Fatigue in multiple sclerosis: Misconceptions and future research directions

Frontiers in Neurology

Volumn 7, Issue AUG, 2016, Pages

  Rudroff, Thorsten ^a   Kindred, John H ^a   Ketelhut, Nathaniel B ^a  

^a Veterinary Dentistry and Oral Surgery   (United States)

Author keywords

Multiple sclerosis; Neuroimaging; Perceptions; Performance fatigability; Questionnaires

Indexed keywords

AROUSAL; ARTICLE; COGNITIVE DEFECT; DEPRESSION; FATIGUE; FATIGUE IMPACT SCALE; FATIGUE SEVERITY SCALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; MENTAL PERFORMANCE; MOTIVATION; MULTIPLE SCLEROSIS; NERVE EXCITABILITY; NERVOUS SYSTEM INFLAMMATION; NEUROIMAGING; NEUROTRANSMISSION; PHYSICAL PERFORMANCE; QUALITY OF LIFE; TASK PERFORMANCE;

EID: 84988835580     PISSN: None     EISSN: 16642295     Source Type: Journal    
DOI: 10.3389/fneur.2016.00122     Document Type: Article

References (56)

1. Brañas P, Jordan R, Fry-Smith A, Burls A, Hyde C. Treatments for fatigue in multiple sclerosis: a rapid and systematic review. Health Technol Assess (2000) 4:1-61. doi: 10.3310/hta4270
2. DeLuca J, Genova HM, Capili EJ, Wylie GR. Functional neuroimaging of fatigue. Phys Med Rehabil Clin N Am (2009) 20:325-37. doi:10.1016/j.pmr.2008.12.007
3. Kluger BM, Krupp LB, Enoka RM. Fatigue and fatigability in neurologic illness: proposal for a unified taxonomy. Neurology (2013) 80:409-16. doi:10.1212/WNL.0b013e31827f07be
4. Heine M, van de Port I, Rietberg MB, van Wegen EE, Kwakkel G. Exercise therapy for fatigue in multiple sclerosis. Cochrane Database Syst Rev (2015) 9:1. doi:10.1002/14651858.CD009956.pub2
5. Berger JR. Functional improvements and symptom management in multiple sclerosis: clinical efficacy and current therapies. Am J Manag Care (2011) 17:S146-53.
6. Bigland-Ritchie B. EMG/force relations and fatigue of human voluntary contractions. Exerc Sport Sci Rev (1981) 9:75-117. doi:10.1249/00003677-198101000-00002
7. Bigland-Ritchie B, Rice CL, Garland SJ, Walsh MML. Task-dependent factors in fatigue of human voluntary contractions. In: Gandevia SC, Enoka RM, McComas AJ, Stuart DG, Thomas CK, editors. Fatigue: Neural and Muscular Mechanisms. New York: Plenum (1995). p. 361-80.
8. Enoka RM, Stuart DG. Neurobiology of muscle fatigue. J Appl Physiol (1985) (1992) 72:1631-48.
9. Enoka RM, Baudry S, Rudroff T, Farina D, Klass M, Duchateau J. Unraveling the neurophysiology of muscle fatigue. J Electromyogr Kinesiol (2011) 21:208-19. doi:10.1016/j.jelekin.2010.10.006
10. Strober LB, Arnett PA. An examination of four models predicting fatigue in multiple sclerosis. Arch Clin Neuropsychol (2005) 20:631-46. doi:10.1016/j.acn.2005.04.002
11. Noronha MJ, Vas CJ, Aziz H. Autonomic dysfunction (sweating responses) in multiple sclerosis. J Neurol Neurosurg Psychiatry (1968) 31:19-22. doi:10.1136/jnnp.31.1.19
12. Marin H, Menza MA. Specific treatment of residual fatigue in depressed patients. Psychiatry (Edgmont) (2004) 1:12-8.
13. Dzurec LC. Experiences of fatigue and depression before and after low-dose 1-thyroxine supplementation in essentially euthyroid individuals. Res Nurs Health (1997) 20(5):389-98. doi:10.1002/(SICI)1098-240X(199710)20:5<389::AID-NUR3>3.0.CO;2-K
14. Motl RW, Sandroff BM. Benefits of exercise training in multiple sclerosis. Curr Neurol Neurosci Rep (2015) 15:62. doi:10.1007/s11910-015-0585-6
15. Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol (1989) 46:1121-3. doi:10.1001/archneur.1989.00520460115022
16. Fisk JD, Pontefract A, Ritvo PG, Archibald CJ, Murray TJ. The impact of fatigue on patients with multiple sclerosis. Can J Neurol Sci (1994) 21:9-14. doi:10.1017/S0317167100048691
17. Gobbi C, Rocca MA, Riccitelli G, Pagani E, Messini R, Preziosa P, et al. Influence of the topography of brain damage on depression and fatigue in patients with multiple sclerosis. Mult Scler (2014) 20:192-201. doi:10.1177/1352458513493684
