Histopathological and ultra structural effects of nanoparticles on rat testis following 90 days (Chronic study) of repeated oral administration

Journal of Nanobiotechnology

Volumn 12, Issue 1, 2014, Pages

  Thakur, Mansee ^a   Gupta, Himanshu ^b   Singh, Dipty ^c   Mohanty, Ipseeta R ^d   Maheswari, Ujjwala ^d   Vanage, Geeta ^c   Joshi, D ^a,b  

^a Mumbai University   (India)

^b Research Laboratories   (India)

^c NATIONAL INSTITUTE FOR RESEARCH IN REPRODUCTIVE HEALTH   (India)

^d Mahatma Gandhi Mission Institute of Health Sciences   (India)

Author keywords

Chronic study; Distribution; Nanoparticles; Oral exposure; Toxicity

Indexed keywords

ANIMALS; CELL CULTURE; CELLS; CYTOLOGY; HIGH RESOLUTION TRANSMISSION ELECTRON MICROSCOPY; HISTOLOGY; NANOPARTICLES; RATS; TOXICITY; TRANSMISSION ELECTRON MICROSCOPY;

CHRONIC STUDY; DISTRIBUTION; EXPERIMENTAL GROUPS; EXPERIMENTAL INVESTIGATIONS; HISTOLOGICAL FEATURES; ORAL ADMINISTRATION; ORAL EXPOSURE; TRANSMISSION ELECTRON;

SILVER;

SILVER NANOPARTICLE; METAL NANOPARTICLE; SILVER;

ACUTE TOXICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL ULTRASTRUCTURE; CELL VACUOLE; CHRONIC TOXICITY; CONTROLLED STUDY; FIBROBLAST; HISTOPATHOLOGY; INTERCELLULAR SPACE; LEYDIG CELL; MALE; MITOCHONDRION; NANOTOXICOLOGY; NONHUMAN; PARTICLE SIZE; RAT; REPRODUCTIVE TOXICITY; SERTOLI CELL; SPERMATOCYTE; SPERMATOGENESIS; SPERMATOGONIUM; STRUCTURE ANALYSIS; TESTIS; TESTIS INJURY; TISSUE STRUCTURE; TRANSMISSION ELECTRON MICROSCOPY; UROGENITAL RIDGE; WISTAR RAT; ANIMAL; BODY WEIGHT; CHEMISTRY; DRUG EFFECTS; ORAL DRUG ADMINISTRATION; ORGAN SIZE; PATHOLOGY; TOXICITY TESTING; ULTRASTRUCTURE;

ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; MALE; METAL NANOPARTICLES; MICROSCOPY, ELECTRON, TRANSMISSION; ORGAN SIZE; RATS, WISTAR; SERTOLI CELLS; SILVER; SPERMATOCYTES; SPERMATOGONIA; TESTIS; TOXICITY TESTS, CHRONIC;

EID: 84988650904     PISSN: None     EISSN: 14773155     Source Type: Journal    
DOI: 10.1186/s12951-014-0042-8     Document Type: Article

References (33)

