Evaluation of prehospital blood products to attenuate acute coagulopathy of trauma in a model of severe injury and shock in anesthetized pigs

Shock

Volumn 44, Issue , 2015, Pages 138-148

  Watts, Sarah ^a   Nordmann, Giles ^a   Brohi, Karim ^b   Midwinter, Mark ^c   Woolley, Tom ^a   Gwyther, Robert ^a   Wilson, Callie ^a   Poon, Henrietta ^a   Kirkman, Emrys ^a  

^a Queen Mary University of London ^*  (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Blood; Coagulopathy; Plasma; Shock; Trauma

Indexed keywords

FIBRINOGEN; FRESH FROZEN PLASMA; LACTIC ACID; SODIUM CHLORIDE;

ALKALOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PH; ARTICLE; BLOOD VOLUME; BODY TEMPERATURE; BODY WEIGHT; COMPARATIVE STUDY; CONTROLLED STUDY; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE TRANSFUSION; EXPERIMENTAL PIG; FEMALE; FIBRINOGEN BLOOD LEVEL; HEMATOCRIT; HEMODILUTION; HEMORRHAGIC SHOCK; HYPOTENSION; INJURY SEVERITY; LACTATE BLOOD LEVEL; NONHUMAN; OXYGEN TRANSPORT; PARTIAL THROMBOPLASTIN TIME; RESUSCITATION; SHOCK; SOFT TISSUE INJURY; SYSTOLIC BLOOD PRESSURE; THROMBOCYTE COUNT; THROMBOELASTOGRAPHY; YORKSHIRE PIG; ANESTHESIA; ANIMAL; BLOOD; BLOOD BANK; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; CHEMISTRY; DISEASE MODEL; HEMORRHAGE; PIG; PLASMA; PROCEDURES; PROTHROMBIN TIME; TIME FACTOR; WOUNDS AND INJURIES;

ANESTHESIA; ANIMALS; BLOOD BANKS; BLOOD COAGULATION; BLOOD COAGULATION DISORDERS; DISEASE MODELS, ANIMAL; ERYTHROCYTE TRANSFUSION; FEMALE; FIBRINOGEN; HEMORRHAGE; PARTIAL THROMBOPLASTIN TIME; PLASMA; PROTHROMBIN TIME; RESUSCITATION; SHOCK; SWINE; THROMBELASTOGRAPHY; TIME FACTORS; WOUNDS AND INJURIES;

EID: 84988689048     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000409     Document Type: Article

References (45)

