Nonischemic left ventricular scar and cardiac sudden death in the young

Human Pathology

Volumn 58, Issue , 2016, Pages 78-89

  di Gioia, Cira R T ^a   Giordano, Carla ^a   Cerbelli, Bruna ^a   Pisano, Annalinda ^a   Perli, Elena ^a   De Dominicis, Enrico ^b   Poscolieri, Barbara ^c   Palmieri, Vincenzo ^c   Ciallella, Costantino ^d   Zeppilli, Paolo ^c   d'Amati, Giulia ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c CATHOLIC UNIVERSITY   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

ARVC D; Cardiac sudden death; LDAC; Myocarditis; Nonischemic left ventricular scar

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; AUTOPSY; CARDIAC MUSCLE; CHILD; ECG ABNORMALITY; ELECTRIC POTENTIAL; FEMALE; GENETIC ANALYSIS; HEART LEFT VENTRICLE; HEART MUSCLE INJURY; HEART RIGHT VENTRICLE; HISTOLOGY; HUMAN; HUMAN TISSUE; INTERVENTRICULAR SEPTUM; JUVENILE; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; MICROSCOPY; MORPHOLOGY; NONISCHEMIC LEFT VENTRICULAR SCAR; PREVALENCE; QRS COMPLEX; SCAR; SCREENING; SUDDEN CARDIAC DEATH; YOUNG ADULT; AGE DISTRIBUTION; BIOPSY; CARDIOMYOPATHY; DEATH, SUDDEN, CARDIAC; DIFFERENTIAL DIAGNOSIS; DNA MUTATIONAL ANALYSIS; ELECTROCARDIOGRAPHY; GENETIC MARKER; GENETIC PREDISPOSITION; GENETICS; INFANT; ITALY; METABOLISM; MOLECULAR DIAGNOSIS; MORTALITY; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; PREDICTIVE VALUE; PRESCHOOL CHILD; RISK FACTOR;

GENETIC MARKER;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AUTOPSY; BIOPSY; CARDIOMYOPATHIES; CHILD; CHILD, PRESCHOOL; CICATRIX; DEATH, SUDDEN, CARDIAC; DIAGNOSIS, DIFFERENTIAL; DNA MUTATIONAL ANALYSIS; ELECTROCARDIOGRAPHY; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFANT; ITALY; MALE; MOLECULAR DIAGNOSTIC TECHNIQUES; MUTATION; MYOCARDIUM; PHENOTYPE; PREDICTIVE VALUE OF TESTS; PREVALENCE; RISK FACTORS; YOUNG ADULT;

EID: 84989929605     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2016.08.004     Document Type: Article

References (28)

