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Volumn 67, Issue 10, 2016, Pages 902-908

The Antiplatelet Effect of Clopidogrel Decreases with Patient Age

Author keywords

age; clopidogrel; flow cytometry; platelet activation

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; GLYCOPROTEIN IB ALPHA; GLYCOPROTEIN IIB; GLYCOPROTEIN IIIA; PADGEM PROTEIN; ADENOSINE DIPHOSPHATE; ANTITHROMBOCYTIC AGENT; FIBRINOGEN RECEPTOR; TICLOPIDINE;

EID: 84990853792     PISSN: 00033197     EISSN: 19401574     Source Type: Journal    
DOI: 10.1177/0003319716631249     Document Type: Article
Times cited : (11)

References (35)
  • 1
    • 75949128633 scopus 로고    scopus 로고
    • Antiplatelet therapies for the treatment of cardiovascular disease
    • Michelson AD,. Antiplatelet therapies for the treatment of cardiovascular disease. Nat Rev Drug Discov. 2010; 9 (2): 154-169.
    • (2010) Nat Rev Drug Discov , vol.9 , Issue.2 , pp. 154-169
    • Michelson, A.D.1
  • 2
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
    • Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK,. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001; 345 (7): 494-502.
    • (2001) N Engl J Med , vol.345 , Issue.7 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Mehta, S.R.3    Chrolavicius, S.4    Tognoni, G.5    Fox, K.K.6
  • 3
    • 33646253693 scopus 로고    scopus 로고
    • P2Y12 receptor antagonists: A rapidly expanding group of antiplatelet agents
    • Cattaneo M,. P2Y12 receptor antagonists: a rapidly expanding group of antiplatelet agents. Eur Heart J. 2006; 27 (9): 1010-1012.
    • (2006) Eur Heart J , vol.27 , Issue.9 , pp. 1010-1012
    • Cattaneo, M.1
  • 4
    • 70349868299 scopus 로고    scopus 로고
    • Smoking promotes clopidogrel-mediated platelet inhibition in patients receiving dual antiplatelet therapy
    • Gremmel T, Steiner S, Seidinger D, Koppensteiner R, Panzer S, Kopp CW,. Smoking promotes clopidogrel-mediated platelet inhibition in patients receiving dual antiplatelet therapy. Thromb Res. 2009; 124 (5): 588-591.
    • (2009) Thromb Res , vol.124 , Issue.5 , pp. 588-591
    • Gremmel, T.1    Steiner, S.2    Seidinger, D.3    Koppensteiner, R.4    Panzer, S.5    Kopp, C.W.6
  • 5
    • 84884557023 scopus 로고    scopus 로고
    • Chronic kidney disease is associated with increased platelet activation and poor response to antiplatelet therapy
    • Gremmel T, Müller M, Steiner S, et al. Chronic kidney disease is associated with increased platelet activation and poor response to antiplatelet therapy. Nephrol Dial Transpl. 2013; 28 (8): 2116-2122.
    • (2013) Nephrol Dial Transpl , vol.28 , Issue.8 , pp. 2116-2122
    • Gremmel, T.1    Müller, M.2    Steiner, S.3
  • 6
    • 84876396282 scopus 로고    scopus 로고
    • Obesity is associated with poor response to clopidogrel and an increased susceptibility to protease activated receptor-1 mediated platelet activation
    • Gremmel T, Steiner S, Seidinger D, Koppensteiner R, Panzer S, Kopp CW,. Obesity is associated with poor response to clopidogrel and an increased susceptibility to protease activated receptor-1 mediated platelet activation. Transl Res. 2013; 161 (5): 421-429.
    • (2013) Transl Res , vol.161 , Issue.5 , pp. 421-429
    • Gremmel, T.1    Steiner, S.2    Seidinger, D.3    Koppensteiner, R.4    Panzer, S.5    Kopp, C.W.6
  • 7
    • 79961059632 scopus 로고    scopus 로고
    • Clinical, genetic and confounding factors determine the dynamics of the in vitro response/non response to clopidogrel
    • Gremmel T, Panzer S,. Clinical, genetic and confounding factors determine the dynamics of the in vitro response/non response to clopidogrel. Thromb Haemost. 2011; 106 (2): 211-218.
