HMSH2 and HMSH6 gene expression profiles in colorectal adenocarcinoma in patients up to 50 years of age

Biomedicine and Pharmacotherapy

Volumn 83, Issue , 2016, Pages 602-606

  Germini, Demétrius ^a   Gehrke, Flávia ^b,c   Lira, Daniel ^b   Alves, Beatriz ^b   Azzalis, Lígia ^d   Perez, Matheus ^b   Fonseca, Fernando ^b,d   Waisberg, Jaques ^a,b  

^a INSTITUTO DE ASSISTÊNCIA MÉDICA AO SERVIDOR PÚBLICO ESTADUAL   (Brazil)

^b FACULDADE DE MEDICINA DO ABC   (Brazil)

^c PAULISTA UNIVERSITY   (Brazil)

^d FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Colorectal adenocarcinoma; DNA mismatch repair; hMSH2; hMSH6: hereditary non polyposis colorectal cancer; Lynch syndrome

Indexed keywords

MUTS HOMOLOG 6; PROTEIN; PROTEIN MSH2; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; G-T MISMATCH-BINDING PROTEIN; MSH2 PROTEIN, HUMAN;

ADULT; ARTICLE; CANCER PATIENT; CLINICAL ARTICLE; FEMALE; GENE EXPRESSION PROFILING; GENE MUTATION; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE MICROARRAY; TUMOR INVASION; ADENOCARCINOMA; COLORECTAL TUMOR; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED;

ADENOCARCINOMA; ADULT; COLORECTAL NEOPLASMS; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; MUTS HOMOLOG 2 PROTEIN;

EID: 84989944505     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2016.07.015     Document Type: Article

References (29)

