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This study shows the excellent response that can be achieved using one of the all-oral IFN-free regimens in patients who failed prior treatment
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Feld JJ, Jacobson IM, Jensen DM, et al. Randomized study of danoprevir/ & ritonavir-based therapy for HCV genotype 1 patients with prior partial or null responses to peginterferon/ribavirin. J Hepatol 2015; 62:294–302. This study shows the excellent response that can be achieved using one of the all-oral IFN-free regimens in patients who failed prior treatment.
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Regimen was poorly tolerated in patients with advanced fibrosis
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This study outlines the outcome using the first-generation PIs combined with pegylated IFN and RBV to treat HCV in patients with kidney disease. SVR rates were high but regimen was associated with high rates of serious adverse events (46.6%). Regimen was poorly tolerated in patients with advanced fibrosis.
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28
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Another study reporting outcome of the use of first-generation PIs combined with pegylated IFN and RBV in patients with kidney disease. High rates of serious adverse events accompanied by high dropout rate (34.7%) limits the ability of its use in patients awaiting kidney transplant
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Saadoun D, Resche Rigon M, Thibault V, et al. Peg-IFNalpha/ribavirin/pro- & tease inhibitor combination in hepatitis C virus associated mixed cryoglobulinemia vasculitis: results at week 24. Ann Rheum Dis 2014; 73:831–837. Another study reporting outcome of the use of first-generation PIs combined with pegylated IFN and RBV in patients with kidney disease. High rates of serious adverse events accompanied by high dropout rate (34.7%) limits the ability of its use in patients awaiting kidney transplant.
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Baid-Agrawal S, Pascual M, Moradpour D, et al. Hepatitis C virus infection && and kidney transplantation in 2014: what’s new? Am J Transplant 2014; 14:2206–2220. This article is a very comprehensive up-to-date review of impact of HCV infection on patients with ESKD both before and after kidney transplant. It offers an assessment of the multiple treatment regimens available and several proposals regarding optimal timing of HCV treatment, criteria for combined listing for transplant, and criteria for the use of HCV-positive kidneys.
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Zeuzem S, Jacobson IM, Baykal T, et al. Retreatment of HCV with ABT-450/r- & ombitasvir and dasabuvir with ribavirin. N Engl J Med 2014; 370:1604–1614. This study outlines the high SVR rates with one of the currently available FDA-approved regimens to treat HCV genotype-1 infection. This regimen has the potential use in patients with kidney disease.
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Kwo PY, Mantry PS, Coakley E, et al. An interferon-free antiviral regimen for && HCV after liver transplantation. N Engl J Med 2014; 371:2375–2382. This study showed that this all-oral IFN-free regimen can be used post-liver transplant with high rate of SVR. This regimen can be associated with significant drug–drug interactions with calcineurin inhibitors and will require close monitoring of drug levels and may limit its wide use post-solid organ transplant.
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