Pharmacological and psychosocial treatment of depression in primary care: Low intensity and poor adherence and continuity

Journal of Affective Disorders

Volumn 202, Issue , 2016, Pages 145-152

  Vuorilehto, Maria S ^a,b   Melartin, Tarja K ^a,b   Riihimäki, Kirsi ^a,c   Isometsä, Erkki T ^a,b  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c Health Care and Social Services   (Finland)

Author keywords

Adherence; Antidepressants; Depression; Follow up; Outcome; Primary care; Psychosocial support; Treatment

Indexed keywords

ANTIDEPRESSANT AGENT; MONOAMINE OXIDASE INHIBITOR; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; TETRACYCLIC ANTIDEPRESSANT AGENT; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; ARTICLE; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; HUMAN; INTERVIEW; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MEDICATION COMPLIANCE; MENTAL HEALTH SERVICE; PATIENT ATTITUDE; PATIENT COMPLIANCE; PATIENT REFERRAL; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; PSYCHOSOCIAL CARE; REMISSION; STRUCTURED CLINICAL INTERVIEW FOR DSM DISORDERS; UNSPECIFIED SIDE EFFECT; ATTITUDE TO HEALTH; DEPRESSION; DEPRESSIVE DISORDER, MAJOR; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FINLAND; LONGITUDINAL STUDY; MIDDLE AGED; ORGANIZATION AND MANAGEMENT; PRIMARY HEALTH CARE; PROCEDURES; PSYCHOTHERAPY; STATISTICS AND NUMERICAL DATA;

ADULT; ANTIDEPRESSIVE AGENTS; ATTITUDE TO HEALTH; DEPRESSION; DEPRESSIVE DISORDER, MAJOR; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; FINLAND; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PATIENT COMPLIANCE; PRIMARY HEALTH CARE; PSYCHOTHERAPY;

EID: 84989925712     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2016.05.035     Document Type: Article

References (75)