1. [1] Annie, Yu H.J., Lin, K.M., Ota, D.M., Lynch, H.T., Hereditary nonpolyposis colorectal cancer: preventive management. Cancer Treat. Rev. 29 (2003), 461–470.
2. [2] Lynch, H.T., Smyrk, T.C., Watson, P., Lanspa, S.J., Lynch, J.F., Lynch, P.M., Cavalieri, R.J., Boland, C.R., Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review. Gastroenterology 104 (1993), 1535–1549.
3. [3] Silva, F.C., Valentin, M.D., Ferreira, F.O., Carraro, D.M., Rossi, B.M., Mismatch repair genes in lynch syndrome: a review. Sao Paulo Med. J. 127 (2009), 46–51.
4. [4] Vasen, H.F., Watson, P., Mecklin, J.P., Lynch, H.T., New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, lynch syndrome) proposed by the international collaborative group on HNPCC. Gastroenterology 116 (1999), 1453–1456.
5. [5] Peltomaki, P., Vasen, H.F., Mutations predisposing to hereditary nonpolyposis colorectal cancer: database and results of a collaborative study. The international collaborative group on hereditary nonpolyposis colorectal cancer. Gastroenterology 113 (1997), 1146–1158.
6. [6] de la Chapelle, A., The incidence of lynch syndrome. Fam. Cancer 4 (2005), 233–237.
7. [7] Papp, J., Kovacs, M.E., Olah, E., Germline MLH1 and MSH2 mutational spectrum including frequent large genomic aberrations in hungarian hereditary non-polyposis colorectal cancer families: implications for genetic testing. World J. Gastroenterol. 13 (2007), 2727–2732.
8. [8] Iino, H., Simms, L., Young, J., Arnold, J., Winship, I.M., Webb, S.I., Furlong, K.L., Leggett, B., Jass, J.R., DNA microsatellite instability and mismatch repair protein loss in adenomas presenting in hereditary non-polyposis colorectal cancer. Gut 47 (2000), 37–42.
9. [9] Jass, J.R., Stewart, S.M., Stewart, J., Lane, M.R., Hereditary non-polyposis colorectal cancer-morphologies, genes and mutations. Mutat. Res. 310 (1994), 125–133.
10. [10] Pendergrass, C.J., Edelstein, D.L., Hylind, L.M., Phillips, B.T., Iacobuzio-Donahue, C., Romans, K., Griffin, C.A., Cruz-Correa, M., Tersmette, A.C., Offerhaus, G.J., Giardiello, F.M., Occurrence of colorectal adenomas in younger adults: an epidemiologic necropsy study. Clin. Gastroenterol. Hepatol. 6 (2008), 1011–1015.
11. [11] Rijcken, F.E., Hollema, H., Kleibeuker, J.H., Proximal adenomas in hereditary non-polyposis colorectal cancer are prone to rapid malignant transformation. Gut 50 (2002), 382–386.
12. [12] Walsh, M.D., Buchanan, D.D., Pearson, S.A., Clendenning, M., Jenkins, M.A., Win, A.K., Walters, R.J., Spring, K.J., Nagler, B., Pavluk, E., Arnold, S.T., Goldblatt, J., George, J., Suthers, G.K., Phillips, K., Hopper, J.L., Jass, J.R., Baron, J.A., Ahnen, D.J., Thibodeau, S.N., Lindor, N., Parry, S., Walker, N.I., Rosty, C., Young, J.P., Immunohistochemical testing of conventional adenomas for loss of expression of mismatch repair proteins in lynch syndrome mutation carriers: a case series from the australasian site of the colon cancer family registry. Mod. Pathol. 25 (2012), 722–730, 10.1038/modpathol.2011.
13. [13] Jascur, T., Boland, C.R., Structure and function of the components of the human DNA mismatch repair system. Int. J. Cancer 119 (2006), 2030–2035.
14. [14] Acharya, S., Wilson, T., Gradia, S., Kane, M.F., Guerrette, S., Marsischky, G.T., Kolodner, R., Fishel, R., HMSH2 forms specific mispair-binding complexes with HMSH3 and HMSH6. Proc. Natl. Acad. Sci. U. S. A. 93 (1996), 13629–13634.
15. [15] Koi, M., Umar, A., Chauhan, D.P., Cherian, S.P., Carethers, J.M., Kunkel, T.A., Boland, C.R., Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces n-methyl-n′-nitro-n-nitrosoguanidine tolerance in colon tumor cells with homozygous HMLH1 mutation. Cancer Res. 54 (1994), 4308–4312.
16. [16] Shia, J., Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome. Part I. The utility of immunohistochemistry. J. Mol. Diagn. 10 (2008), 293–300, 10.2353/jmoldx.2008.080031.
17. [17] Arzimanoglou, I., Gilbert, F., Barber, H.R., Microsatellite instability in human solid tumors. Cancer 82 (1998), 1808–1820.
18. [18] Mutter, G.L., Diagnosis of premalignant endometrial disease. J. Clin. Pathol. 55 (2002), 326–331.
19. [19] Hardisson, D., Moreno-Bueno, G., Sanchez, L., Sarrio, D., Suarez, A., Calero, F., Palacios, J., Tissue microarray immunohistochemical expression analysis of mismatch repair (HMLH1 and HMSH2 genes) in endometrial carcinoma and atypical endometrial hyperplasia: relationship with microsatellite instability. Mod. Pathol. 16 (2003), 1148–1158.
20. [20] Patricia, G.C., Pamela, O.D., Jorge, L.F.P., Aleksandra, V.L.S., Auro, D.G., Fernando, F.L.A., Chemotherapy induces genomic instability in oral mucosal cells of women with breast cancer. J. Solid Tumors, 2, 2012, 10.5430/jst.v2n2p10.
21. [21] Fernando, F.L.A., Aleksandra, V.L.S., Israel, B., Arias, V., Costa, L.J., Pinhal, A.A., del Giglio, A., Systemic chemotherapy induces microsatellite instability in the peripheral blood mononuclear cells of breast cancer patients. Breast Cancer Res. 7 (2005), R28–R32, 10.1186/bcr950.
22. [22] Hampel, H., Frankel, W.L., Martin, E., Arnold, M., Khanduja, K., Kuebler, P., Nakagawa, H., Sotamaa, K., Prior, T.W., Westman, J., Panescu, J., Fix, D., Lockman, J., Comeras, I., de la Chapelle, A., Screening for the lynch syndrome (hereditary nonpolyposis colorectal cancer). N. Engl. J. Med. 352 (2005), 1851–1860.
23. [23] Katballe, N., Christensen, M., Wikman, F.P., Orntoft, T.F., Laurberg, S., Frequency of hereditary non-polyposis colorectal cancer in danish colorectal cancer patients. Gut 50 (2002), 43–51.
24. [24] Martellucci, J., Civitelli, S., Dhamo, A., Tanzini, G., Familial colorectal cancer: a concept revisited. Colorectal Dis. 11 (2009), 133–137, 10.1111/j.1463-1318.2008.01561.x.
25. [25] Southey, M.C., Jenkins, M.A., Mead, L., Whitty, J., Trivett, M., Tesoriero, A.A., Smith, L.D., Jennings, K., Grubb, G., Royce, S.G., Walsh, M.D., Barker, M.A., Young, J.P., Jass, J.R., St John, D.J., Macrae, F.A., Giles, G.G., Hopper, J.L., Use of molecular tumor characteristics to prioritize mismatch repair gene testing in early-onset colorectal cancer. J. Clin. Oncol. 23 (2005), 6524–6532.
26. [26] O'Connell, J.B., Maggard, M.A., Livingston, E.H., Yo, C.K., Colorectal cancer in the young. Am. J. Surg. 187 (2004), 343–348.
27. [27] Koehler-Santos, P., Izetti, P., Abud, J., Pitroski, C.E., Cossio, S.L., Camey, S.A., Tarta, C., Damin, D.C., Contu, P.C., Rosito, M.A., Ashton-Prolla, P., Prolla, J.C., Identification of patients at-risk for lynch syndrome in a hospital-based colorectal surgery clinic. World J. Gastroenterol. 17 (2011), 766–773, 10.3748/wjg.v17.i6.766.
28. [28] Winawer, S., Fletcher, R., Rex, D., Bond, J., Burt, R., Ferrucci, J., Ganiats, T., Levin, T., Woolf, S., Johnson, D., Kirk, L., Litin, S., Simmang, C., Colorectal cancer screening and surveillance: clinical guidelines and rationale-update based on new evidence. Gastroenterology 124 (2003), 544–560.
29. [29] Casey, G., Lindor, N.M., Papadopoulos, N., Thibodeau, S.N., Moskow, J., Steelman, S., Buzin, C.H., Sommer, S.S., Collins, C.E., Butz, M., Aronson, M., Gallinger, S., Barker, M.A., Young, J.P., Jass, J.R., Hopper, J.L., Diep, A., Bapat, B., Salem, M., Seminara, D., Haile, R., Conversion analysis for mutation detection in mlh1 and msh2 in patients with colorectal cancer. JAMA 293 (2005), 799–809.