive resistance training reverse cachexia in patients with rheumatoid arthritis? Results of a pilot study. J Rheumatol 2005;32:1031-9.
4. Matschke V, Murphy P, Lemmey AB et al. Skeletal muscle properties in rheumatoid arthritis patients. Med Sci Sports Exerc 2010;42:2149-55.
5. Toussirot E, Nguyen N, Dumoulin G et al. Relationship between growth hormone-IGF-I-IGFBP-3 axis and serum leptin levels with bone mass and body composition in patients with rheumatoid arthritis. Rheumatology 2005;44:120-5.
6. Baker JF, Long J, Ibrahim S, Leonard MB, Katz P. Are men at greater risk of lean mass deficits in rheumatoid arthritis? Arthritis Care Res 2015;67:112-9.
7. Elkan AC, Engvall IL, Tengstrand B et al. Malnutrition in women with rheumatoid arthritis is not revealed by clinical anthropometrical measurements or nutritional evaluation tools. Eur J Clin Nutr 2008;62:1239-47.
8. Elkan A-C, Engvall I-L, Cederholm T, Hafström I. Rheumatoid cachexia, central obesity and malnutrition in patients with low-active rheumatoid arthritis: feasibility of anthropometry, Mini Nutritional Assessment and body composition techniques. Eur J Nutr 2009;48:315-22.
9. Lemmey AB, Marcora SM, Chester K et al. Effects of high-intensity resistance training in patients with rheumatoid arthritis: a randomized controlled trial. Arthritis Care Res 2009;61:1726-34.
10. Lemmey AB, Williams SL, Marcora SM et al. Are the benefits of a high-intensity progressive resistance training program sustained in rheumatoid arthritis patients? A 3-year followup study. Arthritis Care Res 2012;64:71-5.
11. Marcora SM, Lemmey AB, Maddison PJ. Dietary treatment of rheumatoid cachexia with b-hydroxy-b-methylbutyrate, glutamine and arginine: a randomised controlled trial. Clin Nutr 2005;24:442-54.
12. Marcora SM, Chester KR, Mittal G et al. Randomized phase 2 trial of anti-tumor necrosis factor therapy for cachexia in patients with early rheumatoid arthritis. Am J Clin Nutr 2006;84:1463-72.
13. Munro R, Capell H. Prevalence of low body mass in rheumatoid arthritis: association with the acute phase response. Ann Rheum Dis 1997;56:326-9.
14. Roubenoff R, Roubenoff RA, Cannon J et al. Rheumatoid cachexia: cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation. J Clin Invest 1994;93:2379-86.
15. Summers G, Deighton C, Rennie M, Booth A. Rheumatoid cachexia: a clinical perspective. Rheumatology 2008;47:1124-31.
16. Stavropoulos-Kalinoglou A, Metsios GS, Panoulas VF et al. Underweight and obese states both associate with worse disease activity and physical function in patients with established rheumatoid arthritis. Clin Rheumatol 2009;28:439-44.
17. Giles JT, Allison M, Blumenthal RS et al. Abdominal adiposity in rheumatoid arthritis: association with cardiometabolic risk factors and disease characteristics. Arthritis Rheumatol 2010;62:3173-82.
18. Katz PP, Yazdany J, Trupin L et al. Sex differences in assessment of obesity in rheumatoid arthritis. Arthritis Care Res 2013;65:62-70.
19. Summers GD, Metsios GS, Stavropoulos-Kalinoglou A, Kitas GD. Rheumatoid cachexia and cardiovascular disease. Nat Rev Rheumatol 2010;6:445-51.
20. Baker JF, Von Feldt J, Mostoufi-Moab S et al. Deficits in muscle mass, muscle density, and modified associations with fat in rheumatoid arthritis. Arthritis Care Res 2014;66:1612-8.
21. Giles JT, Bartlett SJ, Andersen RE, Fontaine KR, Bathon JM. Association of body composition with disability in rheumatoid arthritis: impact of appendicular fat and lean tissue mass. Arthritis Rheum 2008;59:1407-15.
22. Lusa AL, Amigues I, Kramer HR et al. Indicators of walking speed in rheumatoid arthritis: relative influence of articular, psychosocial, and body composition characteristics. Arthritis Care Res 2015;67:21-31.
23. Smolen JS, Aletaha D, Bijlsma JW et al. Treating rheumatoid arthritis to target: recommendations of an international task force. Ann Rheum Dis 2010;69:631-7.
24. Smolen JS, Breedveld FC, Burmester GR et al. Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force. Ann Rheum Dis 2016;75:1-13.
25. Solomon DH, Bitton A, Katz JN et al. Review: treat to target in rheumatoid arthritis: fact, fiction, or hypothesis? Arthritis Rheum 2014;66:775-82.
26. Vermeer M, Kuper H, Moens H et al. Sustained beneficial effects of a protocolized treat-to-target strategy in very early rheumatoid arthritis: three-year results of the Dutch Rheumatoid Arthritis Monitoring remission induction cohort. Arthritis Care Res 2013;65:1219-26.
