Patterns of peripheral cytokine expression during pregnancy in two cohorts and associations with inflammatory markers in cord blood

American Journal of Reproductive Immunology

Volumn 76, Issue 5, 2016, Pages 406-414

  Ross, Kharah MacKenzie ^a   Miller, Gregory ^b   Culhane, Jennifer ^c,d   Grobman, William ^e,f   Simhan, Hyagriv N ^g,h   Wadhwa, Pathik D ⁱ   Williamson, Douglas ^j   McDade, Thomas ^b   Buss, Claudia ^i,k   Entringer, Sonja ^i,k   Adam, Emma ^b   Qadir, Sameen ^l   Keenan Devlin, Lauren ^m   Leigh, Adam K K ^b   Borders, Ann ^e,f,m  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

^f Institute for Public Health and Medicine   (United States)

^g UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF PITTSBURGH   (United States)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^k CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^l WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^m NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

more..

Author keywords

cord blood; inflammation; pregnancy

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR;

ADULT; ARTICLE; COHORT ANALYSIS; FEMALE; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; PREGNANCY; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UMBILICAL CORD BLOOD;

EID: 84990232766     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/aji.12563     Document Type: Article

References (31)

1. Cunningham GF, Leveno KJ, Bloom SL, Hauth JC, Rouse DJ, Song CY. Williams Obstetrics, 24th edn. New York, NY: McGraw Hill Professional; 2014.
2. Mor G, Cardenas I, Abrahams V, Guller S. Inflammation and pregnancy: the role of the immune system at the implantation site. Ann N Y Acad Sci. 2011;1221:80–87.
3. Christian LM, Porter K. Longitudinal changes in serum proinflammatory markers across pregnancy and postpartum: effects of maternal body mass index. Cytokine. 2014;70:134–140.
4. Ferguson KK, McElrath TF, Chen YH, Mukherjee B, Meeker JD. Longitudinal profiling of inflammatory cytokines and C-reactive protein during uncomplicated and preterm pregnancy. Am J Reprod Immunol. 2014;72:326–336.
5. Coussons-Read ME, Okun ML, Nettles CD. Psychosocial stress increases inflammatory markers and alters cytokine production across pregnancy. Brain Behav Immun. 2007;21:343–350.
6. Denney JM, Nelson EL, Wadhwa PD, et al. Longitudinal modulation of immune system cytokine profile during pregnancy. Cytokine. 2011;53:170–177.
7. Holmes VA, Wallace JMW, Gilmore WS, McFaul P, Alexander HD. Plasma levels of the immunomodulatory cytokine interleukin-10 during normal human pregnancy: a longitudinal study. Cytokine. 2003;21:265–269.
8. Kraus TA, Sperling RS, Engel SM, et al. Peripheral blood cytokine profiling during pregnancy and post-partum periods. Am J Reprod Immunol. 2010;64:411–426.
9. Kronborg CS, Gjedsted J, Vittinghus E, Hansen TK, Allen J, Knudsen UB. Longitudinal measurement of cytokines in pre-eclamptic and normotensive pregnancies. Acta Obstet Gynecol Scand. 2011;90:791–796.
10. Palm M, Axelsson O, Wernroth L, Larsson A, Basu S. Involvement of inflammation in normal pregnancy. Acta Obstet Gynecol Scand. 2013;92:601–605.
11. Stewart FM, Freeman DJ, Ramsay JE, Greer IA, Caslake M, Ferrell WR. Longitudinal assessment of maternal endothelial function and markers of inflammation and placental function throughout pregnancy in lean and obese mothers. J Clin Endocrinol Metab. 2007;92:969–975.
12. Vassiliadis S, Freeman DJ, Ramsay JE, Greer IA, Caslake M, Ferrell WR. Serum levels of pro- and anti-inflammatory cytokines in non-pregnant women, during pregnancy, labour and abortion. Mediators Inflamm. 1998;7:69–72.
13. Wong HL, Pfeiffer RM, Fears TR, Vermeulen R, Ji S, Rabkin CS. Reproducibility and correlations of multiplex cytokine levels in asymptomatic persons. Cancer Epidemiol Biomarkers Prev. 2008;17:3450–3456.
14. Turner JD, Faulkner H, Kamgno J, et al. Th2 cytokines are associated with reduced worm burdens in a human intestinal helminth infection. J Infect Dis. 2003;188:1768–1775.
15. Hanley AJ, Festa A, D'Agostino, RB Jr, et al. Metabolic and inflammation variable clusters and prediction of type 2 diabetes: factor analysis using directly measured insulin sensitivity. Diabetes. 2004;53:1773–1781.
16. Tziakas DN, Chalikias GK, Kaski JC, et al. Inflammatory and anti-inflammatory variable clusters and risk prediction in acute coronary syndrome patients: a factor analysis approach. Atherosclerosis. 2007;193:196–203.
17. Dhabhar FS, Burke HM, Epel ES, et al. Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major depression. J Psychiatr Res. 2009;43:962–969.
18. Ng PC, Li K, Wong RPO, et al. Proinflammatory and anti-inflammatory cytokine responses in preterm infants with systemic infection. Arch Dis Child Fetal Neonatal Ed. 2003;88:F209–F213.
19. Dalfra MG, Fedele D, Ragazzi E, et al. Elevations of inflammatory cytokines during and after pregnancy in gestational diabetes. J Endocrinol Invest. 2009;32:289–290.
20. Jonakait GM. The effects of maternal inflammation on neuronal development: possible mechanisms. Int J Dev Neurosci. 2007;25:415–425.
21. Hagberg H, Mallard C, Ferriero DM, et al. The role of inflammation in perinatal brain injury. Nat Rev Neurol. 2015;11:192–208.
22. Entringer S, Buss C, Wadhwa PD. Prenatal stress and developmental programming of human health and disease risk: concepts and integration of empirical findings. Curr Opin Endocrinol Diabetes Obes. 2010;17:507–516.
23. Gaillard R, Rifas-Shiman SL, Perng W, Oken E, Gillman MW. Maternal inflammation during pregnancy and childhood adiposity. Obesity (Silver Spring). 2016;24:1320–1327.
24. Chow SS, Craig ME, Jones CA, et al. Differences in amniotic fluid and maternal serum cytokine levels in early midtrimester women without evidence of infection. Cytokine. 2008;44:78–84.
25. Shobokshi A, Shaarawy M. Maternal serum and amniotic fluid cytokines in patients with preterm premature rupture of membranes with and without intrauterine infection. Int J Gynaecol Obstet. 2002;79:209–215.
26. Corp I. IBM SPSS for Windows. 2013, Armonk, NY: IBM Corp.
27. Bennett DA. How can I deal with missing data in my study? Aust N Z J Public Health. 2001;25:464–469.
28. Petrovsky N, Harrison LC. The chronobiology of human cytokine production. Int Rev Immunol. 1998;16:635–649.
29. Osborne JW, Costello AB. Sample size and subject to item ratio in principal components analysis. Pract assess res eval. 2004;9.
30. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001;19:683–765.
31. McDade TW, Borja JB, Largado F, Adair LS, Kuzawa CW. Adiposity and chronic inflammation in young women predict inflammation during normal pregnancy in the Philippines. J Nutr. 2016;146:353–357.