Low-grade Appendiceal Mucinous Neoplasm of Uncertain Malignant Potential (LAMN-UMP): Prognostic Factors and Implications for Treatment and Follow-up

Annals of Surgical Oncology

Volumn 24, Issue 1, 2017, Pages 187-193

  Fournier, Keith ^a   Rafeeq, Safia ^a   Taggart, Melissa ^a   Kanaby, Paul ^a   Ning, Jing ^a   Chen, Hsiang Chun ^a   Overman, Michael ^a   Raghav, Kanwal ^a   Eng, Cathy ^a   Mansfield, Paul ^a   Royal, Richard ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CA 125 ANTIGEN; CA 19-9 ANTIGEN; CARCINOEMBRYONIC ANTIGEN; MUCIN; TUMOR MARKER;

ADULT; AGED; APPENDECTOMY; APPENDIX PERFORATION; APPENDIX TUMOR; ARTICLE; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER SURGERY; CANCER SURVIVAL; COLON RESECTION; COMPUTER ASSISTED TOMOGRAPHY; CYTOREDUCTIVE SURGERY; DISEASE FREE SURVIVAL; FEMALE; FOLLOW UP; HUMAN; HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; LOW GRADE APPENDICEAL MUCINOUS NEOPLASM OF UNCERTAIN MALIGNANT POTENTIAL; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PERITONEUM; RECURRENCE RISK; RECURRENT DISEASE; SURGICAL MARGIN; SURVIVAL RATE; TREATMENT INDICATION; TUMOR DIFFERENTIATION; CANCER GRADING; COLLOID CARCINOMA; MIDDLE AGED; PATHOLOGY; PROGNOSIS; RETROSPECTIVE STUDY; SURVIVAL ANALYSIS; TREATMENT OUTCOME; VERY ELDERLY;

ADENOCARCINOMA, MUCINOUS; ADULT; AGED; AGED, 80 AND OVER; APPENDECTOMY; APPENDICEAL NEOPLASMS; BIOMARKERS, TUMOR; COLECTOMY; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASM GRADING; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 84988709989     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-016-5588-2     Document Type: Article

References (28)

1. Connor SJ, Hanna GB, Frizelle FA. Appendiceal tumors: retrospective clinicopathologic analysis of appendiceal tumors from 7970 appendectomies. Dis Colon Rectum. 1998;41:75–80.
2. McCusker ME, Cote TR, Clegg LX, et al. Primary malignant neoplasms of the appendix: a population-based study from the surveillance, epidemiology and end-results program, 1973–1998. Cancer. 2002;94:3307–12.
3. Misdraji J. Appendiceal mucinous neoplasms: controversial issues. Arch Pathol Lab Med. 2010;134:864–70.
4. Panarelli NC, Yantiss RK. Mucinous neoplasms of the appendix and peritoneum. Arch Pathol Lab Med. 2011;135:1261–8.
5. Gibbs NM. Mucinous cystadenoma and cystadenocarcinoma of the vermiform appendix with particular reference to mucocele and pseudomyxoma peritonei. J Clin Pathol. 1973;26:413–21.
6. Higa E, Rosai J, Pizzimbono CA, et al. Mucosal hyperplasia, mucinous cystadenoma, and mucinous cystadenocarcinoma of the appendix. A re-evaluation of appendiceal “mucocele.” Cancer. 1973;32:1525–41.
7. Prayson RA, Hart WR, Petras RE. Pseudomyxoma peritonei. A clinicopathologic study of 19 cases with emphasis on site of origin and nature of associated ovarian tumors. Am J Surg Pathol. 1994;18:591–603.
8. Cuatrecasas M, Matias-Guiu X, Prat J. Synchronous mucinous tumors of the appendix and the ovary associated with pseudomyxoma peritonei. A clinicopathologic study of six cases with comparative analysis of c-Ki-ras mutations. Am J Surg Pathol. 1996;20:739–46.
9. Chuaqui RF, Zhuang Z, Emmert-Buck MR, et al. Genetic analysis of synchronous mucinous tumors of the ovary and appendix. Hum Pathol. 1996;27:165–71.
10. Ronnett BM, Shmookler BM, Diener-West M, et al. Immunohistochemical evidence supporting the appendiceal origin of pseudomyxoma peritonei in women. Int J Gynecol Pathol. 1997;16:1–9.
11. Teixeira MR, Qvist H, Giercksky KE, et al. Cytogenetic analysis of several pseudomyxoma peritonei lesions originating from a mucinous cystadenoma of the appendix. Cancer Genet Cytogenet. 1997;93:157–9.
12. Szych C, Staebler A, Connolly DC, et al. Molecular genetic evidence supporting the clonality and appendiceal origin of pseudomyxoma peritonei in women. Am J Pathol. 1999;154:1849–55.
13. Young RH. Pseudomyxoma peritonei and selected other aspects of the spread of appendiceal neoplasms. Semin Diagn Pathol. 2004;21:134–50.
14. Seidman JD, Elsayed AM, Sobin LH, et al. Association of mucinous tumors of the ovary and appendix. A clinicopathologic study of 25 cases. Am J Surg Pathol. 1993;17:22–34.
15. Carr NJ, Sobin LH. Epithelial noncarcinoid tumors and tumor-like lesions of the appendix. Cancer. 1995;76:2383–4.
16. Carr NJ, Sobin LH. Unusual tumors of the appendix and pseudomyxoma peritonei. Semin Diagn Pathol. 1996;13:314–25.
17. Pai RK, Longacre TA. Appendiceal mucinous tumors and pseudomyxoma peritonei: histologic features, diagnostic problems, and proposed classification. Adv Anat Pathol. 2005;12:291–311.
18. Carr NJ, Sobin LH. Adenocarcinoma of the appendix. In: Bosman F, Carneiro F, Hruban R, Theise N, editors. WHO classification of tumours of the digestive system. Lyon: International Agency for Research on Cancer; 2010. p. 122–5.
19. Misdraji J, Yantiss RK, Graeme-Cook FM, et al. Appendiceal mucinous neoplasms: a clinicopathologic analysis of 107 cases. Am J Surg Pathol. 2003;27:1089–103.
20. Yantiss RK, Shia J, Klimstra DS, et al. Prognostic significance of localized extra-appendiceal mucin deposition in appendiceal mucinous neoplasms. Am J Surg Pathol. 2009;33:248–55.
21. Pai RK, Beck AH, Norton JA, et al. Appendiceal mucinous neoplasms: clinicopathologic study of 116 cases with analysis of factors predicting recurrence. Am J Surg Pathol. 2009;33:1425–39.
22. SAS Institute Inc. SAS/STAT, user’s guide, version 9. Cary, NC: SAS Institute; 2003.
23. Venables W, Ripley B. Modern applied statistics with S-PLUS. New York: Springer; 1999.
24. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457–81.
25. Cox DR. Regression models and life tables. J R Stat Soc B. 1972;34:187–220.
26. Chua TC, Moran BJ, Sugarbaker PH, et al. Early-and long-term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. J Clin Oncol. 2012;30:2449–56.
27. Youssef H, Newman C, Chandrakumaran K, et al. Operative findings, early complications, and long-term survival in 456 patients with pseudomyxoma peritonei syndrome of appendiceal origin. Dis Colon Rectum. 2011;54:293–9.
28. Dineen SP, Royal RE, Hughes MS, et al. A simplified preoperative assessment predicts complete cytoreduction and outcomes in patients with low-grade mucinous adenocarcinoma of the appendix. Ann Surg Oncol. 2015;22:3640–6.