1. [1] Mahrohldt, H, Wagner, A, Judd, MR, Sechtem, U, Kim, RJ, Delayed enhancement cardiovascular magnetic resonance assessment of non-ischaemic cardiomyopathies. Eur Heart J 15 (2005), 1461–1474.
2. [2] Marcu, CB, Nijveldt, R, Beek, AM, Van Rossum, AC, Delayed contrast enhancement magnetic resonance imaging for the assessment of cardiac disease. Heart Lung Circ 16 (2007), 70–78.
3. [3] Pilichou, K, Mancini, M, Rigato, I, et al. Nonischemic left ventricular scar: sporadic or familial? Screen the genes, scan the mutation carriers. Circulation 130 (2014), e180–e182.
4. [4] Maron, BJ, Towbin, JA, Thiene, G, et al. Contemporary definitions and classification of the cardiomyopathies: an American Heart Association scientific statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation 113 (2006), 1807–1816.
5. [5] Fontaine, G, Chen, HS, Arrhythmogenic right ventricular dysplasia back in force. Am J Cardiol 113 (2014), 1735–1739.
6. [6] Basso, C, Thiene, G, Corrado, D, Angelini, A, Nava, A, Valente, M, Arrhythmogenic right ventricular cardiomyopathy. Dysplasia, dystrophy, or myocarditis?. Circulation 94 (2006), 983–991.
7. [7] Vite, A, Gandjbakhch, E, Prost, C, et al. Desmosomal cadherins are decreased in explanted arrhythmogenic right ventricular dysplasia/cardiomyopathy patient hearts. PLoS One, 8, 2013, e75082.
8. [8] Sen-Chowdhry, S, Syrris, P, Prasad, SK, et al. Left-dominant arrhythmogenic cardiomyopathy: an under-recognized clinical entity. J Am Coll Cardiol 52 (2008), 2175–2187.
9. [9] d'Amati, G, De Caterina, R, Basso, C, Sudden cardiac death in an Italian competitive athlete: pre-participation screening and cardiovascular emergency care are both essential. Int J Cardiol 206 (2016), 84–86.
10. [10] Virmani, R, Burke, AP, Farb, A, Sudden cardiac death. Cardiovasc Pathol 10 (2001), 275–282.
11. [11] Basso, C, Burke, M, Fornes, P, et al. Guidelines for autopsy investigation of sudden cardiac death. Virchows Arch 452 (2008), 11–18.
12. [12] Leone, O, Veinot, JP, Angelini, A, et al. 2011 consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology. Cardiovasc Pathol 21 (2012), 245–274.
13. [13] Pilichou, K, Nava, A, Basso, C, et al. Mutations in desmoglein-2 gene are associated with arrhythmogenic right ventricular cardiomyopathy. Circulation 113 (2006), 1171–1179.
14. [14] Rampazzo, A, Nava, A, Malacrida, S, et al. Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy. Am J Hum Genet 71 (2002), 1200–1206.
15. [15] Leone, O, Rapezzi, C, Sinagra, G, et al. Consensus document on endomyocardial biopsy of the Associazione per la Patologia Cardiovascolare Italiana. G Ital Cardiol 10:9 Suppl. 1 (2009), 3S–50S.
16. [16] Basso, C, Corrado, D, Thiene, G, Cardiovascular causes of sudden death in young individuals including athletes. Cardiol Rev 7 (1999), 127–135.
17. [17] Maron, BJ, Doerer, JJ, Haas, TS, Tierney, DM, Mueller, FO, Sudden deaths in young competitive athletes: analysis of 1866 deaths in the United States, 1980-2006. Circulation 119 (2009), 1085–1092.
18. [18] Sheppard, MN, Aetiology of sudden cardiac death in sport: a histopathologist's perspective. Br J Sports Med 46 (2012), i15–i21.
19. [19] Corrado, D, Thiene, G, Nava, A, Rossi, L, Pennelli, N, Sudden death in young competitive athletes: clinicopathologic correlations in 22 cases. Am J Med 89 (1990), 588–596.
20. [20] Corrado, D, Basso, C, Rizzoli, G, Schiavon, M, Thiene, G, Does sports activity enhance the risk of sudden death in adolescents and young adults?. J Am Coll Cardiol 42 (2003), 1959–1963.
21. [21] Tavora, F, Zhang, M, Franco, M, et al. Distribution of biventricular disease in arrhythmogenic cardiomyopathy: an autopsy study. HUM PATHOL 43 (2012), 592–596.
22. [22] Kodikara, S, Left-sided ventricular cardiomyopathy with minimal right ventricular involvement. Med Sci Law 52 (2012), 116–118.
23. [23] John, BT, Tamarappoo, BK, Titus, JL, Edwards, WD, Shen, WK, Chugh, SS, Global remodeling of the ventricular interstitium in idiopathic myocardial fibrosis and sudden cardiac death. Heart Rhythm 1 (2004), 141–149.
24. [24] Pilichou, K, Remme, CA, Basso, C, et al. Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy. J Exp Med 206 (2009), 1787–1802.
25. [25] Campian, ME, Verberne, HJ, Hardziyenka, M, et al. Assessment of inflammation in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia. Eur J Nucl Med Mol Imaging 37 (2010), 2079–2085.
26. [26] Madias, JE, Low QRS voltage and its causes. J Electrocardiol 41 (2008), 498–500.
27. [27] Corrado, D, Pelliccia, A, Heidbuchel, H, et al. Recommendations for interpretation of 12-lead electrocardiogram in the athlete. Eur Heart J 31 (2010), 243–259.
28. [28] Zorzi, A, Perazzolo Marra, M, et al. Nonischemic left ventricular scar as a substrate of life-threatening ventricular arrhythmias and sudden cardiac death in competitive athletes. Circ Arrhythm Electrophysiol, 9, 2016, e004229.