    • (2011) Thromb Haemost , vol.106 , Issue.2 , pp. 211-218
    • Gremmel, T.1    Panzer, S.2
  • 8
    • 84877772588 scopus 로고    scopus 로고
    • Differential impact of cytochrome 2C9 allelic variants on clopidogrel-mediated platelet inhibition determined by five different platelet function tests
    • Gremmel T, Kopp CW, Seidinger D, et al. Differential impact of cytochrome 2C9 allelic variants on clopidogrel-mediated platelet inhibition determined by five different platelet function tests. Int J Cardiol. 2013; 166 (1): 126-131.
    • (2013) Int J Cardiol , vol.166 , Issue.1 , pp. 126-131
    • Gremmel, T.1    Kopp, C.W.2    Seidinger, D.3
  • 10
    • 38349065084 scopus 로고    scopus 로고
    • Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin. the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study
    • Gilard M, Arnaud B, Cornily JC, et al. Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin. the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study. J Am Coll Cardiol. 2008; 51 (3): 256-260.
    • (2008) J Am Coll Cardiol , vol.51 , Issue.3 , pp. 256-260
    • Gilard, M.1    Arnaud, B.2    Cornily, J.C.3
  • 11
    • 46749087824 scopus 로고    scopus 로고
    • Baseline platelet activity and response after clopidogrel in 257 diabetics among 822 patients with coronary artery disease
    • Serebruany V, Pokov I, Kuliczkowski W, Chesebro J, Badimon J,. Baseline platelet activity and response after clopidogrel in 257 diabetics among 822 patients with coronary artery disease. Thromb Haemost. 2008; 100 (1): 76-82.
    • (2008) Thromb Haemost , vol.100 , Issue.1 , pp. 76-82
    • Serebruany, V.1    Pokov, I.2    Kuliczkowski, W.3    Chesebro, J.4    Badimon, J.5
  • 12
    • 56849130022 scopus 로고    scopus 로고
    • Patients with poor responsiveness to thienopyridine treatment or with diabetes have lower levels of circulating active metabolite, but their platelets respond normally to active metabolite added ex vivo
    • Erlinge D, Varenhorst C, Braun OO, et al. Patients with poor responsiveness to thienopyridine treatment or with diabetes have lower levels of circulating active metabolite, but their platelets respond normally to active metabolite added ex vivo. J Am Coll Cardiol. 2008; 52 (24): 1968-1977.
    • (2008) J Am Coll Cardiol , vol.52 , Issue.24 , pp. 1968-1977
    • Erlinge, D.1    Varenhorst, C.2    Braun, O.O.3
  • 13
    • 84860451417 scopus 로고    scopus 로고
    • Influence of cytochrome 2C19 allelic variants on on-treatment platelet reactivity evaluated by five different platelet function tests
    • Gremmel T, Kopp CW, Moertl D, et al. Influence of cytochrome 2C19 allelic variants on on-treatment platelet reactivity evaluated by five different platelet function tests. Thromb Res. 2012; 129 (5): 616-622.
    • (2012) Thromb Res , vol.129 , Issue.5 , pp. 616-622
    • Gremmel, T.1    Kopp, C.W.2    Moertl, D.3
  • 14
    • 76149100609 scopus 로고    scopus 로고
    • Calcium-channel blockers decrease clopidogrel-mediated platelet inhibition
    • Gremmel T, Steiner S, Seidinger D, Koppensteiner R, Panzer S, Kopp CW,. Calcium-channel blockers decrease clopidogrel-mediated platelet inhibition. Heart. 2010; 96 (3): 186-189.
