Serum concentrations of TNF-αs soluble receptors during psychotherapy in German soldiers suffering from combat-related PTSD

Psychiatria Danubina

Volumn 28, Issue 3, 2016, Pages 293-298

  Himmerich, Hubertus ^a,b   Willmund, Gerd D ^a   Zimmermann, Peter ^a   Wolf, Jörg Egbert ^a   Bühler, Antje H ^a   Kirkby, Kenneth C ^c   Dalton, Bethan ^b   Holdt, Lesca M ^d   Teupser, Daniel ^d   Wesemann, Ulrich ^a  

^a Bundeswehr Hospital   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF TASMANIA   (Australia)

^d UNIVERSITY OF MUNICH   (Germany)

Author keywords

Cytokines; Post traumatic stress disorder; Psychotherapy; Soluble TNF receptors; Tumor necrosis factor (TNF )

Indexed keywords

TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR P55; TUMOR NECROSIS FACTOR RECEPTOR P75; UNCLASSIFIED DRUG; ANTIDEPRESSANT AGENT; MATERIA MEDICA; TUMOR NECROSIS FACTOR RECEPTOR 1;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; EYE MOVEMENT DESENSITIZATION AND REPROCESSING; HUMAN; LONGITUDINAL STUDY; MALE; POSTTRAUMATIC STRESS DIAGNOSTIC SCALE; POSTTRAUMATIC STRESS DISORDER; PROTEIN BLOOD LEVEL; PSYCHOLOGICAL RATING SCALE; RANDOMIZED CONTROLLED TRIAL; SOLDIER; AMBULATORY CARE; BLOOD; COMBAT DISORDERS; COMPARATIVE STUDY; HOSPITAL ADMISSION; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; PSYCHOLOGY; PSYCHOTHERAPY; STRESS DISORDERS, POST-TRAUMATIC;