1. Findlay G, Martin IC, Carter S, Smith N, Weyman D, Mason M, (eds.): Trauma: Who cares? In: A Report of the National Confidential Enquiry Into Patient Outcome and Death. 1-151, 2007.
2. Chiara O, Cimbanassi S: Organized trauma care: does volume matter and do trauma centers save lives? Curr Opin Crit Care 9(6):510-514, 2003.
3. Sauaia A, Moore FA, Moore EE, Moser KS, Brennan R, Read RA, et al.: Epidemiology of trauma deaths: A reassessment. J Trauma 38(2):185-193, 1995.
4. Champion HR, Bellamy RF, Roberts CP, Leppaniemi A: A profile of combat injury. J Trauma 54(Suppl5): S13-S19, 2003.
5. Holcomb JB, McMullin NR, Pearse L, Caruso J, Wade CE, Oetjen-Gerdes L, et al.: Causes of death in U.S. Special Operations Forces in the global war on terrorism: 2001-2004. Ann Surg 245(6):986-991, 2007.
6. Asehnoune K, Faraoni D, Brohi K: What's new in management of traumatic coagulopathy? Intensive Care Med [Internet] 40(11):1727-1730, 2014.
7. Maegele M, Schöchl H, Cohen MJ: An update on the coagulopathy of trauma. Shock [Internet] 41(Suppl1):21-25, 2014.
8. Cap A, Hunt BJ: The pathogenesis of traumatic coagulopathy. Anaesthesia [Internet] 70(Suppl1):96-101, 2014, e32Ye34.
9. Brohi K, Singh J, Heron M, Coats T: Acute traumatic coagulopathy. J Trauma [Internet] 54(6):1127-1130, 2003.
10. Maegele M, Lefering R, Yucel N, Tjardes T, Rixen D, Paffrath T, et al.: Early coagulopathy in multiple injury: An analysis from the German Trauma Registry on 8724 patients. Injury [Internet] 38(3):298-304, 2007.
11. MacLeod JBA, Lynn M, McKenney MG, Cohn SM, Murtha M: Early coagulopathy predicts mortality in trauma. J Trauma 55(1):39-44, 2003.
12. Niles SE, McLaughlin DF, Perkins JG, Wade CE, Li Y, Spinella PC, et al.: Increased mortality associated with the early coagulopathy of trauma in combat casualties. J Trauma 64(6):1459-1463, 2008, discussion 1465.
13. Woolley T, Midwinter M, Spencer P, Watts S, Doran C, Kirkman E: Utility of interim ROTEM(A) values of clot strength, A5 and A10, in predicting final assessment of coagulation status in severely injured battle patients. Injury 44(5):593-599, 2013.
14. Hayakawa M, Gando S, Ieko M, Honma Y, Homma T, Yanagida Y, et al.: Massive amounts of tissue factor induce fibrinogenolysis without tissue hypoperfusion in rats. Shock 39(6):514-519, 2013.
15. Pidcoke HF, Aden JK, Mora AG, Borgman MA, Spinella PC, Dubick MA, et al.: Ten-year analysis of transfusion in Operation Iraqi Freedom and Operation Enduring Freedom: increased plasma and platelet use correlates with improved survival. J Trauma Acute Care Surg 73(6 Suppl5):S445-S452, 2012.
16. Moore EE, Chin TL, Chapman MC, Gonzalez E, Moore HB, Silliman CC, et al.: Plasma first in the field for postinjury hemorrhagic shock. Shock 41(Suppl1): 35-38, 2014.
17. Nordmann G, Woolley T, Doughty H, Dalle Lucca J, Hutchings S, Kirkman E: Deployed research. J R Army Med Corps 160(2):92-98, 2014.
18. NICE: Pre-hospital Initiation of Fluid Replacement Therapy in Trauma. National Institute for Health and Care Excellence. NICE; 1-32, 2004.
19. UK Defence Medical Education Training Agency: Battlefield Advanced Life Support. 2006.
20. UK Blood Transfusion Services: Guidelines for the Blood Transfusion Services in the United Kingdom. 8th ed. Stationery Office, 2005.
21. Garner J, Watts S, Parry C, Bird J, Cooper G, Kirkman E: Prolonged permissive hypotensive resuscitation is associated with poor outcome in primary blast injury with controlled hemorrhage. Ann Surg [Internet] 251(6):1131-1139, 2010.
22. Stern SA, Dronen SC, Birrer P, Wang X: Effect of blood pressure on hemorrhage volume and survival in a near-fatal hemorrhage model incorporating a vascular injury. Ann Emerg Med 22(2):155-163, 1993.
23. Sørensen B, Fenger-Eriksen C, Christiansen K, Larsen OH, Ingerslev J: Evaluation of coagulation kinetics using thromboelastometry-methodologic influence of activator and test medium. Ann Hematol 89(11):1155-1161, 2010.
24. Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF: Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg 245(5):812-818, 2007.
25. Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, et al.: Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma 64(5):1211-1217, 2008, discussion 1217.
