2-Hydroxy-6-methylbenzoic acid derivatives

Synthesis (Germany)

Volumn 1980, Issue 10, 1980, Pages 814-815

  Hauser, Frank M ^a   Pogany, Stefano A ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84990143877     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-1980-29218     Document Type: Article

References (25)

1. Recipient of a Research Career Development Award 1978-82, from the National Cancer Institute (CA 00486).
2. Both 2-hydroxy-6-methylbenzoic acid and its methyl ester are naturally occurring compounds. The former is a common mold metabolite and the latter is a caste specific alarm pheromone for certain species of ants. We have extensively employed 5b and 5c in our natural products synthesis program. See:.
3. F. M. Hauser, R. P. Rhee, S. Pra-sanna, S. M. Weinreb, J. H. Dodd, Synthesis 1980, 72, and references therein.
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24. Commercial crotonaldehyde containing 15% water was cooled tn a freezer at-20°C then filtered to remove the water crystals. Subsequent distillation of the filtrate afforded pure croton-aldehyde.
25. The product at this point is probably the hydrogen chloride ad-duct of 4.