Comparison between pioglitazone and metformin in terms of efficacy in patients with polycystic ovarian syndrome

Pakistan Journal of Medical and Health Sciences

Volumn 10, Issue 2, 2016, Pages 574-577

  Chaudhry, Iram ^a   Sadaf Un Nisa, ^a   Shams Un Nisa, ^b  

^a QAMC   (Pakistan)

^b AMC   (Pakistan)

Author keywords

Metformin; Ovaries; Ovulation; Pioglitazone; Polycystic

Indexed keywords

METFORMIN; PIOGLITAZONE;

ADULT; AGE DISTRIBUTION; ARTICLE; BODY MASS; CONTROLLED STUDY; DISEASE DURATION; DRUG EFFICACY; EVIDENCE BASED PRACTICE; FEMALE; FEMALE FERTILITY; HUMAN; MAJOR CLINICAL STUDY; MARRIAGE; MARRIAGE DURATION; OBESITY; OVARY POLYCYSTIC DISEASE; OVULATION INDUCTION; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION;

EID: 84989817604     PISSN: 19967195     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Teede H, Deeks A, Moran L. Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Med. 2010;8:41
2. Saad AK. Polycystic ovary syndrome: diagnosis and management of related infertility. ObsGynReprod Med. 2009;19(10):263-70
3. Turner KA. Polycystic ovary syndrome: update on treatment options and treatment considerations for the future.Clin Med Insights Womens Health.2011:467-81
4. Vause TD, Cheung AP, Sierra S, Claman P, Graham J, Guillemin JA, et al. Ovulation induction in polycystic ovary syndrome. J ObstetGynaecol Can. 2010;32(5):495-502
5. Begum MR, Fedrous J, Begum A, Quadir E. Comparison of efficacy of aromatase inhibitor and clomiphene citrate in induction of ovulation in polycystic ovarian syndrome. FertilSteril. 2009;92(3):853-57
6. Jirege PR, Patill RS. Comparison of endocrine and ultrasound profiles during ovulation induction with clomiphene citrate and letrozole in ovulatory volunteer women. FertilSteril. 2010;93(1):174-83
7. Johnson N. Metformin is a reasonable first-line treatment option for non-obese women with infertility related to anovulatory polycystic ovary syndrome-A meta-analysis of randomised trials. Aust N Z J ObstetGynaecol. 2011;51:125-9
8. Nestler JE. Metformin for the treatment of the polycystic ovary syndrome. N Engl J Med. 2008;358:47-54
9. Badawy A, Elnashar A. Treatment options for polycystic ovary syndrome. Int J Womens Health. 2011; 3: 25-35
10. Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. Obstet Gynecol. 2010;115(5):1063-70
11. Otta CF, Wior M, Iraci GS, Kaplan R, Torres D, Gaido MI, et al. Clinical, metabolic, and endocrine parameters in response to metformin and lifestyle intervention in women with polycystic ovary syndrome: a randomized, double-blind, and placebo control trial. GynecolEndocrinol. 2010;26(3):173-8
12. Sangeeta S. Metformin and pioglitazone in polycystic ovarian syndrome: a comparative study. J ObstetGynaecol India. 2012;62(5):551-56
13. Tang T, Lord JM, Norman RJ. Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane Database Syst Rev. 2012;5:CD003053
14. Ota H, Goto T, Yoshioka T, Ohyama N. Successful pregnancies treated with pioglitazone in infertile patients with polycystic ovary syndrome. FertilSteril. 2008 Sep;90(3):709-13
15. Li XJ, Yu YX, Liu CQ, Zhang W, Zhang HJ, Yan B, Wang LY, et al. Metformin vs thiazolidinediones for treatment of clinical, hormonal and metabolic characteristics of polycystic ovary syndrome: a meta-analysis.ClinEndocrinol (Oxf). 2011 Mar;74(3):332-9
16. Lord JM, Flight IH, Norman RJ. Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ. 2003;327:951-53
17. Aroda VR, Ciaraldi TP, Burke P. Metabolic and hormonal changes Induced by pioglitazone in polycystic ovary syndrome: a randomized, placebo-controlled clinical trial. J ClinEndocrinolMetabol. 2009;94:469-76
18. Brettenthaler N, De Geyter C, Huber PR, Keller U. Effect of the insulin sensitizer pioglitazone on insulin resistance, hyperandrogenism, and ovulatory dysfunction in women with polycystic ovary syndrome. J ClinEndocrinolMetab 2004;89(8):3835-40
19. Glueck CJ, Moreira A, Goldenberg N, et al. Pioglitazone and metformin in obese women with polycystic ovary syndrome not optimally responsive to metformin. Hum Reprod2003;18:1618-25