26. Sondeen JL, Prince MD, Kheirabadi BS, Wade CE, Polykratis IA, de Guzman R, et al.: Initial resuscitation with plasma and other blood components reduced bleeding compared to Hetastarch in anesthetized swine with uncontrolled splenic hemorrhage. Transfusion 51(4):779-792, 2010.
27. Pati S, Matijevic N, Doursout M-F, Ko T, Cao Y, Deng X, et al.: Protective effects of fresh frozen plasma on vascular endothelial permeability, coagulation, and resuscitation after hemorrhagic shock are time dependent and diminish between days 0 and 5 after thaw. J Trauma [Internet] 69(Suppl1):S55-S63, 2010.
28. Torres LN, Sondeen JL, Ji L, Dubick MA, Filho IT: Evaluation of resuscitation fluids on endothelial glycocalyx, venular blood flow, and coagulation function after hemorrhagic shock in rats. J Trauma Acute Care Surg [Internet] 75(5):759-766, 2013.
29. Torres LN, Sondeen JL, Dubick MA, Filho IT: Systemic and microvascular effects of resuscitation with blood products after severe hemorrhage in rats. J Trauma Acute Care Surg [Internet] 77(5):716-723, 2014.
30. Peng Z, Pati S, Potter D, Brown R, Holcomb JB, Grill R, et al.: Fresh frozen plasma lessens pulmonary endothelial inflammation and hyperpermeability after hemorrhagic shock and is associated with loss of syndecan 1. Shock 40(3): 195-202, 2013.
31. Lee TH, Van PY, Spoerke NJ, Hamilton GJ, Cho SD, Watson K, et al.: The use of lyophilized plasma in a severe multi-injury pig model. Transfusion [Internet] 53(Suppl1):72S-79S, 2013.
32. Glassberg E, Nadler R, Gendler S, Abramovich A, Spinella PC, Gerhardt RT, et al.: Freeze-dried plasma at the point of injury: from concept to doctrine. Shock [Internet] 40(6):444-450, 2013.
33. Sailliol A, Martinaud C, Cap AP, Civadier C, Clavier B, Deshayes A-V, et al.: The evolving role of lyophilized plasma in remote damage control resuscitation in the French Armed Forces Health Service. Transfusion [Internet] 53(Suppl1): 65S-71S, 2013.
34. Martinaud C, Ausset S, Deshayes A-V, Cauet A, Demazeau N, Sailliol A: Use of freeze-dried plasma in French intensive care Bunit in Afghanistan. J Trauma 71(6):1761-1764, 2011, discussion 1764Y1765.
35. Holcomb JB, Donathan DP, Cotton BA, del Junco DJ, Brown G, Wenckstern TV, et al.: Prehospital transfusion of plasma and red blood cells in trauma patients. Prehosp Emerg Care [Internet] 19(1):1-9, 2015.
36. Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, et al.: Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma. JAMA 313(5):471, 2015.
37. Khan S, Brohi K, Chana M, Raza I, Stanworth S, Gaarder C, et al.: Hemostatic resuscitation is neither hemostatic nor resuscitative in trauma hemorrhage. J Trauma Acute Care Surg [Internet] 76(3): 561-567, 2014 discussion 567Y568.
38. Schrager JJ, Branson RD, Johannigman JA: Lessons from the tip of the spear: medical advancements from Iraq and Afghanistan. Respir Care [Internet] 57(8): 1305-1313, 2012.
39. National Association of Emergency Medical Technicians (NAEMT): Prehospital Trauma Life Support. Military Edition. 8th ed. Jones & Bartlett Publishers, 2014.
40. Frith D, Cohen MJ, Brohi K: Animal models of trauma-induced coagulopathy. Thromb Res 129(5):551-556, 2012.
41. Morrison JJ, Oh J, Dubose JJ, O'Reilly DJ, Russell RJ, Blackbourne LH, et al.: En-route care capability from point of injury impacts mortality after severe wartime injury. Ann Surg 257(2):330-334, 2013.
42. Cho SD, Holcomb JB, Tieu BH, Englehart MS, Morris MS, Karahan ZA, et al.: Reproducibility of an animal model simulating complex combat-related injury in a multiple-institution format. Shock 31(1):87-96, 2009.
43. Hodgetts TJ, Mahoney PF, Russell MQ, Byers M: ABC to ABC: Redefining the military trauma paradigm. Emerg Med J 23(10):745-746, 2006.
44. Kirkman E, Watts S, Cooper G: Blast injury research models. Philos Trans R Soc Lond B Biol Sci 366(1562):144-159, 2011.
45. Martini WZ, Cortez DS, Dubick MA, Park MS, Holcomb JB: Thrombelastography is better than PT, aPTT, and activated clotting time in detecting clinically relevant clotting abnormalities after hypothermia, hemorrhagic shock and resuscitation in pigs. J Trauma [Internet] 65(3):535-543, 2008.