1. American Psychiatric Association (APA), 2010. Practice Guideline for the Treatment of Patients with Major Depressive Disorder. psychiatryonline. org.
2. Andrews, G., Cuijpers, P., Craske, M.G., McEvoy, P., Titov, N., Computer therapy for the anxiety and depressive disorders is effective, acceptable and practical health care: a meta-analysis. PLoS One, 5, 2010, e13196.
3. Bambauer, K.Z., Soumerai, S.B., Adams, A.S., Zhang, F., Ross-Degnan, D., Provider and patient characteristics associated with antidepressant nonadherence: the impact of provider specialty. J. Clin. Psychiatry 68 (2007), 867–873.
4. Beck, A.T., Ward, C., Mendelson, M., Mock, J., Erbaugh, J., An inventory for measuring depression. Arch. Gen. Psychiatry 4 (1961), 561–571.
5. Beck, A.T., Epstein, N., Brown, G., Steer, R.A., An inventory for measuring clinical anxiety: psychometric properties. J. Consult. Clin. Psychol. 56 (1988), 893–897.
6. Bee, P.E., Bower, P., Lovell, K., Gilbody, S., Richards, D., Gask, L., Roach, P., Psychotherapy mediated by remote communication technologies: a meta-analytic review. BMC Psychiatry 8 (2008), 60–244X-8–60.
7. Blumenthal, J.A., Burg, M.M., Barefoot, J., Williams, R.B., Haney, T., Zimet, G., Social support, type A behavior, and coronary artery disease. Psychosom. Med. 49 (1987), 331–340.
8. Bower, P., Richards, D., Lovell, K., The clinical and cost-effectiveness of self-help treatments for anxiety and depressive disorders in primary care: a systematic review. Br. J. Gen. Pract. 51 (2001), 838–845.
9. Bull, S.A., Hu, X.H., Hunkeler, E.M., Lee, J.Y., Ming, E.E., Markson, L.E., Fireman, B., Discontinuation of use and switching of antidepressants: influence of patient-physician communication. J. Am. Med. Assoc. 288 (2002), 1403–1409.
10. Chong, W.W., Aslani, P., Chen, T.F., Effectiveness of interventions to improve antidepressant medication adherence: a systematic review. Int. J. Clin. Pract. 65 (2011), 954–975.
11. Clark, D.M., Implementing NICE guidelines for the psychological treatment of depression and anxiety disorders: the IAPT experience. Int. Rev. Psychiatry 23 (2011), 318–327.
12. Cleare, A., Pariante, C.M., Young, A.H., Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association. J. Psychopharmacol. (Oxf. Engl.) 29 (2015), 459–525.
13. Coventry, P.A., Hudson, J.L., Kontopantelis, E., Archer, J., Richards, D.A., Gilbody, S., Lovell, K., Dickens, C., Gask, L., Waheed, W., Bower, P., Characteristics of effective collaborative care for treatment of depression: a systematic review and meta-regression of 74 randomised controlled trials. PLoS One, 9, 2014, e108114.
14. Coyne, J.C., Klinkman, M.S., Gallo, S.M., Schwenk, T.L., Short-term outcomes of detected and undetected depressed primary care patients and depressed psychiatric patients. Gen. Hosp. Psychiatry 19 (1997), 333–343.
15. Cuijpers, P., van Straten, A., van Oppen, P., Andersson, G., Are psychological and pharmacologic interventions equally effective in the treatment of adult depressive disorders? A meta-analysis of comparative studies. J. Clin. Psychiatry, 2008, 1839–1841.
16. Cuijpers, P., van Straten, A., van Schaik, A., Andersson, G., Psychological treatment of depression in primary care: a meta-analysis. Br. J. Gen. Pract. 59 (2009), e51–e60.
17. Cuijpers, P., Andersson, G., Donker, T., van Straten, A., Psychological treatment of depression: results of a series of meta-analyses. Nord. J. Psychiatry 65 (2011), 354–364.
18. Demyttenaere, K., Risk factors and predictors of compliance in depression. Eur. Neuropsychopharmacol. 13:Suppl 3 (2003), S69–S75.
19. Edlund, M.J., Fortney, J.C., Reaves, C.M., Pyne, J.M., Mittal, D., Beliefs about depression and depression treatment among depressed veterans. Med. Care 46 (2008), 581–589.
20. M.B., First, M., Gibbon, R.L., Spitzer, J.B.W., Williams, L.S., Benjamin, 1997. Structured Clinical Interview for DSM-IV Axis II Personality Disorders, (SCID-II).
