Development of antibody functionalized magnetic nanoparticles for the immunoassay of carcinoembryonic antigen: A feasibility study for clinical use

Journal of Nanobiotechnology

Volumn 12, Issue 1, 2014, Pages

  Yang, Che Chuan ^a   Yang, Shieh Yueh ^a   Ho, Chia Shin ^a   Chang, Jui Feng ^a   Liu, Bing Hsien ^a   Huang, Kai Wen ^b,c  

^a MAGQU CO LTD   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Assay; Bio magnetic nanoparticles; Carcinoembryonic antigen; Colorectal cancer

Indexed keywords

ANTIBODIES; ANTIGENS; ASSAYS; BIOASSAY; BODY FLUIDS; DISEASES; MOLECULES; NANOMAGNETICS; PARTICLE SIZE; SUSPENSIONS (FLUIDS); SYNTHESIS (CHEMICAL);

CARCINOEMBRYONIC ANTIGEN; COLORECTAL CANCER; COMMON MATERIALS; FEASIBILITY STUDIES; LOW DETECTION LIMIT; MAGNETIC NANO-PARTICLES; NORMAL CONTROLS; PARTICLE SUSPENSIONS;

NANOPARTICLES;

ANTIBODY; CARCINOEMBRYONIC ANTIGEN; MAGNETIC NANOPARTICLE; NANOCOATING; NANOMATERIAL; MAGNETITE NANOPARTICLE; TUMOR MARKER;

ARTICLE; BIOLOGICAL ACTIVITY; BIOMAGNETISM; CANCER PATIENT; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; FEASIBILITY STUDY; HUMAN; IMMUNOASSAY; LIMIT OF DETECTION; LIQUID; MOLECULAR DYNAMICS; MOLECULAR STABILITY; PARTICLE SIZE; SENSITIVITY AND SPECIFICITY; SIGNAL DETECTION; SUSPENSION; SYNTHESIS; BLOOD; CASE CONTROL STUDY; CHEMISTRY; COLORECTAL TUMOR; IMMUNOLOGY; PROCEDURES; TEMPERATURE;

ANTIBODIES; BIOMARKERS, TUMOR; CARCINOEMBRYONIC ANTIGEN; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; HUMANS; IMMUNOASSAY; LIMIT OF DETECTION; MAGNETITE NANOPARTICLES; PARTICLE SIZE; TEMPERATURE;

EID: 84988603131     PISSN: None     EISSN: 14773155     Source Type: Journal    
DOI: 10.1186/s12951-014-0044-6     Document Type: Article

References (28)