27. Walsmith J, Abad L, Kehayias J, Roubenoff R. Tumor necrosis factor-alpha production is associated with less body cell mass in women with rheumatoid arthritis. J Rheumatol 2004;31:23-9.
28. Singh JA, Furst DE, Bharat A et al. 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care Res 2012;64:625-39.
29. Chen YM, Chen HH, Hsieh CW et al. A close association of body cell mass loss with disease activity and disability in Chinese patients with rheumatoid arthritis. Clinics 2011;66:1217-22.
30. Matschke V, Murphy P, Lemmey AB, Maddison PJ, Thom JM, Muscle quality, architecture, and activation in cachectic patients with rheumatoid arthritis. J Rheumatol 2010;37:282-4.
31. Matschke V, Jones JG, Lemmey AB et al. Patellar tendon properties and lower limb function in rheumatoid arthritis and ankylosing spondylitis versus healthy controls: a cross-sectional study. ScientificWorldJournal 2013;2013:514743.
32. Seto Y, Inoue E, Shidara K et al. Functional disability can deteriorate despite suppression of disease activity in patients with rheumatoid arthritis: a large observational cohort study. Mod Rheumatol 2013;23:1179-85.
33. Sugihara T, Ishizaki T, Hosoya T et al. Structural and functional outcomes of a therapeutic strategy targeting low disease activity in patients with elderly-onset rheumatoid arthritis: a prospective cohort study (CRANE). Rheumatology 2015;54:798-807.
34. Sokka T, Kankainen A, Hannonen P. Scores for functional disability in patients with rheumatoid arthritis are correlated at higher levels with pain scores than with radiographic scores. Arthritis Rheum 2000;43:386-9.
35. Wolfe F. A reappraisal of HAQ disability in rheumatoid arthritis. Arthritis Rheum 2000;43:2751-61.
36. Van den Ende C, Breedveld F, Dijkmans B, Hazes J. The limited value of the Health Assessment Questionnaire as an outcome measure in short term exercise trials. J Rheumatol 1997;24:1972-7.
37. Aletaha D, Neogi T, Silman AJ et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010;62:2569-81.
38. Rikli RE, Jones CJ. Development and validation of criterion-referenced clinically relevant fitness standards for maintaining physical independence in later years. Gerontologist 2013;53:255-67.
39. Matschke V, Thom JM, Lemmey AB et al. Adverse changes in tendon-muscle physiology and physical function caused by an isolated acute rheumatoid knee effusion: a case study. Arthritis Care Res 2012;64:117-21.
40. Pincus T, Sokka T, Kautiainen H. Further development of a physical function scale on a multidimensional health assessment questionnaire for standard care of patients with rheumatic diseases. J Rheumatol 2005;32:1432-9.
41. Engvall I-L, Elkan A-C, Tengstrand B et al. Cachexia in rheumatoid arthritis is associated with inflammatory activity, physical disability, and low bioavailable insulin-like growth factor. Scand J Rheumatol 2008;37:321-8.
42. Giles JT, Ling SM, Ferrucci L et al. Abnormal body composition phenotypes in older rheumatoid arthritis patients: association with disease characteristics and pharmacotherapies. Arthritis Care Res 2008;59:807-15.
43. Dao H-H, Do QT, Sakamoto J. Abnormal body composition phenotypes in Vietnamese women with early rheumatoid arthritis. Rheumatology 2011;50:1250-8.
44. Book C, Karlsson M, Nilsson JÅ et al. Changes in body composition after 2 years with rheumatoid arthritis. Scand J Rheumatol 2011;40:95-100.
45. Pescatello LS; America College of Sports Medicine. ACSM's guidelines for exercise testing and prescription, 9th edn. Pescatello LS, Arena R, Riebe D, Thompson PD, eds. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins, 2014.
46. Malm K, Bergman S, Andersson M, Bremander A; BARFOT Study Group. Predictors of severe self-reported disability in RA in a long-term follow-up study. Disabil Rehabil 2015;37:686-91.
47. Pincus T, Castrejón I, Yazici Y. Documenting the value of care for rheumatoid arthritis, analogous to hypertension, diabetes, and hyperlipidemia: is control of individual patient self-report measures of global estimate and physical function more valuable than laboratory tests, radiographs, indices, or remission criteria? J Rheumatol 2013;40:1469-74.
48. Steenbergen HW, Huizinga TW, Helm-van Mil AH. The preclinical phase of rheumatoid arthritis: what is acknowledged and what needs to be assessed? Arthritis Rheum 2013;65:2219-32.
49. Willer B, Stucki G, Hoppeler H, Brühlmann P, Krähenbühl S. Effects of creatine supplementation on muscle weakness in patients with rheumatoid arthritis. Rheumatology 2000;39:293-8.
50. Wilkinson TJ, Lemmey AB, Jones JG et al. Can creatine supplementation improve body composition and objective physical function in rheumatoid arthritis patients? A randomised controlled trial. Arthritis Care Res 2015 doi: 10.1002/acr.22747. [Epub ahead of print]