21. M.B., First, R.L., Spitzer, M., Gibbon, J.B.W., Williams, 2002. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition with Psychotic Screen.
22. Firth, N., Barkham, M., Kellett, S., The clinical effectiveness of stepped care systems for depression in working age adults: a systematic review. J. Affect. Disord. 170 (2015), 119–130.
23. Gabilondo, A., Rojas-Farreras, S., Rodriguez, A., Fernandez, A., Pinto-Meza, A., Vilagut, G., Haro, J.M., Alonso, J., Use of primary and specialized mental health care for a major depressive episode in Spain by ESEMeD respondents. Psychiatr. Serv. 62 (2011), 152–161.
24. Gilchrist, G., Gunn, J., Observational studies of depression in primary care: what do we know?. BMC Fam. Pract., 8, 2007, 28.
25. Goldman, H.H., Skodol, A.E., Lave, T.R., Revising axis V for DSM-IV: a review of measures of social functioning. Am. J. Psychiatry 149 (1992), 1148–1156.
26. Gusmao, R., Quintao, S., McDaid, D., Arensman, E., Van Audenhove, C., Coffey, C., Varnik, A., Varnik, P., Coyne, J., Hegerl, U., Antidepressant utilization and suicide in europe: an ecological multi-national study. PLoS One, 8, 2013, e66455.
27. Hamalainen, J., Isometsa, E., Laukkala, T., Kaprio, J., Poikolainen, K., Heikkinen, M., Lindeman, S., Aro, H., Use of health services for major depressive episode in Finland. J. Affect. Disord. 79 (2004), 105–112.
28. Hamalainen, J., Isometsa, E., Sihvo, S., Kiviruusu, O., Pirkola, S., Lonnqvist, J., Treatment of major depressive disorder in the Finnish general population. Depress Anxiety 26 (2009), 1049–1059.
29. Hamilton, M., A rating scale for depression. J. Neurol. Neurosurg. Psychiatry 23 (1960), 56–62.
30. Hunot, V.M., Horne, R., Leese, M.N., Churchill, R.C., A cohort study of adherence to antidepressants in primary care: the influence of antidepressant concerns and treatment preferences. Prim. Care Companion J. Clin. Psychiatry 9 (2007), 91–99.
31. Johnson, J.G., Cohen, P., Kasen, S., Brook, J.S., Personality disorder traits associated with risk for unipolar depression during middle adulthood. Psychiatry Res. 136 (2005), 113–121.
32. Katon, W., Von Korff, M., Lin, E., Walker, E., Simon, G.E., Bush, T., Robinson, P., Russo, J., Collaborative management to achieve treatment guidelines. Impact on depression in primary care. J. Am. Med. Assoc. 273 (1995), 1026–1031.
33. Katon, W., Robinson, P., Von Korff, M., Lin, E., Bush, T., Ludman, E., Simon, G., Walker, E., A multifaceted intervention to improve treatment of depression in primary care. Arch. Gen. Psychiatry 53 (1996), 924–932.
34. Kennedy, S.H., Lam, R.W., Parikh, S.V., Patten, S.B., Ravindran, A.V., Canadian Canadian Network for Mood and Anxiety Treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults. Introduction. J. Affect. Disord. 117:Suppl 1 (2009), S1–S2.
35. Kessler, R.C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K.R., Rush, A.J., Walters, E.E., Wang, P.S., National Comorbidity Survey Replication, The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). J. Am. Med. Assoc. 289 (2003), 3095–3105.
36. Klinkman, M.S., Bauroth, S., Fedewa, S., Kerber, K., Kuebler, J., Adman, T., Sen, A., Long-term clinical outcomes of care management for chronically depressed primary care patients: a report from the depression in primary care project. Ann. Fam. Med. 8 (2010), 387–396.
37. Leitlinien, N., 2015. S3-Guideline/NVL Unipolar Depression.
38. Limosin, F., Loze, J.Y., Zylberman-Bouhassira, M., Schmidt, M.E., Perrin, E., Rouillon, F., The course of depressive illness in general practice. Can. J. Psychiatry 49 (2004), 119–123.
39. Lin, E.H., Von Korff, M., Katon, W., Bush, T., Simon, G.E., Walker, E., Robinson, P., The role of the primary care physician in patients’ adherence to antidepressant therapy. Med. Care 33 (1995), 67–74.
40. Lin, E.H., Katon, W.J., Simon, G.E., Von Korff, M., Bush, T.M., Walker, E.A., Unutzer, J., Ludman, E.J., Low-intensity treatment of depression in primary care: is it problematic?. Gen. Hosp. Psychiatry 22 (2000), 78–83.
