Intravenous angiotensin II for the treatment of high-output shock (ATHOS trial): A pilot study

Critical Care

Volumn 18, Issue 5, 2014, Pages

  Chawla, Lakhmir S ^a,c   Busse, Laurence ^b   Brasha Mitchell, Ermira ^c   Davison, Danielle ^c   Honiq, Jacqueline ^c   Alotaibi, Ziyad ^d   Seneff, Michael G ^c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b Section of Critical Care Medicine Department of Medicine Inova Fairfax Medical Center   (United States)

^c GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^d Critical Care and Emergency Medicine ^*  (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; NORADRENALIN; PLACEBO; CATECHOLAMINE; VASOCONSTRICTOR AGENT;

ACIDOSIS; ACUTE KIDNEY FAILURE; ADULT; AGED; ALKALOSIS; ARTICLE; ATRIAL FIBRILLATION; CLINICAL ARTICLE; COHORT ANALYSIS; CONTINUOUS INFUSION; CONTROLLED STUDY; DOSE CALCULATION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG EFFECT; DRUG EFFICACY; DRUG TOLERABILITY; DRUG WITHDRAWAL; FEMALE; HEALTH CARE QUALITY; HEART DISEASE; HEMATOLOGIC DISEASE; HIGH OUTPUT SHOCK; HUMAN; HYPERTENSION; HYPOTENSION; KIDNEY DISEASE; LYMPHATIC SYSTEM DISEASE; MALE; MEAN ARTERIAL PRESSURE; METABOLIC DISORDER; MORTALITY; MULTIPLE ORGAN FAILURE; PILOT STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY FAILURE; RESPIRATORY TRACT DISEASE; SEPTIC SHOCK; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; SHOCK; SIDE EFFECT; URINE VOLUME; WHEEZING; BLOOD PRESSURE; HEART OUTPUT; INTRAVENOUS DRUG ADMINISTRATION; MIDDLE AGED; SHOCK, SEPTIC; TREATMENT OUTCOME;

ADMINISTRATION, INTRAVENOUS; AGED; ANGIOTENSIN II; BLOOD PRESSURE; CARDIAC OUTPUT; CATECHOLAMINES; FEMALE; HUMANS; MALE; MIDDLE AGED; NOREPINEPHRINE; PILOT PROJECTS; SHOCK, SEPTIC; TREATMENT OUTCOME; VASOCONSTRICTOR AGENTS;

EID: 84988699916     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-014-0534-9     Document Type: Article

References (19)

1. Vincent JL, De Backer D: Circulatory shock. N Engl J Med 2013, 369:1726-1734.
2. Myburgh JA, Higgins A, Jovanovska A, Lipman J, Ramakrishnan N, Santamaria J, CAT Study investigators: A comparison of epinephrine and norepinephrine in critically ill patients. Intensive Care Med 2008, 34:2226-2234.
3. Rona G: Catecholamine cardiotoxicity. J Mol Cell Cardiol 1985, 17:291-306.
4. Morelli A, Ertmer C, Westphal M, Rehberg S, Kampmeier T, Ligges S, Orecchioni A, D'Egidio A, D'Ippoliti F, Raffone C, Venditti M, Guarracino F, Girardis M, Tritapepe L, Pietropaoli P, Mebazaa A, Singer M: Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial. JAMA 2013, 310:1683-1691.
5. Russell JA, Walley KR, Singer J, Gordon AC, Hebert PC, Cooper DJ, Holmes CL, Mehta S, Granton JT, Storms MM, Cook DJ, Presneill JJ, Ayers D, VASST Investigators: Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med 2008, 358:877-887.
6. Basso N, Terragno NA: History about the discovery of the renin-angiotensin system. Hypertension 2001, 38:1246-1249.
7. Struthers AD, MacDonald TM: Review of aldosterone-and angiotensin II-induced target organ damage and prevention. Cardiovasc Res 2004, 61:663-670.
8. Jackson T, Corke C, Agar J: Enalapril overdose treated with angiotensin infusion. Lancet 1993, 341:703.
9. Trilli LE, Johnson KA: Lisinopril overdose and management with intravenous angiotensin II. Ann Pharmacother 1994, 28:1165-1168.
10. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H, Reinhart CK, Suter PM, Thijs LG: The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996, 22:707-710.
11. Newby DE, Lee MR, Gray AJ, Boon NA: Enalapril overdose and the corrective effect of intravenous angiotensin II. Br J Clin Pharmacol 1995, 40:103-104.
12. Wray GM, Coakley JH: Severe septic shock unresponsive to noradrenaline. Lancet 1995, 346:1604.
13. Whiteley SM, Dade JP: Treatment of hypotension in septic shock. Lancet 1996, 347:622.
14. Ryding J, Heslet L, Hartvig T, Jonsson V: Reversal of 'refractory septic shock' by infusion of amrinone and angiotensin II in an anthracycline-treated patient. Chest 1995, 107:201-203.
15. Thomas VL, Nielsen MS: Administration of angiotensin II in refractory septic shock. Crit Care Med 1991, 19:1084-1086.
16. Yunge M, Petros A: Angiotensin for septic shock unresponsive to noradrenaline. Arch Dis Child 2000, 82:388-389.
17. Correa TD, Jeger V, Pereira AJ, Takala J, Djafarzadeh S, Jakob SM: Angiotensin II in Septic Shock: Effects on Tissue Perfusion, Organ Function, and Mitochondrial Respiration in a Porcine Model of Fecal Peritonitis. Crit Care Med 2014, 42:e550-e559.
18. Wan L, Langenberg C, Bellomo R, May CN: Angiotensin II in experimental hyperdynamic sepsis. Crit Care 2009, 13:R190.
19. Goldsmith SR, Hasking GJ: Effect of a pressor infusion of angiotensin II on sympathetic activity and heart rate in normal humans. Circ Res 1991, 68:263-268.