    • (2010) Heart , vol.96 , Issue.3 , pp. 186-189
    • Gremmel, T.1    Steiner, S.2    Seidinger, D.3    Koppensteiner, R.4    Panzer, S.5    Kopp, C.W.6
  • 15
    • 84890025521 scopus 로고    scopus 로고
    • Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding
    • Tantry US, Bonello L, Aradi D, et al. Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding. J Am Coll Cardiol. 2013; 62 (24): 2261-2273.
    • (2013) J Am Coll Cardiol , vol.62 , Issue.24 , pp. 2261-2273
    • Tantry, U.S.1    Bonello, L.2    Aradi, D.3
  • 16
    • 60949083948 scopus 로고    scopus 로고
    • Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis
    • Sibbing D, Braun S, Morath T, et al. Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis. J Am Coll Cardiol. 2009; 53 (10): 849-856.
    • (2009) J Am Coll Cardiol , vol.53 , Issue.10 , pp. 849-856
    • Sibbing, D.1    Braun, S.2    Morath, T.3
  • 17
    • 59849120163 scopus 로고    scopus 로고
    • Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay a 12-month follow-up
    • Marcucci R, Gori AM, Paniccia R, et al. Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay a 12-month follow-up. Circulation. 2009; 119 (2): 237-242.
    • (2009) Circulation , vol.119 , Issue.2 , pp. 237-242
    • Marcucci, R.1    Gori, A.M.2    Paniccia, R.3
  • 18
    • 73049113504 scopus 로고    scopus 로고
    • Adenosine diphosphate-inducible platelet reactivity shows a pronounced age dependency in the initial phase of antiplatelet therapy with clopidogrel
    • Gremmel T, Steiner S, Seidinger D, Koppensteiner R, Panzer S, Kopp CW,. Adenosine diphosphate-inducible platelet reactivity shows a pronounced age dependency in the initial phase of antiplatelet therapy with clopidogrel. J Thromb Haemost. 2010; 8 (1): 37-42.
    • (2010) J Thromb Haemost , vol.8 , Issue.1 , pp. 37-42
    • Gremmel, T.1    Steiner, S.2    Seidinger, D.3    Koppensteiner, R.4    Panzer, S.5    Kopp, C.W.6
  • 19
    • 84861386102 scopus 로고    scopus 로고
    • High on-thienopyridine platelet reactivity in elderly coronary patients: The SENIOR-PLATELET study
    • Silvain J, Cayla G, Hulot JS, et al. High on-thienopyridine platelet reactivity in elderly coronary patients: The SENIOR-PLATELET study. Eur Heart J. 2012; 33 (10): 1241-1250.
    • (2012) Eur Heart J , vol.33 , Issue.10 , pp. 1241-1250
    • Silvain, J.1    Cayla, G.2    Hulot, J.S.3
  • 20
    • 80255137260 scopus 로고    scopus 로고
    • Comparison of platelet reactivity and clopidogrel response in patients ≤75 years versus >75 years undergoing percutaneous coronary intervention for nonST-segment elevation acute coronary syndrome
    • Cuisset T, Quilici J, Grosdidier C, et al. Comparison of platelet reactivity and clopidogrel response in patients ≤75 years versus >75 years undergoing percutaneous coronary intervention for nonST-segment elevation acute coronary syndrome. Am J Cardiol. 2011; 108 (10): 1411-1416.
    • (2011) Am J Cardiol , vol.108 , Issue.10 , pp. 1411-1416
    • Cuisset, T.1    Quilici, J.2    Grosdidier, C.3
  • 21
    • 62449095155 scopus 로고    scopus 로고
    • Comparison of methods to evaluate clopidogrel-mediated platelet inhibition after percutaneous intervention with stent implantation
    • Gremmel T, Steiner S, Seidinger D, Koppensteiner R, Panzer S, Kopp CW,. Comparison of methods to evaluate clopidogrel-mediated platelet inhibition after percutaneous intervention with stent implantation. Thromb Haemost. 2009; 101 (2): 333-339.
