Ameliorative potential of Solanum trilobatum leaf extract and fractions on lipid profile and oxidative stress in experimental diabetes

Pakistan Journal of Pharmaceutical Sciences

Volumn 29, Issue 5, 2016, Pages 1571-1578

  Ahmed, Khader Syed Zameer ^a   Sidhra, Syed Zameer Ahmed ^a   Ponmurugan, Ponnusamy ^a   Kumar, Balasubramanian Senthil ^b  

^a K S RANGASAMY COLLEGE OF TECHNOLOGY   (India)

^b THIRUVALLUVAR UNIVERSITY   (India)

Author keywords

Alloxan; Antioxidant; Hyperglycemia; Hypolipidemic; Oxidative stress; Solanum trilobatum

Indexed keywords

ALCOHOL; AMINO ACID DERIVATIVE; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; ANTIOXIDANT; CAROTENOID; CATALASE; CHLOROPHYLL; CREATININE; FRUCTOSE BISPHOSPHATASE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUTATHIONE PEROXIDASE; GLYCOGEN; HEXOKINASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MINERAL; PLANT EXTRACT; PLANT PROTEIN; SOLANUM TRILOBATUM EXTRACT; SUGAR; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UREA; URIC ACID; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; ALLOXAN; BIOLOGICAL MARKER; GLUCOSE BLOOD LEVEL; LIPID;

ALLOXAN-INDUCED DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; ENZYME ASSAY; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; LIPID ANALYSIS; MALE; NONHUMAN; OXIDATIVE STRESS; PLANT LEAF; RAT; RENAL PROTECTION; SOLANUM TRILOBATUM; TOXICITY TESTING; ANIMAL; BLOOD; CHEMICALLY INDUCED; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; ISOLATION AND PURIFICATION; KIDNEY; MEDICINAL PLANT; METABOLISM; PHYTOTHERAPY; SOLANUM;

ALLOXAN; ANIMALS; ANTIOXIDANTS; BIOMARKERS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; KIDNEY; LIPIDS; MALE; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PLANTS, MEDICINAL; RATS; SOLANUM;

