The Cost-Benefit of Federal Investment in Preventing Clostridium difficile Infections through the Use of a Multifaceted Infection Control and Antimicrobial Stewardship Program

Infection Control and Hospital Epidemiology

Volumn 36, Issue 6, 2015, Pages 681-687

  Slayton, Rachel B ^a   Scott, R Douglas ^a   Baggs, James ^a   Lessa, Fernanda C ^a   McDonald, L Clifford ^a   Jernigan, John A ^a  

^a NATIONAL CENTER FOR EMERGING AND ZOONOTIC INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT;

AGED; ANTIBIOTIC THERAPY; ANTIMICROBIAL STEWARDSHIP PROGRAM; ARTICLE; CLOSTRIDIUM DIFFICILE INFECTION; COHORT ANALYSIS; COMMUNITY ACQUIRED INFECTION; COST BENEFIT ANALYSIS; COST CONTROL; EMERGENCY CARE; FEMALE; GOVERNMENT; HEALTH CARE COST; HEALTH PROGRAM; HOSPITAL INFECTION; HOSPITAL PATIENT; HOSPITALIZATION; HUMAN; INFECTION CONTROL; INFECTION PREVENTION; MAJOR CLINICAL STUDY; MALE; MEDICARE; NONHUMAN; PEPTOCLOSTRIDIUM DIFFICILE; PROGRAM EFFECTIVENESS; UNITED STATES; VERY ELDERLY; CROSS INFECTION; ECONOMICS; ENTEROCOLITIS, PSEUDOMEMBRANOUS; MARKOV CHAIN; MEDICATION THERAPY MANAGEMENT; PATHOGENICITY; PROCEDURES; PUBLIC HEALTH; SAFETY; STATISTICS AND NUMERICAL DATA;

AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; CLOSTRIDIUM DIFFICILE; COST-BENEFIT ANALYSIS; CROSS INFECTION; ENTEROCOLITIS, PSEUDOMEMBRANOUS; HUMANS; INFECTION CONTROL; MARKOV CHAINS; MEDICATION THERAPY MANAGEMENT; NATIONAL HEALTH PROGRAMS; SAFETY MANAGEMENT; UNITED STATES;

EID: 84990308916     PISSN: 0899823X     EISSN: 15596834     Source Type: Journal    
DOI: 10.1017/ice.2015.43     Document Type: Article

References (35)

