Oral and Conjunctival Exposure of Nonhuman Primates to Low Doses of Ebola Makona Virus

Journal of Infectious Diseases

Volumn 214, Issue , 2016, Pages S263-S267

  Mire, Chad E ^a,b   Geisbert, Joan B ^a,b   Agans, Krystle N ^a,b   Deer, Daniel J ^a,b   Fenton, Karla A ^a,b   Geisbert, Thomas W ^a,b  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Ebola virus; Nonhuman primate; Pathogenesis

Indexed keywords

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EBOLA HEMORRHAGIC FEVER; EBOLA MAKONA VIRUS; EBOLAVIRUS; EXPOSURE; LETHALITY; NONHUMAN; PRIMATE; PRIORITY JOURNAL; VIREMIA; VIRUS CONJUNCTIVAL EXPOSURE; VIRUS ORAL EXPOSURE; VIRUS PLAQUE; VIRUS STRAIN; VIRUS VIRULENCE; ANIMAL; CONJUNCTIVA; DISEASE MODEL; FEMALE; HUMAN; MACACA FASCICULARIS; MALE; MOUTH; PATHOGENICITY; PATHOLOGY; VIROLOGY;

VIRUS RNA;

ANIMALS; CONJUNCTIVA; DISEASE MODELS, ANIMAL; EBOLAVIRUS; FEMALE; HEMORRHAGIC FEVER, EBOLA; HUMANS; MACACA FASCICULARIS; MALE; MOUTH; RNA, VIRAL; VIREMIA;

EID: 84990942794     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiw149     Document Type: Article

References (12)

1. Feldmann H, Sanchez A, Geisbert TW. Filoviridae. In: Knipe DM, Howley PM, eds. Field's virology. Philadelphia, PA: Lippincott Williams & Wilkins, 2013:923-56.
2. World Health Organization. Ebola situation report, 2016. http://apps.who.int/iris/bitstream/10665/204172/1/ebolasitrep-20Jan2016-eng.pdf?ua=1. Accessed 4 April 2016.
3. Marzi A, Feldmann F, Hanley PW, Scott DP, Günther S, Feldmann H. Delayed disease progression in cynomolgus macaques infected with Ebola virus Makona strain. Emerg Infect Dis 2015; 21:1777-83.
4. Johnston SC, Lin KL, Twenhafel NA, et al. Dose response of MARV/Angola infection in cynomolgus macaques following IM or aerosol exposure. PLoS One 2015; 10:e0138843.
5. Alves DA, Glynn AR, Steele KE, et al. Aerosol exposure to the Angola strain of Marburg virus causes lethal viral hemorrhagic Fever in cynomolgus macaques. Vet Pathol 2010; 47:831-51.
6. Zumbrun EE, Bloomfield HA, Dye JM, et al. A characterization of aerosolized Sudan virus infection in African green monkeys, cynomolgus macaques, and rhesus macaques. Viruses 2012; 4:2115-36.
7. Sullivan NJ, Sanchez A, Rollin PE, Yang ZY, Nabel GJ. Development of a preventive vaccine for Ebola virus infection in primates. Nature 2000; 408:605-9.
8. Sullivan NJ, Geisbert TW, Geisbert JB, et al. Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates. Nature 2003; 424:681-4.
9. Reed DS, Lackemeyer MG, Garza NL, Sullivan LJ, Nichols DK. Aerosol exposure to Zaire ebolavirus in three nonhuman primate species: differences in disease course and clinical pathology. Microbes Infect 2011; 13:930-6.
10. Jaax NK, Davis KJ, Geisbert TW, et al. Lethal experimental infection of rhesus monkeys with Ebola-Zaire (Mayinga) virus by the oral and conjunctival route of exposure. Arch Pathol Lab Med 1996; 120:140-55.
11. Mire CE, Matassov D, Geisbert JB, et al. Single-dose attenuated Vesiculovax vaccines protect primates against Ebola Makona virus. Nature 2015; 520:688-91.
12. Thi EP, Mire CE, Lee AC, et al. Lipid nanoparticle siRNA treatment of Ebolavirus-Makona-infected nonhuman primates. Nature 2015; 521:362-5.