EID: 84989950872     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Abei H (1984). Catalase in vitro. In: Parker, L. (Ed.), Methods in Enzymology, Academic Press, New York, 105: 121-126.
2. AOAC (1990). Official methods of analysis of the association of official analytical chemists. 15th Edition.Voume 1 & 2. Helrich, K. (ed.). AOAC Inc. USA.
3. Arnon DI (1949). Copper enzymes in isolated chloroplasts Polyphenoloxidase in Beta vulgaris. Plant Physiol., 24: 1-15.
4. Bhagavan NV (2002). Metabolic homeostasis in: N.V.Bhagavan (Eds.) Med. Biochem. Harcourt/Academic, Florida, 485-519.
5. Bopanna KN, Kannan J, Sushma Gangil, Blaraman R and Rathod SP (1997). Antideiabetic and antilipidemic effects of Neem seed kernel powder on alloxan diabetic rabbits. IJP, 29: 162-167.
6. Claude B and Paule S (1979). The manual of natural living. 1st Ed. Biddles Ltd, pp.98-101.
7. Doss A and Anand SP (2012). Free radical scavenging activity of solanum trilobatum linn. on alloxan - Induced Diabetic Rats. Biochem. Anal Biochem., 1(6): 100-115.
8. Dubois M, Gills KA, Hamilton JK, Rebers PA and Smith F (1956). Estimation of total sugars by phenolsulphuric acid method. Anal. Chem., 26: 350.
9. Folch J, Less M and Sloane SGH (1957). A simple method for isolation and purification of total lipids from animal tissues. J. Biol. Chem., 226: 497-509.
10. Fraga CG, Leibouitz BE and Toppel AL (1988). Lipid per oxidation measured as TBARS in tissue slices: Characterization and comparison with homogenates and microsomes. Free Radic. Biol. Med., 155-161.
11. Friedwald J, Levy YR and Friedrickson SD (1972).Estimation of concentration of low-density lipoprotein cholesterol in plasma without use of preparative ultracentrifuge. Clinical Chemistry, 18: 499-502.
12. Ganong WF (1995). Review of Medical Physiology, 17th ed. Lange Med Public, London, USA. p.86.
13. Garber AJ (2000). Attenuating CV risk factors in patients with diabetes: Clinical evidence to clinical practice.Diabetes Obes Metab, 4: 5-12.
14. Garvey WT (1992). Glucose transport and NIDDM.Diabetes Care, 15: 396-417.
15. Gbolahan D (2001). Lesson note on medical importance of trace elements. Centre for Natural Health Studies; Surulere, Lagos, Nigeria.
16. Giugliano D Ceriello A and Paolisso G (1996). Oxidative stress and diabetic vascular complications. Diabetes Care, 19: 257-267.
17. Govindhan S, Viswanathan S, Viyasekaran V and Alagappan R (2004). Further studies on the clinical efficacy of Solanum xanthocarpum and Solanum trilobatum in bronchial asthma. Phytotherapy Res., 18: 805-809.
18. Grover SA, levington C and Paquet S (1999). Identifying adults at low risk for significant hyperglycemia: A validated clinical index. J. Clin. Epidemol., 52: 49-55.
19. Jasemine Shabeer, Radhey Shyam Srivastava and Sushil Kumar Singh (2009). Antidiabetic and antioxidant effect of various fractions of Phyllanthus simplex in alloxan diabetic rats. J. Ethnopharmacol., 124: 34-38.
20. Jiang ZY, Hunt JV and Wolff SP (1992). Ferrous ion oxidation in the presence of Xylenol orange for detection of lipid hydro peroxide in low-density lipoproteins. Ann. Biochem., 202: 384-387.
21. Joy KL and Kuttan R (1999). Anti-diabetic activity of Picrorrhiza kurroa extract. J. Ethnopharmacol., 67(2): 143-148.
22. Kakkar P, Das B and Vishwanathan PN (1984). A modified spectrophotometric assay of super oxide dismutase. Indian J. Biochem. Biophy., 21: 130-132.
23. Kesari AN, Gupta RK, Singh SK, Diwakar S and Wata G (2006). Hypoglycemic and antihyperglycemic activity of Aegel marmelos seed extract in normal and diabetic rats. J. Ethnopharmacol., 107: 374-379.
24. Lowry OH, Rosenbrough NJ, Farr AL and Randall RJ (1951). Protein measurement with folin phenol reagent.J. Biol. Chem., 193: 265-275.
25. Mohan PV and Devi KS (1996). Cytotoxic potential of the preparations from Solanum trilobatum and the effect of Sobatum on tumor reduction in mice. Cancer Lett., 110: 71-76.
26. Mohan PV, Madhusudana Rao J, Sumathykutty MA and Devi KS (1998). Cytotoxicity of extracts of Solanum trilobatum and anticarcinogenic activity of Sobatum.Biomedicine, 18: 106-111.
27. Moore S and Stein WH (1948). Photometric method for use in the chromatography of amino acids. J. Biol.Chem., 176: 367-388.
28. Nagappa AN, Thakurdesai PA, Venkat Rao N and Jiwan Singh (2003). Antidiabetic activity of Terminalia catappa Linn fruits. J. Ethnopharmacol., 88: 45-50.
29. Odetola AA, Akinloye O, Egunjobi C, Adekunle WA and Ayoola AO (2006). Possible antidiabetic and antihyperlipidamic effect of fermented Parkia biglobosa (JACQ) extract in alloxan-induced diabetic rats. Clin. Exp. Pharmacol. Physiol., 33: 808-812.
30. Organization for Economic Co-operation Development (OECD) (2001). Guidance document on acute oral toxicity testing. Environment Directorate, OECD, Paris, pp.1-24.
31. Paglia D and Valentine W (1967). Studies on the quantitative and qualitative characterization of erythrocyte glutathione per oxidase. J. Laboratory and Clinical Med., 70: 158-169.
32. Pari L and Uma Maheswari J (2000). Antihyperglycaemic activity of Musa sapientum flowers: Effect on lipid per oxidation in alloxan diabetic rats. J. Ethnopharmacol., 14: 136-138.
33. Rajkumar L, Srinivasan N, Balasubramanian K and Govindarajulu P (1991). Increased degradation of dermal collagen in diabetic rats. Indian J. Exp. Bio., 29: 1081-1083.
34. Resmi CR, Aneez F, Sinilal B and Latha MS (2001).Antidiabetic effect of a herbal drug in alloxan diabetic rats. Indian Drugs, 38(6): 319-322.
35. Shahjahan M, Sabitha KE Mallika Jainu M and Shyamala Devi CS (2004). Effect of Solanum trilobatum against carbon tetrachloride induced hepatic damage in albino rats. Indian J. Med. Res., 120: 194-198.
36. Subramni J, Josekutty PC, Mehta AR and Bhatt PN (1989). Solasodine levels in Solanum sisymbriifolium Lam. Indian J. Exp. Biol., 27: 189.
37. Van Dam PS, Van Asbeck BS, Erkelens DW, Marx JJM, Gispen WH and Bravenboer B (1995). The role of oxidative stress in neuropathy and other diabetic complications. Diabetes Metab Res Rev, 11: 181-192.
38. Venkateswaran S and Pari L (2002). Effect of Coccinia indica on blood glucose, insulin and hepatic key enzymes in experimental diabetes. Pharmaceutical Biology, 40: 165-170.