Synergistic antioxidative effect of astaxanthin and tocotrienol by co-encapsulated in liposomes

Journal of Clinical Biochemistry and Nutrition

Volumn 59, Issue 2, 2016, Pages 100-106

  Kamezaki, Chihiro ^a   Nakashima, Ami ^a   Yamada, Asako ^a   Uenishi, Sachiko ^a   Ishibashi, Hiroshi ^a   Shibuya, Natsumi ^c   Hama, Susumu ^a   Hosoi, Shinzo ^a   Yamashita, Eiji ^b   Kogure, Kentaro ^a,c  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b AstaReal Co Ltd   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Astaxanthin; Intermolecular interaction; Synergistic activity; Tocotrienol; Vitamin E

Indexed keywords

ALKENE DERIVATIVE; ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; ASTAXANTHIN; GAMMA TOCOTRIENOL; HYDROGEN; HYDROXYL RADICAL; LIPOSOME; POLYENE; SINGLET OXYGEN; TRIENE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; DRUG FORMULATION; DRUG POTENCY; DRUG POTENTIATION; DRUG STABILITY; ENCAPSULATION; HYDROGEN BOND; HYDROXYL RADICAL SCAVENGING ASSAY; IN VITRO STUDY; LIPOSOMAL DELIVERY;

EID: 84988934724     PISSN: 09120009     EISSN: None     Source Type: Journal    
DOI: 10.3164/jcbn.15-153     Document Type: Article

References (16)

1. Boussiba S, Fan L, Vonshak A. Enhancement and determination of astaxanthin accumulation in green alga Haematococcus pluvialis. Method Enzymol 1992; 213: 386-391.
2. Maoka T. Carotenoids in marine animals. Mar Drugs 2011; 9: 278-293.
3. Fukuzawa K. Singlet oxygen scavenging in phospholipid membranes. Methods Enzymol 2000; 319: 101-110.
4. Terao J. Antioxidant activity of beta-carotene-related carotenoids in solution. Lipids 1989; 24: 659-661.
5. Lim BP, Nagao A, Terao J, Tanaka K, Suzuki T, Takama K. Antioxidant activity of xanthophylls on peroxyl radical-mediated phospholipid peroxidation. Biochim Biophys Acta 1992; 1126: 178-184.
6. Palozza P, Krinsky NI. Astaxanthin and canthaxanthin are potent antioxidants in a membrane model. Arch Biochem Biophys 1992; 297: 291-295.
7. Goto S, Kogure K, Abe K, et al. Efficient radical trapping at the surface and inside the phospholipid membrane is responsible for highly potent antiperoxidative activity of the carotenoid astaxanthin. Biochim Biophys Acta 2001; 1512: 251-258.
8. Stahl W, Sies H. Bioactivity and protective effects of natural carotenoids. Biochim Biophys Acta 2005; 1740: 101-107.
9. Hama S, Uenishi S, Yamada A, et al. Scavenging of hydroxyl radicals in aqueous solution by astaxanthin encapsulated in liposomes. Biol Pharm Bull 2012; 35: 2238-2242.
10. Hama S, Takahashi K, Inai Y, et al. Protective effects of topical application of a poorly soluble antioxidant astaxanthin liposomal formulation on ultraviolet- induced skin damage. J Pharm Sci 2012; 101: 2909-2916.
11. Niki E. Role of vitamin E as a lipid-soluble peroxyl radical scavenger: In vitro and in vivo evidence. Free Radic Biol Med 2014; 66: 3-12.
12. Fukuzawa K. Dynamics of lipid peroxidation and antioxidion of alphatocopherol in membranes. J Nutr Sci Vitaminol (Tokyo) 2008; 54: 273-285.
13. Nakano M, Onodera A, Saito E, et al. Effect of astaxanthin in combination with alpha-tocopherol or ascorbic acid against oxidative damage in diabetic ODS rats. J Nutr Sci Vitaminol (Tokyo) 2008; 54: 329-334.
14. Kajimoto K, Yamamoto M, Watanabe M, et al. Noninvasive and persistent transfollicular drug delivery system using a combination of liposomes and iontophoresis. Int J Pharm 2011; 403: 57-65.
15. Hosaka S, Obuki M, Nakajima J, Suzuki M. Comparative study of antioxidants as quenchers or scavengers of reactive oxygen species based on quenching of MCLA-dependent chemiluminescence. Luminescence 2005; 20: 419-427.
16. Jomova K, Valko M. Advances in metal-induced oxidative stress and human disease. Toxicology 2011; 283: 65-87.