18. Pellicano C, Gallo A, Li X, Ikonomidou VN, Evangelou IE, Ohayon JM, et al. Relationship of cortical atrophy to fatigue in patients with multiple sclerosis. Arch Neurol (2010) 67:447-53. doi:10.1001/archneurol.2010.48
19. Pardini M, Bonzano L, Bergamino M, Bommarito G, Feraco P, Murugavel A, et al. Cingulum bundle alterations underlie subjective fatigue in multiple sclerosis. Mult Scler (2015) 21:442-7. doi:10.1177/1352458514546791
20. Andreasen AK, Spliid PE, Andersen H, Jakobsen J. Fatigue and processing speed are related in multiple sclerosis. Eur J Neurol (2010) 17:212-8. doi:10.1111/j.1468-1331.2009.02776.x
21. Labuz-Roszak B, Kubicka-Baczyk K, Pierzchala K, Machowska-Majchrzak A, Skrzypek M. Fatigue and its associations with sleep disorders, depressive symptoms and anxiety in patients with multiple sclerosis. Neurol Neurochir Pol (2012) 46:309-17. doi:10.5114/ninp.2012.30261
22. Smith RL, Lucaccini LF, Epstein MH. Effects of monetary rewards and punishment on vigilance performance. J Appl Psychol (1967) 51:411-6. doi:10.1037/h0025045
23. Ansley L, Robson PJ, St Clair Gibson A, Noakes TD. Anticipatory pacing strategies during supramaximal exercise lasting longer than 30 s. Med Sci Sports Exerc (2004) 36:209-14. doi:10.1249/01.MSS.0000113474.31529.C6
24. Marcora S. Counterpoint: afferent feedback from fatigued locomotor muscles is not an important determinant of endurance exercise performance. J Appl Physiol (1985) (2010) 108:454-6. doi:10.1152/japplphysiol.01393.2009
25. Feinstein A, Magalhaes S, Richard JF, Audet B, Moore C. The link between multiple sclerosis and depression. Nat Rev Neurol (2014) 10:507-17. doi:10.1038/nrneurol.2014.139
26. Bakshi R, Shaikh ZA, Miletich RS, Czarnecki D, Dmochowski J, Henschel K, et al. Fatigue in multiple sclerosis and its relationship to depression and neurologic disability. Mult Scler (2000) 6:181-5. doi:10.1191/135245800701566052
27. Patejdl R, Penner IK, Noack TK, Zettl UK. Multiple sclerosis and fatigue: a review on the contribution of inflammation and immune-mediated neurodegeneration. Autoimmun Rev (2016) 15(3):210-20. doi:10.1016/j.autrev.2015.11.005
28. Flachenecker P, Bihler I, Weber F, Gottschalk M, Toyka KV, Rieckmann P. Cytokine mRNA expression in patients with multiple sclerosis and fatigue. Mult Scler (2004) 10:165-9. doi:10.1191/1352458504ms991oa
29. Heesen C, Nawrath L, Reich C, Bauer N, Schulz K, Gold SM. Fatigue in multiple sclerosis: an example of cytokine mediated sickness behavior? J Neurol Neurosurg Psychiatry (2006) 77:34-9. doi:10.1136/jnnp.2005.065805
30. Malekzadeh A, Van de Geer-Peeters W, De Groot V, Teunissen CE, Beckerman H, TREFAMS-ACE Study Group. Fatigue in patients with multiple sclerosis: is it related to pro-and anti-inflammatory cytokines? Dis Markers (2015) 2015(2015):758314. doi:10.1155/2015/758314
31. Giovannoni G, Thompson AJ, Miller DH, Thompson EJ. Fatigue is not associated with raised inflammatory markers in multiple sclerosis. Neurology (2001) 57:676-81. doi:10.1212/WNL.57.4.676
32. Heesen C, Koehler G, Gross R, Tessmer W, Schulz K, Gold SM. Altered cytokine mRNA expression in multiple sclerosis patients with fatigue. Mult Scler (2005) 11:51-7. doi:10.1191/1352458505ms1129oa
33. Roelcke U, Kappos L, Lechner-Scott J, Brunnschweiler H, Huber S, Ammann W, et al. Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue: a 18F-fluorodeoxyglucose positron emission tomography study. Neurology (1997) 48:1566-71. doi:10.1212/WNL.48.6.1566
34. Genova HM, Rajagopalan V, DeLuca J, Das A, Binder A, Arjunan A, et al. Examination of cognitive fatigue in multiple sclerosis, using functional magnetic resonance imaging and diffusion tensor imaging. PLoS One (2013) 8:e78811. doi:10.1371/journal.pone.0078811
35. Delis DC, Kaplan E, Kramer JH. Delis-Kaplan Executive Function System (D-KEFS). San Antonio, TX: The Psychological Corporation (2001).
36. Rocca MA, Meani A, Riccitelli GC, Colombo B, Rodegher M, Falini A, et al. Abnormal adaptation over time of motor network recruitment in multiple sclerosis patients with fatigue. Mult Scler (2015). doi:10.1177/1352458515614407