1. Hultman T, Ståhl S, Homes E, Uhlén M: Direct solid phase sequencing of genomic and plasmid DNA using magnetic beads as solid support. Nucleic Acids Res 1989, 17:4937-4946.
2. Kondo A, Kamura H, Higashitani K: Development and application of thermo-sensitive magnetic immunomicrospheres for antibody purification. Appl Microbiol Biotechnol 1994, 41:99-105.
3. Franzreb M, Siemann-Herzberg M, Hobley TJ, Thomas ORT: Protein purification using magnetic adsorbent particles. Appl Microbiol Biotechnol 2006, 70:505-516.
4. Gånshirt-Ahlert D, Börjesson-Stoll R, Burschyk M, Garritsen HSP, Helmer E, Miny P, Velasco M, Walde C, Patterson D, Teng N, Bhat NM, Bieber MM, Holzgreve W: Detection of fetal trisomies 21 and 18 from maternal blood using triple gradient and magnetic cell sorting. Am J Reprod Immunol 1993, 30:194-201.
5. Pamme N, Wilhelm C: Continuous sorting of magnetic cells via on-chip free-flow magnetophoresis. Lab Chip 2006, 6:974-980.
6. Adamsa JD, Kim U, Soh HT: Multitarget magnetic activated cell sorter. Proc Natl Acad Sci U S A 2008, 105:18165-18170.
7. Kim DK, Zhang Y, Kehr J, Klason T, Bjelke B, Muhammed M: Characterization and MRI study of surfactant-coated superparamagnetic nanoparticles administered into the rat brain. J Magn Magn Mater 2001, 225:256-261.
8. Huang KW, Chieh JJ, Lin IT, Horng HE, Yang HC, Hong CY: Anti-CEAfunctionalized superparamagnetic iron oxide nanoparticles for examining colorectal tumors in vivo. Nanoscale Res Lett 2013, 8:413-416.
9. Dobson J: Magnetic nanoparticles for drug delivery. Drug Dev Res 2006, 67:55-60.
10. Hergt R, Dutz S, Müller R, Zeisberger M: Magnetic particle hyperthermia: nanoparticle magnetism and materials development for cancer therapy. J Phys Condens Matter 2006, 18:S2919-S2934.
11. Kotitz R, Matz H, Trahms L, Koch H, Weitschies W, Rheinlander T, Semmler W, Bunte T: SQUID based remanence measurements for immunoassays. IEEE Trans Appl Supercond 1997, 7:3678-3681.
12. Enpuku K, Minotani T, Gima T, Kuroki Y, Itoh Y, Yamashita M, Katakura Y, Kuhara S: Detection of magnetic nanoparticles with superconducting quantum interference device (SQUID) magnetometer and application to immunoassays. Jpn J Appl Phys 1999, 38:L1102-L1105.
13. Hong CY, Wu CC, Chiu YC, Yang SY, Horng HE, Yang HC: Magnetic susceptibility reduction method for magnetically labeled immunoassay. Appl Phys Lett 2006, 88:1-3. 212512.
14. Baselt DR, Lee GU, Natesan M, Metzger SW, Sheehan PE, Colton RJ: A biosensor based on magnetoresistance technology. Biosens Bioelectron 1998, 13:731-739.
15. Krause HJ, Wolters N, Zhang Y, Offenhäusser A, Miethe P, Meyer MHF: Magnetic particle detection by frequency mixing for immunoassay applications. J Magn Magn Mater 2007, 311:436-444.
16. Horng HE, Yang SY, Huang YW, Jiang WQ, Hong CY, Yang HC: Nanomagnetic particles for SQUID-based magnetically labeled immunoassay. IEEE Trans Appl Supercond 2005, 15:668-671.
17. Liao SH, Yang HC, Horng HE, Chieh JJ, Chen KL, Chen HH, Chen JY, Liu CI, Liu CW, Wang LM: Time-dependent phase lag of biofunctionalized magnetic nanoparticles conjugated with biotargets studied with alternating current magnetic susceptometor for liquid phase immunoassays. Appl Phys Lett 2013, 103:1-3. 243703.
18. Shao H, Yoon TJ, Liong M, Weissleder R, Lee H: Magnetic nanoparticles for biomedical NMR-based diagnostics. Beilstein J Nanotechnol 2010, 1:142-154.
19. MagnaBioSciences, LLC. http://www.magnabiosciences.com/
20. Magnisense Co., Ltd. http://www.magnisense.com/
21. Lifeassays. http://www.lifeassays.com/
22. Xi'an Goldmag Nanobiotech Co., Ltd. http://www.goldmag.com.cn/
23. MagQu Co., Ltd. http://www.magqu.com/
24. Yang SY, Wang WC, Lan CB, Chen CH, Chieh JJ, Horng HE, Hong CH, Yang HC, Tsai CP, Yang CY, Cheng IC, Chung WC: Magnetically enhanced highspecificity virus detection using bio-activated magnetic nanoparticles with antibodies as labeling markers. J Virol Methods 2010, 164:14-18.
25. Jiang WQ, Yang HC, Yang SY, Horng HE, Hung JC, Chen YC, Hong CY: Preparation and properties of superparamagnetic nanoparticles with narrow size distribution and biocompatible. J Magn Magn Mater 2004, 283:210-214.
26. Chieh JJ, Yang SY, Horng HE, Yu CY, Lee CL, Wu HL, Hong CY, Yang HC: Immunomagnetic reduction assay using high-Tc superconductingquantum-interference-device-based magnetosusceptometry. J Appl Phys 2010, 107:1-5. 074903.
27. Yang CC, Yang SY, Chen HH, Weng WL, Horng HE, Chieh JJ, Hong CY, Yang HC: Effect of molecule-particle binding on the reduction in the mixed-frequency ac magnetic susceptibility of magnetic bio-reagents. J Appl Phys 2012, 112:1-4. 24704.
28. Yang SY, Chieh JJ, Huang KW, Yang CC, Chen TC, Ho CS, Chang SF, Chen HH, Horng HE, Hong CY, Yang HC: Molecule-assisted nanoparticle clustering effect in immunomagnetic reduction assay. J Appl Phys Lett 2013, 113:1-5. 144903.