ADULT; AMBULATORY CARE; ANTIDEPRESSIVE AGENTS; COMBAT DISORDERS; COMBINED MODALITY THERAPY; CROSS-SECTIONAL STUDIES; HUMANS; LONGITUDINAL STUDIES; MALE; MATERIA MEDICA; MIDDLE AGED; MILITARY PERSONNEL; PATIENT ADMISSION; PSYCHOTHERAPY; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; STRESS DISORDERS, POST-TRAUMATIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84989927214     PISSN: 03535053     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Berthold-Losleben M & Himmerich H: The TNF-alpha system: functional aspects in depression, narcolepsy and psychopharmacology. Curr Neuropharmacol 2008; 6:193-202.
2. Borovcanin M, Jovanovic I, Radosavljevic G, Djukic Dejanovic S, Bankovic D, Arsenijevic N et al.: Elevated serum level of type-2 cytokine and low IL-17 in first episode psychosis and schizophrenia in relapse. J Psychiatr Res 2012; 46:1421-6.
3. Borovcanin M, Jovanovic I, Radosavljevic G, Djukic Dejanovic S, Stefanovic V, Arsenijevic N et al.: Antipsychotics can modulate the cytokine profile in schizophrenia: attenuation of the type-2 inflammatory response. Schizophr Res 2013; 147: 103-109.
4. Carswell EA, Old LJ, Kassel RL, Green S, Fiore N & Williamson B: An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci USA 1975; 72:3666-70.
5. Chen T, Guo M, Gao Y, Chen F, Guo J, Liu T et al.: A comparative study on the levels of serum cytokines and cortisol among post-traumatic stress disorder patients of Li and Han ethnicities in Hainan. Chin Med J 2014; 127:2771-4.
6. Del Grande da Silva G, Wiener CD, Barbosa LP, Gonçalves Araujo JM, Molina ML, San Martin P et al.: Pro-inflammatory cytokines and psychotherapy in depression: Results from a randomized clinical trial. J Psychiatr Res 2016; 75:57-64.
7. De Quervain DJ, Aerni A, Schelling G & Roozendaal B: Glucocorticoids and the regulation of memory in health and disease. Front Neuroendocrinol 2009; 30:358-70 8.
8. De Quervain DJ, Bentz D, Michael T, Bolt OC, Wiederhold BK, Margraf J et al.: Glucocorticoids enhance extinction-based psychotherapy. Proc Natl Acad Sci USA 2011; 108:6621-5.
9. Efendov AA, Sellbom M & Bagby RM: The utility and comparative incremental validity of the MMPI-2 and Trauma Symptom Inventory validity scales in the detection of feigned PTSD. Psychol Assess 2008; 20:317-26.
10. Foa EB: Posttraumatic Stress Diagnostic Scale Manual. National Computer Systems Inc, 1995.
11. Ghezzi P & Cerami A: Tumor necrosis factor as a pharmacological target. Mol. Biotechnol 2005; 31:239-44.
12. Himmerich H, Koethe D, Schuld A, Yassouridis A & Pollmächer T: Plasma levels of leptin and endogenous immune modulators during treatment with carbamazepine or lithium. Psychopharmacology 2005; 179:447-51.
13. Himmerich H, Fulda S, Linseisen J, Seiler H, Wolfram G, Himmerich S et al.: Depression, comorbidities and the TNF-alpha system. Eur Psychiatry 2008; 23:421-9.
14. Himmerich H, Schönherr J, Fulda S, Sheldrick AJ, Bauer K & Sack U: Impact of antipsychotics on cytokine production in-vitro. J Psychiatr Res 2011; 45:1358-65.
15. Himmerich H, Bartsch S, Hamer H, Mergl R, Schönherr J, Petersein C et al.: Impact of mood stabilizers and antiepileptic drugs on cytokine production in-vitro. J Psychiatr Res 2013; 47:1751-9.
16. Himmerich H, Willmund GD, Zimmermann P, Wolf JE, Bühler AH, Holdt LM et al.: Serum concentrations of TNF-α, sTNF-R p55 and p75 and post-traumatic stress in German soldiers. Eur Cytokine Netw 2015; 26:57-60.
17. Himmerich H, Wolf JE, Zimmermann P, Bühler AH, Holdt LM, Teupser D et al.: Serum Concentrations of Tumor Necrosis Factor-α and its Soluble Receptors in Soldiers with and Without Combat-related Posttraumatic Stress Disorder: Influence of Age and Body Mass Index. Chin Med J 2016; 129:751-2.
18. Jergović M, Bendelja K, Savić Mlakar A, Vojvoda V, Aberle N, Jovanovic T et al.: Circulating levels of hormones, lipids, and immune mediators in post-traumatic stress disorder - a 3-month follow-up study. Front Psychiatry 2015; 6:49.
19. Kluge M, Schuld A, Schacht A, Himmerich H, Dalal MA, Wehmeier PM et al.: Effects of clozapine and olanzapine on cytokine systems are closely linked to weight gain and druginduced fever. Psychoneuroendocrinology 2009; 34:118-28.
20. Koh KB, Lee Y, Beyn KM, Chu SH & Kim DM: Counterstress effects of relaxation on proinflammatory and antiinflammatory cytokines. Brain Behav Immun 2008; 22:1130-7.
21. Kraus T, Haack M, Schuld A, Hinze-Selch D, Koethe D & Pollmächer T: Body weight, the tumor necrosis factor system, and leptin production during treatment with mirtazapine or venlafaxine. Pharmacopsychiatry 2002; 35:220-5.
22. Krügel U, Fischer J, Bauer K, Sack U & Himmerich H: The impact of social isolation on immunological parameters in rats. Arch Toxicol 2014; 88:853-5.
23. Lass-Hennemann J & Michael T: Endogenous cortisol levels influence exposure therapy in spider phobia. Behav Res Ther 2014; 60:39-45.
24. Lindqvist D, Wolkowitz OM, Mellon S, Yehuda R, Flory JD, Henn-Haase C et al.: Proinflammatory milieu in combat-related PTSD is independent of depression and early life stress. Brain Behav Immun 2014; 42:81-8.
25. Maes M, Song C & Yirmiya R: Targeting IL-1 in depression. Expert Opin Ther Targets 2012; 16:1097-112.
26. McCarthy S: Posttraumatic Stress Diagnostic Scale (PDS). Occup Med 2008; 58:379.
27. Miller AH, Haroon E, Raison CL & Felger JC: Cytokine targets in the brain: impact on neurotransmitters and neurocircuits. Depress Anxiety 2013; 30:297-306.
28. Moreira FP, Cardoso Tde A, Mondin TC, Souza LD, Silva R, Jansen K et al.: The effect of proinflammatory cytokines in Cognitive Behavioral Therapy. J Neuroimmunol 2015; 285:143-6.
29. Müller N, Weidinger E, Leitner B & Schwarz MJ: The role of inflammation in schizophrenia. Front Neurosci 2015; 9:372.
30. Munzer A, Sack U, Mergl R, Schönherr J, Petersein C, Bartsch S et al.: Impact of antidepressants on cytokine production of depressed patients in vitro. Toxins 2013; 5:2227-40.
31. Pandey GN, Ren X, Rizavi HS & Zhang H: Proinflammatory cytokines and their membrane-bound receptors are altered in the lymphocytes of schizophrenia patients. Schizophr Res 2015; 164:193-8.
32. Petersein C, Sack U, Mergl R, Schönherr J, Schmidt FM, Lichtblau N et al.: Impact of lithium alone and in combination with antidepressants on cytokine production in vitro. J Neural Transm 2015; 122:109-22.
33. Rotter A, Biermann T, Stark C, Decker A, Demling J, Zimmermann R et al.: Changes of cytokine profiles during electroconvulsive therapy in patients with major depression. J ECT 2013; 29:162-9.
34. Schmidt FM, Lichtblau N, Minkwitz J, Chittka T, Thormann J, Kirkby KC et al.: Cytokine levels in depressed and non-depressed subjects, and masking effects of obesity. J Psychiatr Res 2014; 55:29-34.
35. Schumacher S, Gaudlitz K, Plag J, Miller R, Kirschbaum C, Fehm L et al.: Who is stressed? A pilot study of salivary cortisol and alpha-amylase concentrations in agoraphobic patients and their novice therapists undergoing in vivo exposure. Psychoneuroendocrinology. 2014;49:280-9 36.
36. Vocks S, Legenbauer T, Wächter A, Wucherer M & Kosfelder J: What happens in the course of body exposure? Emotional, cognitive, and physiological reactions to mirror confrontation in eating disorders. J Psychosom Res 2007; 62:231-9.