37. Dobryakova E, Genova HM, DeLuca J, Wylie GR. The dopamine imbalance hypothesis of fatigue in multiple sclerosis and other neurological disorders. Front Neurol (2015) 6:52. doi:10.3389/fneur.2015.00052
38. Seamans JK, Yang CR. The principal features and mechanisms of dopamine modulation in the prefrontal cortex. Prog Neurobiol (2004) 74:1-58. doi:10.1016/j.pneurobio.2004.10.002
39. Haber SN, Fudge JL, McFarland NR. Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum. J Neurosci (2000) 20:2369-82.
40. Rönnbäck L, Hansson E. On the potential role of glutamate transport in mental fatigue. J Neuroinflammation (2004) 1:22. doi:10.1186/1742-2094-1-22
41. Tedeschi G, Dinacci D, Lavorgna L, Prinster A, Savettieri G, Quattrone A, et al. Correlation between fatigue and brain atrophy and lesion load in multiple sclerosis patients independent of disability. J Neurol Sci (2007) 263:15-9. doi:10.1016/j.jns.2007.07.004
42. Sepulcre J, Masdeu JC, Goñi J, Arrondo G, Vélez de Mendizábal N, Bejarano B, et al. Fatigue in multiple sclerosis is associated with the disruption of frontal and parietal pathways. Mult Scler (2009) 15:337-44. doi:10.1177/1352458508098373
43. Bol Y, Duits AA, Hupperts RMM, Vlaeyen JWS, Verhey FRJ. The psychology of fatigue in patients with multiple sclerosis: a review. J Psychosom Res (2009) 66:3-11. doi:10.1016/j.jpsychores.2008.05.003
44. Meussen R, Watson P, Hasegawa H, Roelands B, Piacentini MF. Central fatigue: the serotonin hypothesis and beyond. Sports Med (2006) 36:881-909. doi:10.2165/00007256-200636100-00006
45. Foley TE, Fleshner M. Neuroplasticity of dopamine circuits after exercise: implications for central fatigue. Neuromolecular Med (2008) 10:67-80. doi:10.1007/s12017-008-8032-3
46. Engström M, Flensner G, Landtblom AM, Ek AC, Karlsson T. Thalamo-striato-cortical determinants to fatigue in multiple sclerosis. Brain Behav (2013) 3:715-28. doi:10.1002/brb3.181
47. Finke C, Schlichting J, Papazoglou S, Scheel M, Freing A, Soemmer C, et al. Altered basal ganglia functional connectivity in multiple sclerosis patients with fatigue. Mult Scler (2015) 21:925-34. doi:10.1177/1352458514555784
48. Kent-Braun JA, Sharma KR, Miller RG, Weiner MW. Postexercise phosphocreatine resynthesis is slowed in multiple sclerosis. Muscle Nerve (1994) 17:835-41. doi:10.1002/mus.880170802
49. Rice CL, Vollmer TL, Bigland-Ritchie B. Neuromuscular responses of patients with multiple sclerosis. Muscle Nerve (1992) 15:1123-32. doi:10.1002/mus.880151011
50. Sharma KR, Kent-Braun J, Mynhier MA, Weiner MW, Miller RG. Evidence of an abnormal intramuscular component of fatigue in multiple sclerosis. Muscle Nerve (1995) 18:1403-11. doi:10.1002/mus.880181210
51. Sheean GL, Murray NM, Rothwell JC, Miller DH, Thompson AJ. An electrophysiological study of the mechanism of fatigue in multiple sclerosis. Brain (1997) 120:299-315. doi:10.1093/brain/120.2.299
52. Kent-Braun JA, Ng AV, Castro M, Weiner MW, Gelinas D, Dudley GA, et al. Strength, skeletal muscle composition, and enzyme activity in multiple sclerosis. J Appl Physiol (1985) (1997) 83:1998-2004.
53. Kent-Braun JA, Sharma KR, Weiner MW, Miller RG. Effects of exercise on muscle activation and metabolism in multiple sclerosis. Muscle Nerve (1994) 17:1162-9. doi:10.1002/mus.880171006
54. Ng AV, Dao HT, Miller RG, Gelinas DF, Kent-Braun JA. Blunted pressor and intramuscular metabolic responses to voluntary isometric exercise in multiple sclerosis. J Appl Physiol (1985) (2000) 88:871-80.
55. Noakes TD, Clair Gibson A, Lambert EV. From catastrophe to complexity: a novel model of integrative central neural regulation of effort and fatigue during exercise in humans: summary and conclusions. Br J Sports Med (2005) 39:120-4. doi:10.1136/bjsm.2003.010330
56. Roa SM. A Manual for the Brief Repeatable Battery of Neuropsychological Tests in Multiple Sclerosis. New York: National Multiple Sclerosis Society (1990).