    • (2009) Thromb Haemost , vol.101 , Issue.2 , pp. 333-339
    • Gremmel, T.1    Steiner, S.2    Seidinger, D.3    Koppensteiner, R.4    Panzer, S.5    Kopp, C.W.6
  • 22
    • 80955179559 scopus 로고    scopus 로고
    • The influencing factors for clopidogrel-mediated platelet inhibition are assay-dependent
    • Gremmel T, Steiner S, Seidinger D, Koppensteiner R, Panzer S, Kopp CW,. The influencing factors for clopidogrel-mediated platelet inhibition are assay-dependent. Thromb Res. 2011; 128 (4): 352-357.
    • (2011) Thromb Res , vol.128 , Issue.4 , pp. 352-357
    • Gremmel, T.1    Steiner, S.2    Seidinger, D.3    Koppensteiner, R.4    Panzer, S.5    Kopp, C.W.6
  • 23
    • 84893805623 scopus 로고    scopus 로고
    • In vivo and protease-activated receptor-1-mediated platelet activation but not response to antiplatelet therapy predict two-year outcomes after peripheral angioplasty with stent implantation
    • Gremmel T, Steiner S, Seidinger D, Koppensteiner R, Panzer S, Kopp CW,. In vivo and protease-activated receptor-1-mediated platelet activation but not response to antiplatelet therapy predict two-year outcomes after peripheral angioplasty with stent implantation. Thromb Haemost. 2014; 111 (3): 474-482.
    • (2014) Thromb Haemost , vol.111 , Issue.3 , pp. 474-482
    • Gremmel, T.1    Steiner, S.2    Seidinger, D.3    Koppensteiner, R.4    Panzer, S.5    Kopp, C.W.6
  • 24
    • 70450277303 scopus 로고    scopus 로고
    • The formation of monocyte-platelet aggregates is independent of on-treatment residual agonists'-inducible platelet reactivity
    • Gremmel T, Kopp CW, Seidinger D, et al. The formation of monocyte-platelet aggregates is independent of on-treatment residual agonists'-inducible platelet reactivity. Atherosclerosis. 2009; 207 (2): 608-613.
    • (2009) Atherosclerosis , vol.207 , Issue.2 , pp. 608-613
    • Gremmel, T.1    Kopp, C.W.2    Seidinger, D.3
  • 25
    • 84908874359 scopus 로고    scopus 로고
    • A platelet P-selectin test predicts adverse cardiovascular events in patients with acute coronary syndromes treated with aspirin and clopidogrel
    • Thomas MR, Wijeyeratne YD, May JA, Johnson A, Heptinstall S, Fox SC,. A platelet P-selectin test predicts adverse cardiovascular events in patients with acute coronary syndromes treated with aspirin and clopidogrel. Platelets. 2014; 25 (8): 612-618.
    • (2014) Platelets , vol.25 , Issue.8 , pp. 612-618
    • Thomas, M.R.1    Wijeyeratne, Y.D.2    May, J.A.3    Johnson, A.4    Heptinstall, S.5    Fox, S.C.6
  • 27
    • 84931292070 scopus 로고    scopus 로고
    • Impact of variables of the P-selectin - P-selectin glycoprotein ligand-1 axis on leukocyte-platelet interactions in cardiovascular disease
    • Gremmel T, Koppensteiner R, Kaider A, Eichelberger B, Mannhalter C, Panzer S,. Impact of variables of the P-selectin-P-selectin glycoprotein ligand-1 axis on leukocyte-platelet interactions in cardiovascular disease. Thromb Haemost. 2015; 113 (4): 806-812.
    • (2015) Thromb Haemost , vol.113 , Issue.4 , pp. 806-812
    • Gremmel, T.1    Koppensteiner, R.2    Kaider, A.3    Eichelberger, B.4    Mannhalter, C.5    Panzer, S.6
  • 28
    • 84856686739 scopus 로고    scopus 로고
    • Upregulation of CD40 ligand and enhanced monocyte-platelet aggregate formation are associated with worse clinical outcome after ischaemic stroke
    • Lukasik M, Dworacki G, Kufel-Grabowska J, Watala C, Kozubski W,. Upregulation of CD40 ligand and enhanced monocyte-platelet aggregate formation are associated with worse clinical outcome after ischaemic stroke. Thromb Haemost. 2012; 107 (2): 346-355.