1. Lessa FC, Gould CV,McDonald LC. Current status of Clostridium difficile infection epidemiology. Clin Infect Dis 2012;55:S65-S70.
2. Lucado J, Gould C, Elixhauser A. Clostridium difficile infections (CDI) in hospital stays, 2009: Statistical Brief #124 Healthcare Cost and Utilization Project (HCUP) Statistical Briefs. Rockville, MD: Agency for Health Care Policy and Research, 2006.
3. Dubberke ER, Olsen MA. Burden of Clostridium difficile on the healthcare system. Clin Infect Dis 2012;55(Suppl 2):S88-S92.
4. McGlone SM, Bailey RR, Zimmer SM, et al. The economic burden of Clostridium difficile. Clin Microbiol Infect 2012;18:282-289.
5. Bradley T, Topoleski J. An overview of the medicare program. Congressional Budget office website. http://www.cbo.gov/pub lication/44587. Published 2013. Accessed May 2014.
6. Clostridium difficile infection: how to deal with the problem. Public Health England website. http://www.hpa.org.uk/webc/HPAwebFile/HPAweb-C/1232006607827. Published 2008. Accessed October 23, 2013.
7. Summary points on Clostridium difficile Infection (CDI). Public Health England website. http://www.hpa.org.uk/webc/HPA webFile/HPAweb-C/1278944283388. Published 2013. Accessed October 9, 2013.
8. Operational guidance for HPUs on HCAI in health/social care. Public Health England website. http://www.hpa.org.uk/hpr/archives/2012/hpr2912.pdf. Published 2012. Accessed October 9, 2013.
9. Ashiru-Oredope D, Sharland M, Charani E, McNulty C, Cooke J, Group AAS. Improving the quality of antibiotic prescribing in the NHS by developing a new antimicrobial stewardship programme: start smart-then focus. J Antimicrob Chemotherapy 2012;67: i51-i63.
10. Cohen SH, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol 2010;31:431-455.
11. Antimicrobial Use and Resistance (AUR) module. Centers for Disease Control and Prevention website. http://www.cdc.gov/nhsn/PDFs/pscManual/11pscAURcurrent.pdf. Published 2013. Accessed September 25, 2013.
12. Dubberke ER, Butler AM, Nyazee HA, et al. The impact of ICD-9-CM code rank order on the estimated prevalence of Clostridium difficile infections. Clin Infect Dis 2011;53:20-25.
13. Baggs J, Yousey-Hindes K, Dodds-Ashley E, et al. Identification of "high" risk population for future Clostridium difficile infection (CDI) paper presented at IDWeek2013; October 2-6, 2013, San Francisco, California. 14. Annual survey database. American Hospital Association website. http://www.ahadata.com/ahadata/html/AHASurvey.html. Published 2012. Accessed September 25, 2013.
14. Emerging infections program: healthcare associated infections project. Centers for Disease Control and Prevention website. http://www.cdc.gov/hai/eip/clostridium-difficile.html. Published 2012. Accessed September 30, 2013.
15. CMS Medicare Provider Analysis and Review (MEDPAR) file, 2008 and 2009. Centers for Medicare & Medicaid Services website. http://www.cms.gov/Research-Statistics-Data-and-Systems/Statistics-Trends-and-Reports/MedicareFeeforSvcPartsAB/MEDPAR. html. Published 2011. Accessed June 2013.
16. Yi SH, Baggs J, Gould CV, Scott RD, 2nd, Jernigan JA. Medicare reimbursement attributable to catheter-associated urinary tract infection in the inpatient setting: a retrospective cohort analysis. Med Care 2014;52:469-478.
17. Malpiedi PJ, Peterson KD, Soe MM. 2011 National and state healthcare-associated infection standardization infection ratio report. Atlanta, GA: Centers for Disease Control and Prevention, 2013.
18. Chronic Condition Data Warehouse website. https://www.ccwdata. org/web/guest/home. Published 2013. Accessed September 25, 2013.
19. Archived Consumer Price Index Detailed Report Information. Bureau of Labor Statistics website. http://www.bls.gov/cpi/cpi-dr.htm#2012. Published 2013. Accessed May 2014.
20. Palmer HR, Weston J, Gentry L, et al. Improving patient care through implementation of an antimicrobial stewardship program. AJHP 2011;68:2170-2174.
21. Beardsley JR, Williamson JC, Johnson JW, Luther VP, Wrenn RH, Ohl CC. Show me the money: long-term financial impact of an antimicrobial stewardship program. Infect Control Hosp Epidemiol 2012;33:398-400.
22. Standiford HC, Chan S, Tripoli M, Weekes E, Forrest GN. Antimicrobial stewardship at a large tertiary care academic medical center: cost analysis before, during, and after a 7-year program. Infect Control Hosp Epidemiol 2012;33:338-345.
23. Sick AC, Lehmann CU, Tamma PD, Lee CK, Agwu AL. Sustained savings from a longitudinal cost analysis of an internet-based preapproval antimicrobial stewardship program. Infect Control Hosp Epidemiol 2013;34:573-580.
24. Owens RC Jr., Donskey CJ, Gaynes RP, Loo VG, Muto CA. Antimicrobial-associated risk factors for Clostridium difficile infection. Clin Infect Dis 2008;46(Suppl 1):S19-S31.
25. Davey P, Brown E, Charani E, et al. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Revs 2013;4:CD003543.
26. Valiquette L, Cossette B, Garant MP, Diab H, Pepin J. Impact of a reduction in the use of high-risk antibiotics on the course of an epidemic of Clostridium difficile-associated disease caused by the hypervirulent NAP1/027 strain. Clin Infect Dis 2007;45:S112-S121.
27. Society for Healthcare Epidemiology of America; Infectious Diseases Society of America; Pediatric Infectious Diseases Society. Policy statement on antimicrobial stewardship by the Society for Healthcare Epidemiology of America (SHEA), the Infectious Diseases Society of America (IDSA), and the Pediatric Infectious Diseases Society (PIDS). Infect Control Hosp Epidemiol 2012;33:322-327.
28. Fact sheets: CMS proposals to improve quality of care during hospital inpatient stays. Centers for Medicare and Medicaid Services website. http://www.cms.gov/Newsroom/MediaRelease Database/Fact-Sheets/2013-Fact-Sheets-Items/2013-04-262.html. Published 2013. Accessed October 17, 2013.
29. Overview of the Nationwide Inpatient Sample (NIS). Healthcare Cost and Utilization Project (HCUP) website. www.hcup-us. ahrq.gov/nisoverview.jsp. Published 2013. Accessed September 25, 3013.
30. Sievert DM, Ricks P, Edwards JR, et al. Antimicrobialresistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009-2010. Infect Control Hosp Epidemiol 2013;34:1-14.
31. Jernigan JA, Clemence MA, Stott GA, et al. Control of methicillinresistant Staphylococcus aureus at a university hospital: one decade later. Infect Control Hosp Epidemiol 1995;16:686-696.
32. Puzniak LA, Gillespie KN, Leet T, Kollef M, Mundy LM. A costbenefit analysis of gown use in controlling vancomycin-resistant Enterococcus transmission: is it worth the price Infect Control Hosp Epidemiol 2004;25:418-424.
33. May 2011 National Occupational Employment andWage Estimates United States. Bureau of Labor Statistics website. www.bls.gov/oes/current/oes-nat.htm. Published 2013. Accessed September 25, 2013.
34. Clean Quick Liquid Quaternary Sanitizer. Janitor's World website. www.janitors-world.com/clquliqusa.html. Published 2013. Accessed October 28, 2013.
35. Dispatch Hospital Cleaner Disinfectants with Bleach. Staples website. http://www.staples.com/Dispatch-Hospital-Cleaner-Disinfectantswith-Bleach-128-oz-Refill-4-Pack/product-109677. Published 2013. Accessed October 28, 2013.