41. Lynch, J., Moore, M., Moss-Morris, R., Kendrick, T., Are patient beliefs important in determining adherence to treatment and outcome for depression? Development of the beliefs about depression questionnaire. J. Affect. Disord. 133 (2011), 29–41.
42. Maddox, J.C., Levi, M., Thompson, C., The compliance with antidepressants in general practice. J. Psychopharmacol. 8 (1994), 48–52.
43. Mattisson, C., Bogren, M., Horstmann, V., Tambs, K., Munk-Jorgensen, P., Nettelbladt, P., Risk factors for depressive disorders in the Lundby cohort—a 50 year prospective clinical follow-up. J. Affect. Disord. 113 (2009), 203–215.
44. Melartin, T.K., Rytsala, H.J., Leskela, U.S., Lestela-Mielonen, P.S., Sokero, T.P., Isometsa, E.T., Severity and comorbidity predict episode duration and recurrence of DSM-IV major depressive disorder. J. Clin. Psychiatry 65 (2004), 810–819.
45. Melartin, T.K., Rytsala, H.J., Leskela, U.S., Lestela-Mielonen, P.S., Sokero, T.P., Isometsa, E.T., Continuity is the main challenge in treating major depressive disorder in psychiatric care. J. Clin. Psychiatry 66 (2005), 220–227.
46. Morey, E., Thacher, J.A., Craighead, W.E., Patient preferences for depression treatment programs and willingness to pay for treatment. J. Ment. Health Policy Econ. 10 (2007), 73–85.
47. National Board of Health and Welfare, 2010. National Guidelines for Care in cases of Depression and Anxiety Disorders. 2010.
48. NICE, 2010. Depression: The NICE Guideline on the Treatment and Management of Depression In Adults (Updated edition).
49. Nutting, P.A., Rost, K., Dickinson, M., Werner, J.J., Dickinson, P., Smith, J.L., Gallovic, B., Barriers to initiating depression treatment in primary care practice. J. Gen. Intern. Med. 17 (2002), 103–111.
50. Raue, P.J., Schulberg, H.C., Heo, M., Klimstra, S., Bruce, M.L., Patients’ depression treatment preferences and initiation, adherence, and outcome: a randomized primary care study. Psychiatr. Serv. 60 (2009), 337–343.
51. Richards, D.A., Borglin, G., Implementation of psychological therapies for anxiety and depression in routine practice: two year prospective cohort study. J. Affect. Disord. 133 (2011), 51–60.
52. Ronalds, C., Creed, F., Stone, K., Webb, S., Tomenson, B., Outcome of anxiety and depressive disorders in primary care. Br. J. Psychiatry 171 (1997), 427–433.
53. Rost, K., Williams, C., Wherry, J., Smith, G.R. Jr, The process and outcomes of care for major depression in rural family practice settings. J. Rural Health 11 (1995), 114–121.
54. Rost, K., Zhang, M., Fortney, J., Smith, J., Coyne, J., Smith, G.R. Jr, Persistently poor outcomes of undetected major depression in primary care. Gen. Hosp. Psychiatry 20 (1998), 12–20.
55. Sighinolfi, C., Nespeca, C., Menchetti, M., Levantesi, P., Belvederi Murri, M., Berardi, D., Collaborative care for depression in European countries: a systematic review and meta-analysis. J. Psychosom. Res. 77 (2014), 247–263.
56. Sikorski, C., Luppa, M., Konig, H.H., van den Bussche, H., Riedel-Heller, S.G., Does GP training in depression care affect patient outcome? - A systematic review and meta-analysis. BMC Health Serv. Res. 12 (2012), 10–6963–12-10.
57. Simon, G.E., VonKorff, M., Wagner, E.H., Barlow, W., Patterns of antidepressant use in community practice. Gen. Hosp. Psychiatry 15 (1993), 399–408.
58. Simon, G.E., Von Korff, M., Rutter, C.M., Peterson, D.A., Treatment process and outcomes for managed care patients receiving new antidepressant prescriptions from psychiatrists and primary care physicians. Arch. Gen. Psychiatry 58 (2001), 395–401.
59. Simon, G.E., Fleck, M., Lucas, R., Bushnell, D.M., (LIDO Group), Prevalence and predictors of depression treatment in an international primary care study. Am. J. Psychiatry 161 (2004), 1626–1634.
60. Spitzer, R.L., Williams, J.B., Kroenke, K., Linzer, M., deGruy, F.V. 3rd, Hahn, S.R., Brody, D., Johnson, J.G., Utility of a new procedure for diagnosing mental disorders in primary care. The PRIME-MD 1000 study. J. Am. Med. Assoc. 272 (1994), 1749–1756.