1. Johnston HJ, Hutchison G, Christensen FM, Peters, Hankin S, Stone V: A review of the in vivo and in vitro toxicity of and gold particulates, particle attributes and biological mechanisms responsible for the observed toxicity. Crit Rev Toxicol 2010, 40:328-346.
2. Chen X, Schluesener H: Nano a nanoproduct in medical application. Toxicol Lett 2008, 176:1-12.
3. Kalishwaralal K, Barathmanikanth S, Pandian SR, Deepak V, Gurunathan S: Nano A trove for retinal therapies. J Control Release 2010, 145:76-90.
4. Kumar A, Vemula PK, Ajayan PM, John G: Nanoparticle embedded antimicrobial paints based on vegetable oil. Nat Mater 2008, 7:236-241.
5. Sung JH, Ji JH, Yoon JU, Kim DS, Song MY, Jeong J: Lung function changes in Sprague Dawley rats after prolonged inhalation exposure to nanoparticles. Inhal Toxicol 2008, 20:567-574.
6. Ema M, Kobayashi N, Naya M, Hanai S, Nakanishi J: Reproductive and developmental toxicity studies of manufactured nanomaterials. Reprod Toxicol 2010, 30:343-352.
7. Kim YS, Song MY, Park JD, Song KS, Ryu HR, Chung YH: Sub chronic oral toxicity of nanoparticles. Part Fibre Toxicol 2010, 7:20-23.
8. Gromadzka OJ, Dziendzikowska K, Lankoff A: Nanoparticles effects on epididymal sperm in rats. Toxic Lett 2012, 8:214-251.
9. Dziendzikowska K, Gromadzka OJ, Lankoff A, Oczkowski M, Krawczynska A, Chwastowska: Time-dependent biodistribution and excretion of nanoparticles in male wistar rats. J Appl Toxicol 2012, 32:920-928.
10. Park EJ, Yi J, Kim Y, Choi K, Park K: Nanoparticles induce cytotoxicity by a Trojan horse type mechanism. Toxicol In Vitro 2010, 24:872-878.
11. Turkevich J, Stevenson PC, Hillier J: A study of the nucleation and growth processes in the synthesis of colloidal gold. Discuss Faraday Soc 1951, 11:55-75.
12. Gurr E: Staining Animal Tissues: Practical and Theoretical. London: Leonard Hill; 1962. 1:99.
13. Hubbs AF, Mercer RR, Benkovic SA, Harkema J, Sriram K, Schwegler BD, Goravanahally MP, Nurkiewicz TR, Castranova V, Sargent LM: Nanotoxicology a pathologist's perspective. Toxicol Pathol 2011, 39:301-324.
14. Chithrani BD, Ghazani AA, Chan WC: Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. NanoLett 2006, 6:662-668.
15. Stobiecka M, Hepel M: Double shell gold nanoparticles based DNA carriers with poly-l-lysine binding surface. Biomaterials 2011, 32:3312-3321.
16. Ahamed M, Karns M, Goodson M, Rowe J, Hussain SM, Schlager JJ, Hong Y: DNA damage response to different surface chemistry of nanoparticles in mammalian cells. Toxicol Appl Pharmacol 2008, 233:404-410.
17. Kim YS, Kim JS, Cho HS, Rha DS, Kim JM, Park JD, Choi BS, Lim R, Chang HK, Chung YH: Twenty eight day oral toxicity, genotoxicity and gender related tissue distribution of nanoparticles in sprague dawley rats. InhalationToxicol 2008, 20:575-583.
18. Loeschner K, Hadrup N, Qvortrup K, Larsen A, Gao X, Vogel U, Mortensen A, Lam HR, Larsen EH: Distribution of in rats following 28 days of repeated oral exposure to nanoparticles or acetate. Part FibreToxicol 2011, 8:18.
19. Park EJ, Bae E, Yi J, Kim Y, Choi K, Lee SH, Yoon J, Lee BC, Park K: Repeated dose toxicity and inflammatory responses in mice by oral administration of nanoparticles. Environ Toxicol Pharmacol 2010, 30:162-168.
20. Lankveld DP, Oomen AG, Krystek P, Neigh A, TroostdeJong A, Noorlander CW, VanEijkeren JC, Geertsma RE, DeJong WH: The kinetics of the tissue distribution of nanoparticles of different sizes. Biomaterials 2010, 31:8350-8361.
21. Park K, Park EJ, Chun IK, Choi K, Lee SH, Yoon J, Lee BC: Bioavailability and toxicokinetics of citrate coated nanoparticles in rats. Arch Pharmacol Res 2011, 34:153-158.
22. Tang J, Xiong L, Wang S, Wang J, Liu L, Li J, Yuan F, Xi T: Distribution translocation and accumulation of nanoparticles in rats. J Nanosci Nanotechnol 2009, 9:4924-4932.
23. Takenaka S, Karg E, Roth C, Schulz H, Ziesenis A, Heinzmann U, Schramel P, Heyder J: Pulmonary and systemic distribution of inhaled ultrafine particles in rats. Environ Health Perspect 2001, 109:547-551.
24. Dhermendra K, Takashi J, Behari J: Dose-dependent in-vivo toxicity assessment of nanoparticle in Wistar rats. Toxicol Mech Methods 2011, 21(1):13-24.
25. Lucian H, Marius S, Laura U, Anca N, Marius M, Liliana T, Viorel M: Exposure to nanoparticles induces oxidative stress and memory deficits in laboratory rats. Cent Eur J Biol 2011, 6(4):497-509.
26. Vasyl S, Ivan R, Yuryj S, Galyna M, Ivan H, Iryna M: Effects of nanoparticles in solution and liposomal form on some blood parameters in female rabbits during fertilization and early embryonic development. Microbial Biotech Food Sci 2014, 3(4):274-278.
27. Xue Y, Zhang S, Huang Y, Zhang T, Liu X, Hu Y, Zhang Z, Tang M: Acute toxic effects and gender related biokinetics of nanoparticles following an intravenous injection in mice. J Appl Toxicol 2012, jat:2742.
28. Lee JH, Kim YS, Song KS, Ryu HR, Sung JH, Park JD, Park HM, Song NW, Shin BS, Marshak D, Ahn K, Lee JE, Yu IJ: Bio persistence of nanoparticles in tissues from Sprague-Dawley rats. Part Fibre Toxicol 2013, 10:36.
29. Fairoze KI: Histological and ultra structural studies on the testis of rat after treatment with aluminum chloride. Aust J Basic Appl Sci 2007, 1(1):63-72.
30. Daryosh M, Abedelahi A, Soleimani J, Mohammadi A, Rashtbar M, Azami A: Degenerative effect of cisplatin on testicular germinal epithelium. Adv Pharmaceut Bull 2012, 2(2):173-177.
31. Mesbah S, Shokri S, Doust S, Mirkhani H: Effects of nandrolone decanoate on the ultrastructure of testis in adult male rats. IJMS 2008, 32(2):94-100.
32. Xiao L, Xiao YC, Zhi CW, Tong S, Huna Z: Effects of exposure to bisphenol A during pregnancy and lactation on the testicular morphology and caspase-3 protein expression of ICR pups. Biomed Rep 2013, 1(3):420-424.
33. Gozde ES, Yasemin EC, Cenk U, Emel DE, Feriha E: Distribution of Zonula Occludens-1 and Occludin and alterations of testicular morphology after in utero radiation and postnatal hyperthermia in rats. Int J Exp Pathol 2012, 93(6):438-449.