    • (2012) Thromb Haemost , vol.107 , Issue.2 , pp. 346-355
    • Lukasik, M.1    Dworacki, G.2    Kufel-Grabowska, J.3    Watala, C.4    Kozubski, W.5
  • 29
    • 0035949524 scopus 로고    scopus 로고
    • Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin: Studies in baboons, human coronary intervention, and human acute myocardial infarction
    • Michelson AD, Barnard MR, Krueger LA, Valeri CR, Furman MI,. Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin: Studies in baboons, human coronary intervention, and human acute myocardial infarction. Circulation. 2001; 104 (13): 1533-1537.
    • (2001) Circulation , vol.104 , Issue.13 , pp. 1533-1537
    • Michelson, A.D.1    Barnard, M.R.2    Krueger, L.A.3    Valeri, C.R.4    Furman, M.I.5
  • 30
    • 0022180156 scopus 로고
    • Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation
    • Shattil SJ, Hoxie JA, Cunningham M, Brass LF,. Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation. J Biol Chem. 1985; 260 (20): 11107-11114.
    • (1985) J Biol Chem , vol.260 , Issue.20 , pp. 11107-11114
    • Shattil, S.J.1    Hoxie, J.A.2    Cunningham, M.3    Brass, L.F.4
  • 32
    • 84936980823 scopus 로고    scopus 로고
    • Comparison of aggregometry with flow cytometry for the assessment of agonists'-induced platelet reactivity in patients on dual antiplatelet therapy
    • Gremmel T, Koppensteiner R, Panzer S,. Comparison of aggregometry with flow cytometry for the assessment of agonists'-induced platelet reactivity in patients on dual antiplatelet therapy. PLoS One. 2015; 10 (6): e0129666.
    • (2015) PLoS One , vol.10 , Issue.6 , pp. e0129666
    • Gremmel, T.1    Koppensteiner, R.2    Panzer, S.3
  • 33
    • 0031783832 scopus 로고    scopus 로고
    • In vivo age-related changes in hepatic drug-oxidizing capacity in humans
    • Tanaka E,. In vivo age-related changes in hepatic drug-oxidizing capacity in humans. J Clin Pharm Ther. 1998; 23 (4): 247-255.
    • (1998) J Clin Pharm Ther , vol.23 , Issue.4 , pp. 247-255
    • Tanaka, E.1
  • 34
    • 0021032982 scopus 로고
    • Impairment of lidocaine clearance in elderly male subjects
    • Abernethy DR, Greenblatt DJ,. Impairment of lidocaine clearance in elderly male subjects. J Cardiovasc Pharm. 1983; 5 (6): 1093-1096.
    • (1983) J Cardiovasc Pharm , vol.5 , Issue.6 , pp. 1093-1096
    • Abernethy, D.R.1    Greenblatt, D.J.2
  • 35
    • 84874550138 scopus 로고    scopus 로고
    • Clopidogrel pharmacokinetics and pharmacodynamics vary widely despite exclusion or control of polymorphisms (CYP2C19, ABCB1, PON1), noncompliance, diet, smoking, co-medications (including proton pump inhibitors), and pre-existent variability in platelet function
    • Frelinger AL III, Bhatt DL, Lee RD, et al. Clopidogrel pharmacokinetics and pharmacodynamics vary widely despite exclusion or control of polymorphisms (CYP2C19, ABCB1, PON1), noncompliance, diet, smoking, co-medications (including proton pump inhibitors), and pre-existent variability in platelet function. J Am Coll Cardiol. 2013; 61 (8): 872-879.
    • (2013) J Am Coll Cardiol , vol.61 , Issue.8 , pp. 872-879
    • Frelinger, A.L.1    Bhatt, D.L.2    Lee, R.D.3


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