61. The Finnish Medical Society Duodecim and Finnish Psychiatric Association, 2014. Current Care Guideline (Käypä hoito -suositus): Depressio. Suomalaisen Lääkäriseuran Duodecimin ja Suomen Psykiatriyhdistys Ry:n asettama työryhmä.
62. Thombs, B.D., Coyne, J.C., Cuijpers, P., de Jonge, P., Gilbody, S., Ioannidis, J.P., Johnson, B.T., Patten, S.B., Turner, E.H., Ziegelstein, R.C., Rethinking recommendations for screening for depression in primary care. Can. Med. Assoc. J. 184 (2012), 413–418.
63. Thompson, C., Kinmonth, A.L., Stevens, L., Peveler, R.C., Stevens, A., Ostler, K.J., Pickering, R.M., Baker, N.G., Henson, A., Preece, J., Cooper, D., Campbell, M.J., Effects of a clinical-practice guideline and practice-based education on detection and outcome of depression in primary care: Hampshire Depression Project randomised controlled trial. Lancet 355 (2000), 185–191.
64. Thompson, C., Peveler, R.C., Stephenson, D., McKendrick, J., Compliance with antidepressant medication in the treatment of major depressive disorder in primary care: a randomized comparison of fluoxetine and a tricyclic antidepressant. Am. J. Psychiatry 157 (2000), 338–343.
65. Thompson, C., Ostler, K., Peveler, R.C., Baker, N., Kinmonth, A.L., Dimensional perspective on the recognition of depressive symptoms in primary care: The Hampshire Depression Project 3. Br. J. Psychiatry 179 (2001), 317–323.
66. Thota, A.B., Sipe, T.A., Byard, G.J., Zometa, C.S., Hahn, R.A., McKnight-Eily, L.R., Chapman, D.P., Abraido-Lanza, A.F., Pearson, J.L., Anderson, C.W., Gelenberg, A.J., Hennessy, K.D., Duffy, F.F., Vernon-Smiley, M.E., Nease, D.E. Jr, Williams, S.P., Community Preventive Services Task Force. Collaborative care to improve the management of depressive disorders: a community guide systematic review and meta-analysis. Am. J. Prev. Med. 42 (2012), 525–538.
67. van Schaik, D.J., Klijn, A.F., van Hout, H.P., van Marwijk, H.W., Beekman, A.T., de Haan, M., van Dyck, R., Patients’ preferences in the treatment of depressive disorder in primary care. Gen. Hosp. Psychiatry 26 (2004), 184–189.
68. Van Voorhees, B.W., Cooper, L.A., Rost, K.M., Nutting, P., Rubenstein, L.V., Meredith, L., Wang, N.Y., Ford, D.E., Primary care patients with depression are less accepting of treatment than those seen by mental health specialists. J. Gen. Intern. Med. 18 (2003), 991–1000.
69. Van Voorhees, B.W., Fogel, J., Houston, T.K., Cooper, L.A., Wang, N.Y., Ford, D.E., Beliefs and attitudes associated with the intention to not accept the diagnosis of depression among young adults. Ann. Fam. Med. 3 (2005), 38–46.
70. Vuorilehto, M., Melartin, T., Isometsa, E., Depressive disorders in primary care: recurrent, chronic, and co-morbid. Psychol. Med. 35 (2005), 673–682.
71. Vuorilehto, M.S., Melartin, T.K., Rytsala, H.J., Isometsa, E.T., Do characteristics of patients with major depressive disorder differ between primary and psychiatric care?. Psychol. Med. 37 (2007), 893–904.
72. Vuorilehto, M.S., Melartin, T.K., Isometsa, E.T., Course and outcome of depressive disorders in primary care: a prospective 18-month study. Psychol. Med. 39 (2009), 1697–1707.
73. Wang, P.S., Lane, M., Olfson, M., Pincus, H.A., Wells, K.B., Kessler, R.C., Twelve-month use of mental health services in the United States: results from the National Comorbidity Survey Replication. Arch. Gen. Psychiatry 62 (2005), 629–640.
74. Wells, K.B., Sherbourne, C.D., Functioning and utility for current health of patients with depression or chronic medical conditions in managed, primary care practices. Arch. Gen. Psychiatry 56 (1999), 897–904.
75. Wittchen, H.U., Jacobi, F., Rehm, J., Gustavsson, A., Svensson, M., Jonsson, B., Olesen, J., Allgulander, C., Alonso, J., Faravelli, C., Fratiglioni, L., Jennum, P., Lieb, R., Maercker, A., van Os, J., Preisig, M., Salvador-Carulla, L., Simon, R., Steinhausen, H.C., The size and burden of mental disorders and other disorders of the brain in Europe 2010. Eur. Neuropsychopharmacol. 21 (2011), 655–679.