Subcutaneous injection depth does not affect the pharmacokinetics or glucodynamics of insulin lispro in normal weight or healthy obese subjects

Journal of Diabetes Science and Technology

Volumn 9, Issue 4, 2015, Pages 824-830

  De La Peña, Amparo ^a   Yeo, Kwee P ^b   Linnebjerg, Helle ^a   Catton, Edward ^a   Reddy, Shobha ^a   Brown Augsburger, Patricia ^a   Morrow, Linda ^c   Ignaut, Debra A ^a  

^a ELI LILLY AND COMPANY   (United States)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c Profil Institute for Clinical Research   (United States)

Author keywords

Glucodynamics; Injection depth; Insulin lispro; Pharmacokinetics

Indexed keywords

GLUCOSE; INSULIN LISPRO; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD GLUCOSE MONITORING; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG DOSE; FEMALE; GLUCODYNAMIC PARAMETERS; GLUCOSE INFUSION; GLYCEMIC CONTROL; HUMAN; HYPERINSULINEMIC-EUGLYCEMIC CLAMP TECHNIQUE; LIMIT OF QUANTITATION; MALE; MEASUREMENT ACCURACY; MEASUREMENT PRECISION; OBESITY; PHARMACOKINETIC PARAMETERS; PHARMACOLOGICAL PARAMETERS; RADIOIMMUNOASSAY; SINGLE DRUG DOSE; VALIDATION PROCESS; ANALYSIS; BODY WEIGHT; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; METHODOLOGY; MIDDLE AGED; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SUBCUTANEOUS DRUG ADMINISTRATION; YOUNG ADULT;

ADULT; AREA UNDER CURVE; BLOOD GLUCOSE; BODY MASS INDEX; BODY WEIGHT; CROSS-OVER STUDIES; FEMALE; GLUCOSE CLAMP TECHNIQUE; HEALTHY VOLUNTEERS; HUMANS; HYPOGLYCEMIC AGENTS; INJECTIONS, SUBCUTANEOUS; INSULIN LISPRO; MALE; MIDDLE AGED; OBESITY; RESEARCH DESIGN; YOUNG ADULT;

EID: 84991003313     PISSN: None     EISSN: 19322968     Source Type: Journal    
DOI: 10.1177/1932296815573865     Document Type: Article

References (15)

1. McKay M, Compion G, Lytzen L. A comparison of insulin injection needles on patients' perceptions of pain, handling, and acceptability: a randomized, open-label, crossover study in subjects with diabetes. Diabetes Technol Ther. 2009;11(3): 195-201.
2. Strauss KA, Hannet I, McGonigle J, et al. Ultra-short (5 mm) insulin needles: trial results and clinical recommendations. Practical Diabetes Int. 1999;16:218-221.
3. De Coninck C, Frid A, Gaspar R, et al. Results and analysis of the 2008-2009 Insulin Injection Technique Questionnaire survey. J Diabetes. 2010;2(3):168-179.
4. Thow JC, Home PD. Insulin injection technique: depth of injection is important. Brit Med J. 1990;301:3-4.
5. Frid A, Hirsch L, Gaspar R, et al. New injection recommendations for patients with diabetes. Diabetes Metab. 2010;36(suppl 2):S3-S18.
6. Gibney MA, Arce CH, Byron KJ, Hirsch LJ. Skin and subcutaneous adipose layer thickness in adults with diabetes at sites used for insulin injections: implications for needle length recommendations. Curr Med Res Opin. 2010;26(6):1519-1530.
7. Kreugel G, Keers JC, Kerstens MN, Wolffenbuttel BH. Randomized trial on the influence of the length of two insulin pen needles on glycemic control and patient preference in obese patients with diabetes. Diabetes Technol Ther. 2011;13(7): 737-741.
8. Ignaut DA, Fu H. Comparison of insulin diluent leakage postinjection using two different needle lengths and injection volumes in obese patients with type 1 or type 2 diabetes mellitus. J Diabetes Sci Technol. 2012;6(2):389-393.
9. Frid A, Linde B. Intraregional differences in the absorption of unmodified insulin from the abdominal wall. Diabet Med. 1992;9(3):236-239.
10. Hirsch LJ, Gibney MA, Albanese J, et al. Comparative glycemic control, safety and patient ratings for a new 4 mm x 32G insulin pen needle in adults with diabetes. Curr Med Res Opin. 2010;26(6):1531-1541.
11. Bergenstal R, Strock E, Peremislov D, Parvu V, Gibney M, Hirsch L. Insulin therapy with a 4 mm x 32G pen needle vs larger needles in obese subjects. Paper presented at: American Diabetes Association 73rd Scientific Session; June 2013; Chicago, IL.
12. Hirose T, Ogihara T, Tozaka S, Kanderian S, Watada H. Identification and comparison of insulin pharmacokinetics injected with a new 4-mm needle vs 6- and 8-mm needles accounting for endogenous insulin and C-peptide secretion kinetics in non-diabetic adult males. J Diabetes Investig. 2013;4(3):287-296.
13. Humalog (package insert). Indianapolis, IN: Eli Lilly and Company; 2007.
14. Nagai Y, Ohshige T, Arai K, et al. Comparison between shorter straight and thinner microtapered insulin injection needles. Diabetes Technol Ther. 2013;15(7):550-555.
15. Sim KH, Hwang MS, Kim SY, Lee HM, Chang JY, Lee MK. The appropriateness of the length of insulin needles based on determination of skin and subcutaneous fat thickness in the abdomen and upper arm in patients with type 2 diabetes [published correction in Diabetes Metab J. 2014;38(3):244]. Diabetes Metab J. 2014;38(2):120-133.